- The advantages of acupuncture anesthesia in clinical practice
In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.
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Body System Protection
- Brain Protection
- Acupuncture anesthesia plays a vital role in brain surgeries, ensuring precise and safe anesthesia, reducing the risk of neurological complications, and supporting optimal cognitive function.
- Lung Protection
- Acupuncture anesthesia reduces post-operative lung complications, aiding in rapid lung function recovery, particularly beneficial for lung surgeries.
- Neuroprotection
- Acupuncture anesthesia is crucial for safeguarding the nervous system, reducing nerve injuries, and preventing the progression of neurological disorders.
- Kidney
- Acupuncture anesthesia alleviates stress on the kidneys, reducing the risk of kidney injury, particularly valuable in kidney surgeries.
- Gastrointestinal Tract
- Acupuncture anesthesia supports gastrointestinal health, reducing the risk of post-operative digestive issues, and ensuring a smoother recovery.
- Cardiovascular
- Acupuncture anesthesia eases the cardiovascular system's burden, reducing the risk of cardiovascular complications, especially in cardiac surgeries.
- Myocardium
- Acupuncture anesthesia aids in protecting the myocardium, minimizing adverse effects on heart muscle, ensuring cardiac health.
- Cognitive Function
- Through emotional stability and neuroprotection, acupuncture anesthesia helps preserve cognitive function, reducing the risk of post-operative cognitive impairment.
- Motor Function
- Acupuncture anesthesia improves motor function, aiding in post-operative mobility, and enhancing overall quality of life.
- Language Function
- Acupuncture anesthesia supports language function rehabilitation, assisting patients in regaining their communication skills.
- Learning and Memory Ability
- Acupuncture anesthesia, by reducing post-operative pain and emotional instability, enhances learning and memory ability, promoting a speedy recovery.
Acupuncture anesthesia for Body System Protection-Learning and Memory Ability
| PMID | Evidence | Source | Keyword | Type |
|---|---|---|---|---|
| 24566146 | Recent studies suggest that both manual acupuncture and EA can significantly improve learning memory in immobilization or chronic injection of corticosterone (CORT) rat stress models. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Learning and Memory Ability | Review |
| 24566146 | This indicates that acupuncture can ameliorate learning memory deficits via direct activation of the neurotrophin signaling pathways, significantly reversing CORT or stress induced reduction of BDNF and CREB expression in the hippocampus. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Learning and Memory Ability | Review |
| 24566146 | Altogether, these studies suggest that acupuncture can initiate pCREB-BDNF transcription, and modulate adaptive neuronal responses required for learning and memory functions. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Learning and Memory Ability | Review |
| 25097658 | These observations indicate that acupuncture-induced antioxidative effect may be related to GSH system and antioxidant enzyme in hippocampus which is crucial to learning and memory formation in vascular dementia patients and models. | Evid Based Complement Alternat Med. 2014;2014:483294. doi: 10.1155/2014/483294. Epub 2014 Jul 7. | Learning and Memory Ability | Review |
| 25097658 | These observations suggest that the effects of acupuncture on learning-memory capacity in AD rats/patients may be related to neuronal mitochondrial integration, Aβ plaques, and acetylcholine neurotransmission. | Evid Based Complement Alternat Med. 2014;2014:483294. doi: 10.1155/2014/483294. Epub 2014 Jul 7. | Learning and Memory Ability | Review |
| 27543143 | A systematic review and meta-analysis of acupuncture for improving learning and memory ability in animals | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | Acupuncture has been widely used in China and the effectiveness for improving learning and memory has been mentioned in previous studies. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | We conducted this systematic review and meta-analysis to evaluate the effectiveness of acupuncture for improving learning and memory in animal experiments. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | These findings show acupuncture has a potential role in improving learning and memory ability in animal models, suggesting it as a candidate therapy for memory loss of aged brain. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | More and more studies have been published to confirm the effectiveness of acupuncture for improving learning and memory. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | Up to now, there have been no systematic reviews to analyze the effectiveness of acupuncture for improving learning and memory. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | Additionally, animal experiment can make us better understand the mechanism of acupuncture on learning and memory and guide the future clinical study. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | Therefore, we conducted a systematic review and meta-analysis of the effectiveness of acupuncture for improving learning and memory in animal experiments to provide suggestions for future animal experiments and clinical trials. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | Search terms consisted of two groups: intervention (acupuncture and other related terms) and object (learning and memory and other related terms). | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | Several different signaling pathways were investigated to gain a better understanding of the underlying mechanism of acupuncture in the amelioration of learning and memory impairment. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | To our knowledge, this is the first systematic review and meta-analysis to explore the efficacy of acupuncture for improving learning and memory in animal experiments with the results of Morris water maze test as the outcome measures. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | This systematic review and meta-analysis indicated that acupuncture could reduce time of escape latency, decrease frequency of cross platform and increase the time in target quadrant in animal model of learning and memory impairment. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | It suggests that acupuncture has a potential role in improving learning and memory impairment in animal models. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | The most common acupoints in acupuncture treatment for improving learning and memory were GV20 (baihui), ST36 (zusanli), GV14 (dazhui), BL23 (shenshu), BL17 (geshu) and CV17 (danzhong). | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | The mechanism of acupuncture on improving learning and memory ability remains unclear. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | Therefore, the effectiveness of acupuncture for improving learning and memory may be overstated. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 27543143 | In animal model, acupuncture has a potential role in improving learning and memory ability. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Learning and Memory Ability | Review |
| 28664077 | Acupuncture stimulation at the PC6 point is effective in restoring chronic mild stress-induced behavioral impairments, such as impaired learning and memory, in the Morris water maze test, and increased acetylcholinesterase reactivity in the hippocampus. | Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. | Learning and Memory Ability | Review |
| 31379957 | Acupuncture improved the spatial learning and memory ability of AD mice by increasing blood perfusion and glucose uptake in the bilateral amygdala, hippocampus, and left temporal lobe. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Learning and Memory Ability | Review |
| 31467579 | The results showed that electroacupuncture can reduce the expression of p-tau protein in the hippocampus of rats with Alzheimer's disease by regulating the p38MAPK pathway and can improve learning and memory ability. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Learning and Memory Ability | Review |
| 32337259 | To perform a systematic review to identify the effect of verum-acupuncture compared with sham-acupuncture on learning and memory performance among animal models of AD. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Learning and Memory Ability | Review |
| 32630156 | Acupuncture also counteracts p38 MAPK signal transduction, reduces Aβ deposits in the brain, and improves learning and memory in AD patients. | Int J Mol Sci. 2020 Jun 30;21(13):4693. doi: 10.3390/ijms21134693. | Learning and Memory Ability | Review |
| 33408601 | reported that acupuncture alone or acupuncture combined with donepezil treatment reduced cortical Aβ amyloid content and improved spatial learning and memory in SAMP8 mice. | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Learning and Memory Ability | Review |
| 33408601 | Several studies have reported that acupuncture ameliorated hippocampal neuroinflammation via downregulation of the NLRP3 inflammasome and decreased production of downstream pro-inflammatory cytokines like IL-1β and Caspase-1 (Jiang et al.,; Ding et al.,), thus improving learning and memory abilities in SAMP8 mice. | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Learning and Memory Ability | Review |
| 33408601 | showed that acupuncture at the GV24 and GB13 acupoints improved learning and memory abilities in Aβ1â42-induced AD rats, possibly by increasing glycolysis metabolism in the thalamus, hypothalamus, and brain stem areas. | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Learning and Memory Ability | Review |
| 33505460 | Some studies showed that both manual acupuncture (MA) and electroacupuncture (EA) could ameliorate the learning and memory deficits of AD mice models through inducing the enhancement of neuron proliferation and migration in hippocampal DG and VZ/SVZ. | Neural Plast. 2021 Jan 12;2021:8868447. doi: 10.1155/2021/8868447. eCollection 2021. | Learning and Memory Ability | Review |
| 33505460 | It was demonstrated that acupuncture was able to promote synapse-structure damage rehabilitation by upregulating the expression of SYN, PSD-95, and GAP-43 to improve the learning and memory abilities of AD and VCI murine models. | Neural Plast. 2021 Jan 12;2021:8868447. doi: 10.1155/2021/8868447. eCollection 2021. | Learning and Memory Ability | Review |
| 33917977 | In behavioral evaluation, acupuncture, including manual acupuncture and electro-acupuncture, reduced anxiety and fear responses and weakened fear conditioning, improved sleep architecture, reduced depressive symptoms, and alleviated disturbance of spatial learning and memory of PTSD animal models. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Learning and Memory Ability Anxiety | Review |
| 33917977 | In these studies, the effects and/or underlying mechanisms of acupuncture on anxiety and fear behaviors, depression behavior, sleep disturbance, cognitive symptoms (especially spatial learning and memory), and stress responses in PTSD animal models have been reported (Figure 3 and Table 2). | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Insomnia Stress Response Learning and Memory Ability Anxiety Depression | Review |
| 33917977 | In behavioral evaluation, acupuncture, including MA and EA, reduced anxiety and fear responses and weakened fear conditioning, improved sleep architecture, reduced depressive symptoms, and alleviated the disturbance of spatial learning and memory in PTSD animal models. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Learning and Memory Ability Anxiety | Review |
| 33917977 | In behavioral evaluation, acupuncture, including MA and EA, reduced anxiety and fear responses and weakened fear conditioning, improved sleep architecture, reduced depressive symptoms, and alleviated the disturbance of spatial learning and memory of the PTSD animal models. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Learning and Memory Ability Anxiety | Review |
| 36211826 | proved that acupuncture could upregulate the expression of sirtuin3 (SIRT30) and GATA factor 2, improve mitochondrial function, regulate energy metabolism, and improve the learning and memory function of SAMP8 mice. | Oxid Med Cell Longev. 2022 Sep 28;2022:6080282. doi: 10.1155/2022/6080282. eCollection 2022. | Learning and Memory Ability | Review |
| 36211826 | observed that acupuncture in SAMP8 mice can increase the expression of SIRT3 and peroxisome proliferator-activated receptor gamma coactivator-1α in the hippocampus, improve mitochondrial energy metabolism, and thereby improve learning and memory. | Oxid Med Cell Longev. 2022 Sep 28;2022:6080282. doi: 10.1155/2022/6080282. eCollection 2022. | Learning and Memory Ability | Review |
| 36211826 | Acupuncture can also affect synaptic plasticity through other mechanisms such as miRNA, gut flora, and neural circuits, thereby improving learning and memory. | Oxid Med Cell Longev. 2022 Sep 28;2022:6080282. doi: 10.1155/2022/6080282. eCollection 2022. | Learning and Memory Ability | Review |
| 36408345 | Third, the formation of the reward effect of acupuncture analgesia itself is a type of conditional learning process that involves the coding, consolidation, and reconsolidation of learning and memory. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Learning and Memory Ability | Review |
| 36670425 | Acupuncture at GV24 and GB13 can enhance the learning and memory of AD model rats, and the mechanism may be related to the modulation of the activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE). | Chin Med. 2023 Jan 20;18(1):8. doi: 10.1186/s13020-023-00707-x. | Learning and Memory Ability | Review |
| 36741282 | Manual acupuncture (MA) at Taixi (KI3) and Taichong (LR3) can promote functional recovery as well as learning and memory abilities after ischemic stroke by enhancing BDNF and SYN expression and synaptic structural reconstruction in the ipsilateral hippocampus after I/R. | Front Neurol. 2023 Jan 20;14:1082625. doi: 10.3389/fneur.2023.1082625. eCollection 2023. | Learning and Memory Ability | Review |
| 36925735 | The study has found that electroacupuncture (EA) stimulation at GV20, GV14, and BL23 can improve the learning and memory ability of VD rats, reduce the ultrastructural damage of hippocampal CA1 neurons, and repair damaged neurons. | Front Neurosci. 2023 Feb 28;17:1118508. doi: 10.3389/fnins.2023.1118508. eCollection 2023. | Learning and Memory Ability | Review |
| 37091130 | Meanwhile, animal experiments also found evidence of improved learning and memory after cerebral infarction by acupuncture through the cAMP/PKA/CREB signaling pathway. | Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. | Learning and Memory Ability | Review |
| 37091130 | Acupuncture can impact learning and memory by enhancing acetylcholine levels in the brain, and it may have similar regulatory principles on the prognosis of PSA. | Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. | Learning and Memory Ability | Review |
| 37200784 | Moreover, animal studies have shown that acupuncture treatment can reduce anxiety, depression, and fear responses; improve sleep architecture; reduce spatial learning and memory deficits; and ultimately improve PTSD (Kwon et al.,). | Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. | Learning and Memory Ability Anxiety Depression | Review |
| 37360179 | Functional characterization showed that acupuncture at ST36 was mainly associated with motor, cognition, learning and memory, self-awareness, and other aspects (Figure 3C). | Front Neurosci. 2023 Jun 9;17:1180434. doi: 10.3389/fnins.2023.1180434. eCollection 2023. | Learning and Memory Ability | Review |
| 37360179 | Therefore, based on the functional characteristics of acupuncture at ST36, we found that this may be effective in the treatment of motor, cognition, learning and memory, self-awareness, and other aspects. | Front Neurosci. 2023 Jun 9;17:1180434. doi: 10.3389/fnins.2023.1180434. eCollection 2023. | Learning and Memory Ability | Review |
| 37360179 | This study found that acupuncture at ST36 activated the bilateral cerebellum, hemispheric lobule VIII, bilateral Rolandic operculum, and right supramarginal gyrus, suggesting that acupuncture at ST36 could be used to treat motor, cognitive, learning and memory, and emotion-related disorders. | Front Neurosci. 2023 Jun 9;17:1180434. doi: 10.3389/fnins.2023.1180434. eCollection 2023. | Learning and Memory Ability Mood | Review |
| 37363406 | The above studies suggested that acupuncture may reduce the inflammatory infiltration and apoptosis of the hippocampus and hypothalamus, improve its cell morphology and tissue structure, thus improve fatigue, learning and memory ability, and cognitive dysfunction of CFS rats. | World J Acupunct Moxibustion. 2023 Mar 17. doi: 10.1016/j.wjam.2023.03.002. | Cognitive Function Learning and Memory Ability | Review |
| 37363406 | It was suggested that acupuncture may improve the learning and memory ability of CFS model rats by regulating free radical metabolism. | World J Acupunct Moxibustion. 2023 Mar 17. doi: 10.1016/j.wjam.2023.03.002. | Learning and Memory Ability | Review |
| 37397457 | Numerous basic studies have shown that acupuncture improves secondary cognitive impairments, such as PSCI, mainly using the measure of improved learning memory in animal models. | Front Neurosci. 2023 Jun 15;17:1211044. doi: 10.3389/fnins.2023.1211044. eCollection 2023. | Learning and Memory Ability | Review |
| 37397457 | Acupuncture at ST36 and GV20 can promote the release of dopamine and its main metabolites (DA, epinephrine, HVA, D1R and D5R) in the hippocampus of rats, improved LTP impairment at the perforant pathway (PP)-dentate gyrus (DG) synapse, and significantly attenuated 2VO-induced learning and memory deficits. | Front Neurosci. 2023 Jun 15;17:1211044. doi: 10.3389/fnins.2023.1211044. eCollection 2023. | Learning and Memory Ability | Review |
| 37397457 | Acupuncture at GV20, Qianding (GV21), Xinhui (GV22) and GV24 can also upregulate the release of neurotransmitters such as acetylcholine (ACh), DA, and 5-hydroxytryptamine (5-HT) in hippocampus, improving the learning and memory functions of 2VO rats. | Front Neurosci. 2023 Jun 15;17:1211044. doi: 10.3389/fnins.2023.1211044. eCollection 2023. | Learning and Memory Ability | Review |
| 37546517 | Ge et al established a diabetic model of adult SD rats by using streptozotocin (STZ) have shown that electroacupuncture promotes mitophagy and improves the learning and memory function of rats by increasing the expression of Disrupted-in-Schizophrenia 1 (DISC1). | Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. | Learning and Memory Ability | Review |
| 37614343 | The treatment of sleep-deprived rats with acupuncture affected their learning and memory. | Front Neurosci. 2023 Aug 8;17:1243029. doi: 10.3389/fnins.2023.1243029. eCollection 2023. | Learning and Memory Ability | Review |
| 37780709 | Acupuncture at Bai hui (GV20) and Si shencong (Ex-HN1) significantly enhanced growth and development, improved neurobehavioral functions, learning and memory abilities. | Front Neurol. 2023 Sep 14;14:1248348. doi: 10.3389/fneur.2023.1248348. eCollection 2023. | Learning and Memory Ability | Review |
| 31736488 | Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze. | J Vis Exp. 2019 Oct 29;(152). doi: 10.3791/60055. | Learning and Memory Ability | Mechanism |
| 31736488 | It is widely used in scientific research to assess the learning and memory of animals. | J Vis Exp. 2019 Oct 29;(152). doi: 10.3791/60055. | Learning and Memory Ability | Mechanism |
| 31736488 | To assess the learning and memory ability of AD model mice, the MWM test was conducted. | J Vis Exp. 2019 Oct 29;(152). doi: 10.3791/60055. | Learning and Memory Ability | Mechanism |
| 31736488 | The visible platform trial, hidden platform trial, probe trial, and reversal trial of MWM were used to evaluate spatial learning and memory ability. | J Vis Exp. 2019 Oct 29;(152). doi: 10.3791/60055. | Learning and Memory Ability | Mechanism |
| 31736488 | The results of the MWM tests suggest that MA can effectively improve the spatial learning and memory abilities of AD model mice. | J Vis Exp. 2019 Oct 29;(152). doi: 10.3791/60055. | Learning and Memory Ability | Mechanism |
| 26116163 | Behavioral functions, learning and memory ability, and body weight were observed at different time-points after HI. | J Ethnopharmacol. 2015 Aug 22;172:124-32. doi: 10.1016/j.jep.2015.06.032. Epub 2015 Jun 23. | Learning and Memory Ability | Mechanism |
| 26116163 | RESULTS: The results showed that acupuncture significantly promoted growth and development, improved neurobehavioral function, learning and memory ability after 20 days' treatment. | J Ethnopharmacol. 2015 Aug 22;172:124-32. doi: 10.1016/j.jep.2015.06.032. Epub 2015 Jun 23. | Learning and Memory Ability | Mechanism |
| 19733189 | Acupuncture with the manipulation of the needles according to traditional Chinese medicine or with the electrical stimulation applied on needles inserted into the acupoints (referred as electro-acupuncture, EA) may modulate stress response, mood, learning and memory process. | Physiol Behav. 2009 Dec 7;98(5):537-42. doi: 10.1016/j.physbeh.2009.08.011. Epub 2009 Sep 3. | Stress Response Learning and Memory Ability Mood | Mechanism |
| 30843424 | RESULTS: We found that, compared with the untreated SAMP8 group, donepezil, manual acupuncture, and combined therapy with donepezil and manual acupuncture all improved spatial learning and memory ability, the level of glucose metabolism in the brain, and the content of Abeta amyloid in the cortex. | Acupunct Med. 2019 Feb;37(1):64-71. doi: 10.1136/acupmed-2016-011310. Epub 2019 Mar 7. | Learning and Memory Ability | Mechanism |
| 23499955 | Grading score of senescence and Morris water maze results showed that SAMP8 presented aging-related deterioration of learning and memory, and that acupuncture could improve the learning and memory ability of SAMP8. | Neurosci Lett. 2013 May 10;542:59-64. doi: 10.1016/j.neulet.2013.03.002. Epub 2013 Mar 14. | Learning and Memory Ability | Mechanism |
| 23499955 | These findings suggested that the learning and memory deterioration of SAMP8 with aging might be associated with the lower TPI activity and that acupuncture could improve the cognitive impairment by increasing TPI activity, thus correcting the abnormal glycolysis metabolism and maintaining the brain homeostasis and internal environment. | Neurosci Lett. 2013 May 10;542:59-64. doi: 10.1016/j.neulet.2013.03.002. Epub 2013 Mar 14. | Learning and Memory Ability | Mechanism |
| 18215464 | Senescence-accelerated mouse prone 8 (SAMP8) is an autogenic senile strain characterized by early cognitive impairment and age-related deterioration of learning and memory. | Neurosci Lett. 2008 Feb 20;432(2):111-6. doi: 10.1016/j.neulet.2007.12.009. Epub 2007 Dec 15. | Learning and Memory Ability | Mechanism |
| 23525450 | Additionally, electroacupuncture improved learning and memory ability in cerebral I/R injured rats, demonstrating its therapeutic efficacy against post-stroke cognitive impairment. | Mol Med Rep. 2013 May;7(5):1516-22. doi: 10.3892/mmr.2013.1392. Epub 2013 Mar 22. | Learning and Memory Ability | Mechanism |
| 26276454 | Behavioral tests including rotarod, open-field, learning and memory, and social behavior tests were performed during PND 14-PND 40. | J Acupunct Meridian Stud. 2015 Aug;8(4):183-91. doi: 10.1016/j.jams.2015.06.008. Epub 2015 Jun 19. | Learning and Memory Ability | Mechanism |
| 30552029 | Moreover, learning and memory significantly improved in EA-treated rats compared with MCAO or MCAO + CA rats (P < .05) together with an increase in the number of PSD-95(+) and SYN(+) cells and synapses in the hippocampal CA1 region (P < .05). | J Stroke Cerebrovasc Dis. 2019 Mar;28(3):792-799. doi: 10.1016/j.jstrokecerebrovasdis.2018.11.025. Epub 2018 Dec 12. | Learning and Memory Ability | Mechanism |
| 37992796 | After intervention, the spatial learning and memory of the mice was assessed using the Morris water maze test. | Brain Res. 2024 Jan 15;1823:148683. doi: 10.1016/j.brainres.2023.148683. Epub 2023 Nov 20. | Learning and Memory Ability | Mechanism |
| 30726543 | A Y-maze was used to test cognitive function (learning and memory). | J Mol Neurosci. 2019 Mar;67(3):456-466. doi: 10.1007/s12031-018-1253-5. Epub 2019 Feb 6. | Cognitive Function Learning and Memory Ability | Mechanism |
| 28450287 | Morris water maze tests were used to investigate learning and memory abilities. | Acupunct Med. 2017 Aug;35(4):289-296. doi: 10.1136/acupmed-2016-011139. Epub 2017 Apr 27. | Learning and Memory Ability | Mechanism |
| 28478802 | Electroacupuncture ameliorates spatial learning and memory impairment via attenuating NOX2-related oxidative stress in a rat model of Alzheimer's disease induced by Abeta1-42. | Cell Mol Biol (Noisy-le-grand). 2017 Apr 29;63(4):38-45. doi: 10.14715/cmb/2017.63.4.7. | Learning and Memory Ability | Mechanism |
| 28478802 | The present study aimed to determine the effects of EA treatment on spatial learning and memory impairment, and to elucidate the status of NOX2-related oxidative stress in a rat model of Alzheimer's disease induced by Beta-amyloid1-42 (Abeta1-42). | Cell Mol Biol (Noisy-le-grand). 2017 Apr 29;63(4):38-45. doi: 10.14715/cmb/2017.63.4.7. | Learning and Memory Ability | Mechanism |
| 28478802 | The spatial learning and memory functions were assessed by Morris water maze (MWM) test. | Cell Mol Biol (Noisy-le-grand). 2017 Apr 29;63(4):38-45. doi: 10.14715/cmb/2017.63.4.7. | Learning and Memory Ability | Mechanism |
| 28478802 | The results showed that EA treatment significantly improved spatial learning and memory impairment in rats induced by Abeta1-42. | Cell Mol Biol (Noisy-le-grand). 2017 Apr 29;63(4):38-45. doi: 10.14715/cmb/2017.63.4.7. | Learning and Memory Ability | Mechanism |
| 26895770 | RESULTS: In the MWM test, the AD+EA group showed an improvement in parameters consistent with improved learning/memory compared to untreated AD rats, and 3-MA attenuated these effects. | Acupunct Med. 2016 Dec;34(6):449-456. doi: 10.1136/acupmed-2015-010894. Epub 2016 Feb 19. | Learning and Memory Ability | Mechanism |
| 26895770 | CONCLUSIONS: EA reduces neuronal apoptosis, enhances degradation of Abeta, and improves learning/memory in AD rats by upregulating the autophagy pathway. | Acupunct Med. 2016 Dec;34(6):449-456. doi: 10.1136/acupmed-2015-010894. Epub 2016 Feb 19. | Learning and Memory Ability | Mechanism |
| 37723951 | Acupuncture could improve the spatial learning and memory ability of SAMP8 mice, and partially prevent the reduction in the number of spines on the secondary branches of the apical dendrites in the hippocampus and the attenuation of LTP. | Curr Alzheimer Res. 2023;20(6):420-430. doi: 10.2174/1567205020666230828095826. | Learning and Memory Ability | Mechanism |
| 37723951 | CONCLUSION: Acupuncture can improve synaptic plasticity by inhibiting the abnormal activation of the RhoA/ROCK pathway, and improve the spatial learning and memory ability of AD, so as to achieve the purpose of treating AD. | Curr Alzheimer Res. 2023;20(6):420-430. doi: 10.2174/1567205020666230828095826. | Learning and Memory Ability | Mechanism |
| 38126262 | RESULTS: Significant amelioration of neurological deficits and learning/memory were found in MCAO + GB20 rats compared with MCAO or MCAO + NA rats. | Acupunct Med. 2024 Feb;42(1):23-31. doi: 10.1177/09645284231202805. Epub 2023 Oct 15. | Learning and Memory Ability | Mechanism |
| 37548586 | Further, alterations in brain structure can bring about mania, mental depression, sleep disorders, learning and memory impairment, and personality deficits. | Brain Behav. 2023 Oct;13(10):e3177. doi: 10.1002/brb3.3177. Epub 2023 Aug 7. | Learning and Memory Ability Depression | Mechanism |
| 32761882 | Acupuncture stimulation resulted in a significant improvement in the spatial learning and memory deficit and reversed neuronal damage in the hippocampus. | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Learning and Memory Ability | Mechanism |
| 32761882 | This study demonstrated that needle retention, treatment frequency, and needle manipulation are important factors in improving the learning and memory as well as reducing the neuronal damage of the hippocampus in a rat VD model. | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Learning and Memory Ability | Mechanism |
| 32761882 | The first day after acupuncture treatment, the MWM was performed to detect changes in spatial learning and memory performance in the different groups of rats as previous described (Du et al., 2018). | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Learning and Memory Ability | Mechanism |
| 32761882 | To assess whether needle retention improves learning and memory impairment in VD rats, direction, and escape latency, the time spending in the target quadrant and swimming speed were measured in a MWM experiment. | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Learning and Memory Ability | Mechanism |
| 32761882 | Acupuncture with manipulation was more effective in the learning and memory impairment in VD rats | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Learning and Memory Ability | Mechanism |
| 33645011 | Spatial learning and memory ability estimated by the Morris water maze | J Cell Mol Med. 2021 Apr;25(8):3816-3828. doi: 10.1111/jcmm.16295. Epub 2021 Mar 1. | Learning and Memory Ability | Mechanism |
| 33645011 | In addition, we investigated spatial learning and memory ability using the Morris water maze. | J Cell Mol Med. 2021 Apr;25(8):3816-3828. doi: 10.1111/jcmm.16295. Epub 2021 Mar 1. | Learning and Memory Ability | Mechanism |
| 33645011 | In this test, we observed that rats in the acupoint catgut embedding group had shorter escape latency times from day 3 of training onward compared with rats in the model group, indicating that acupoint catgut embedding may improve spatial learning and memory ability in ageing rats (Figure 1C). | J Cell Mol Med. 2021 Apr;25(8):3816-3828. doi: 10.1111/jcmm.16295. Epub 2021 Mar 1. | Learning and Memory Ability | Mechanism |
| 33645011 | These results indicate that the inhibition of autophagy reduced the memory improvement effect of acupoint catgut embedding treatment, suggesting that autophagy has at least some effect on learning and memory impairment during ageing. | J Cell Mol Med. 2021 Apr;25(8):3816-3828. doi: 10.1111/jcmm.16295. Epub 2021 Mar 1. | Learning and Memory Ability | Mechanism |
| 33645011 | After observing that acupoint catgut embedding in rats delayed the signs of ageing in the hair, diet, spontaneous activity, mental state, motor coordination, and learning and memory ability, we further investigated whether acupoint catgut embedding also plays a role in ageing in the hippocampus, which is the brain area related to spatial learning and memory. | J Cell Mol Med. 2021 Apr;25(8):3816-3828. doi: 10.1111/jcmm.16295. Epub 2021 Mar 1. | Learning and Memory Ability | Mechanism |
| 34659396 | The results showed that EA could promote the survival of the grafted MGE neural progenitors differentiated from hESCs and alleviate learning and memory impairment in rats with cerebral ischemia. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | A study found that in the absence of NKX2.1 (the main marker of MGE), cholinergic septohippocampal projection neurons and large subsets of basal forebrain cholinergic neurons fail to develop, causing severe deficiencies in learning and memory. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | MGE neural progenitors can be used as a cell source to treat learning and memory impairment. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | Morris water maze (MWM) task was used to evaluate hippocampus-dependent spatial learning and memory. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | MGE Neural Progenitor Transplantation Alleviated Learning and Memory Impairment in 2VO Rats and EA Enhanced Transplantation Therapy's Efficacy | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | The above results of the MWM task indicated that MGE neural progenitor transplantation alleviated learning and memory impairment in 2VO rats, and EA enhanced transplantation therapy's efficacy. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | A study found that in the absence of NKX2.1, cholinergic septohippocampal projection neurons and large subsets of basal forebrain cholinergic neurons fail to develop, causing alterations in the hippocampal theta rhythms and severe deficiencies in learning and memory. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | MGE neural progenitors are mainly differentiated into GABAergic neurons and cholinergic neurons in vitro, used as a cell source to treat learning and memory impairment. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | In the MWM task, compared with the rats in the 2VO group, the rats in the 2VO+Cell group showed a reduction in the escape latency and increased time spent in the target quadrant, indicating that learning and memory impairment in 2VO rats was alleviated. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | Considering that more HuNu+-positive cells were observed in the 2VO+Cell+EA group in cellular quantification analysis, we speculated that EA facilitated the cell grafting effect on learning and memory impairment by promoting the grafted cells' survival in the hippocampus. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | In summary, our study demonstrated that EA could promote the survival of the grafted MGE neural progenitors differentiated from human embryonic pluripotent stem cells and alleviated learning and memory impairment in rats with cerebral ischemia, which partially resulted from inhibited inflammation response and increased angiogenesis. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34659396 | Comparison of the effects on spatial learning and memory test in rats from different groups. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 25342636 | Diabetes significantly decreases the learning and memory functions and promotes cognitive impairment and vascular dementia in humans. | J Vet Med Sci. 2015 Feb;77(2):167-73. doi: 10.1292/jvms.14-0400. Epub 2014 Oct 22. | Learning and Memory Ability | Mechanism |
| 36003380 | Furthermore, EA stimulation at DU20 and KI1 ameliorated learning and memory deficits and enhanced synaptic plasticity via activation of the PKA/CREB signaling pathway. | Front Immunol. 2022 Aug 8;13:955581. doi: 10.3389/fimmu.2022.955581. eCollection 2022. | Learning and Memory Ability | Mechanism |
| 36003380 | Another study indicated that EA stimulation at KI1 significantly prevented spatial learning and memory impairment in rodents via the mediation of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase2 (NOX2) in hippocampus. | Front Immunol. 2022 Aug 8;13:955581. doi: 10.3389/fimmu.2022.955581. eCollection 2022. | Learning and Memory Ability | Mechanism |
| 33384922 | In particular, the Sigma1 receptor (Sigma1 R) has been shown to play a role in learning and memory, responses to stress and depression, psychostimulant-induced sensitization, and vulnerability to addiction. | Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. | Learning and Memory Ability Depression | Mechanism |
| 36816326 | Acupuncture treatment was sufficient to reduce the frequency and numbers of Th17Â cells in these animals while increasing Treg cell levels, thereby alleviating cognitive deficits with respect to both spatial learning and memory impairment. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Learning and Memory Ability | Mechanism |
| 36816326 | As such, in the present study we sought to explore whether modulating the Th17/Treg balance via acupuncture would be sufficient to improve spatial learning and memory in VD model rats in an effort to better define the therapeutic effects of acupuncture on both immunological function and cognitive impairment. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Immunity Cognitive Function Learning and Memory Ability | Mechanism |
| 36816326 | Acupuncture treated of VD model rats alleviates spatial learning and memory deficits | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Learning and Memory Ability | Mechanism |
| 36816326 | Acupuncture improved the spatial learning and memory ability of VD mice in the Morris water mazeï¼aï¼Escape latency values of each group in the hidden platform trial.ï¼bï¼Escape latency of each group in the reversal platform trial. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Learning and Memory Ability | Mechanism |
| 36816326 | Together, these results thus suggested that acupuncture can effectively attenuate spatial learning and memory deficits of VD rats. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Learning and Memory Ability | Mechanism |
| 36816326 | In this study, we found acupuncture to reverse VD-related changes in the Th17/Treg balance in VD rats while simultaneously improving their disease-related spatial learning, memory, and cognition defects. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Learning and Memory Ability | Mechanism |
| 34630618 | The effect of the treatment was measured by the Morris water maze test for learning and memory ability and magnetic resonance spectroscopy (MRS) for neuronal metabolism in the hippocampus of rats with hepatic encephalopathy. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34630618 | EA can also improve the metabolism of NAA and Cho in the rat hippocampus and thereby improve learning and memory abilities. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34630618 | Studies have shown that CHE is independently associated with death in patients with cirrhosis, and the onset of HE in such patients may lead to persistent and cumulative cognitive impairments, including brain dysfunction affecting learning, memory, attention, executive function, and reasoning. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34630618 | The hippocampus is an important functional region of the nervous system that is closely related to learning and memory. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34630618 | Finally, at the end of the 12th week of intervention, the rats' learning and memory function was measured by using the Morris water maze. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34630618 | The Morris water maze test was used to measure the learning and memory ability of rats in each group before and after modeling and after treatment with EA. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34630618 | Morris water maze is a classic method to observe the spatial learning and memory abilities in experimental rodent models, in which animals are trained to navigate to a platform located below the water's surface for the spatial cognition test. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34630618 | The above results showed that EA improved the learning and memory disorders caused by HE. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34630618 | The results suggest that EA combined with other treatments may be able to modulate the metabolism of NAA, Glx, and Cho in the hippocampus in rats with HE and thereby improve the learning and memory performance in Morris water maze. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 34630618 | We used Morris water maze to investigate the spatial learning and memory of rats with HE-related cognitive impairment. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Learning and Memory Ability | Mechanism |
| 27978835 | MEK1 is crucial in hippocampal-dependent learning, memory, and synaptic plasticity. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Learning and Memory Ability | Mechanism |
| 30136700 | The Morris water maze test was conducted to assess the learning and memory. | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Learning and Memory Ability | Mechanism |
| 30136700 | As the key regulator in Wnt signaling, changes in GSK-3β activity are associated with synaptic plasticity, which has been established as a cellular model for learning and memory (Liang and Chuang, 2007). | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Learning and Memory Ability | Mechanism |
| 30136700 | Effects of EA on learning and memory in AD rats | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Learning and Memory Ability | Mechanism |
| 30136700 | Figure 1 shows the results from the Morris water-maze tests, reflecting spatial learning and memory in the various groups of rats. | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Learning and Memory Ability | Mechanism |
| 30136700 | The escape latencies were significantly shorter in the 50-Hz EA and 30-Hz EA groups than in the 2-Hz EA group (P < 0.05), suggesting better learning and memory ability. | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Learning and Memory Ability | Mechanism |
| 30136700 | Effects of EA treatment on spatial learning and memory in a rat model of Alzheimer's disease (Morris water maze test). | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Learning and Memory Ability | Mechanism |
| 30136700 | Synapse ultrastructure, such as synaptic curvatures, the width of the synaptic cleft, and the thickness of the postsynaptic density provide a structural basis for learning and memory abilities (Ziff, 1997; Boeckers, 2006; Bourne and Harris, 2008). | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Learning and Memory Ability | Mechanism |
| 30136700 | Additionally, compared with the model group, spatial learning and memory performance significantly increased along with rescued hippocampal synaptic structure in the EA-treated groups, which is consistent with Shao et al. | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Learning and Memory Ability | Mechanism |
| 30136700 | In conclusion, EA treatment greatly improved spatial learning and memory and rescued hippocampal synaptic structure in a mouse model of AD. | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Learning and Memory Ability | Mechanism |
| 31836020 | In AD mice, a loss of synapses is observed and leads to learning and memory impairments. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Learning and Memory Ability | Mechanism |
| 31836020 | Acupuncture improves spatial learning and memory and prevents changes in dendritic structures in the SAMP8 model. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Learning and Memory Ability | Mechanism |
| 31836020 | In AD patients and the corresponding animal models, Aβ deposition is detected in both the hippocampus and the cerebral cortex, resulting in learning and memory impairments. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Learning and Memory Ability | Mechanism |
| 37066940 | Acupuncture improves learning and memory ability of posttraumatic stress disorder model rats through epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Learning and Memory Ability | Mechanism |
| 37066940 | The study goal is to gain a better understanding of the mechanism by which EA affects synapses provides insights into how electroacupuncture (EA) modulates synaptic plasticity in learning and memory. | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Learning and Memory Ability | Mechanism |
| 37066940 | The mechanism of EA improving the learning and memory ability of PTSD rats may be that it can promote the competitive combination of WWP2 and PTEN by inhibiting Linc RNA02023, and then lead to microglial PI3K and its pathway activation, BDNF up-regulation, and finally induce LTP and repair damaged synaptic plasticity. | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Learning and Memory Ability | Mechanism |
| 37066940 | These findings suggest that microglia play an active role in synaptic plasticity, which is the molecular biological basis of learning and memory. | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Learning and Memory Ability | Mechanism |
| 37066940 | In addition, impaired microglia-mediated remodelling of neuronal circuits could severely impair learning and memory. | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Learning and Memory Ability | Mechanism |
| 37066940 | Our previous studies confirmed that PTSD model rats showed significant emotional disturbances, such as anxiety, depression, and fear, as well as obvious declines in learning and memory. | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Learning and Memory Ability Anxiety Depression Mood | Mechanism |
| 37066940 | One of the core PTSD symptom is the persistence of memories of the traumatic event that triggered PTSD (i.e., traumatic fear memory) . Recent studies have confirmed that acupuncture can suppress or eliminate fear memory as well as improve sleep architecture, relieve depression, and alleviate spatial learning and memory deficits ; moreover, acupuncture has relatively long-term effects and few side effects. | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Side Effects Learning and Memory Ability Depression | Mechanism |
| 37066940 | Synaptic plasticity is the neurobiological basis of learning and memory, and the PI3K-AKT pathway regulates BDNF to participate in the induction and maintenance of LTP in hippocampal CA1 region, thus contributing to synaptic plasticity. | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Learning and Memory Ability | Mechanism |
| 37066940 | Microglia promote synaptic formation through BDNF signal transduction to play the role of learning and memory . | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Learning and Memory Ability | Mechanism |
| 37066940 | PTEN-mediated dysregulation of the PI3K-AKT signalling pathway is an important mechanism underlying the decline in learning and memory. | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Learning and Memory Ability | Mechanism |
| 28852400 | Learning and memory abilities were tested using the Y-maze test system (Zhenhua Teaching Instrument Factory, Yuanyang, China). | Neural Regen Res. 2017 Jul;12(7):1159-1165. doi: 10.4103/1673-5374.211197. | Learning and Memory Ability | Mechanism |
| 28852400 | Effects of long-term acupuncture at ST36 on learning and memory abilities in AD rats | Neural Regen Res. 2017 Jul;12(7):1159-1165. doi: 10.4103/1673-5374.211197. | Learning and Memory Ability | Mechanism |
| 28852400 | After acupuncture, the ST36 and sham-point groups displayed a significant improvement in learning and memory functions, evidenced by the reduction in the length of time required for training to achieve the learning criterion in the Y-maze test (Figure 1). | Neural Regen Res. 2017 Jul;12(7):1159-1165. doi: 10.4103/1673-5374.211197. | Learning and Memory Ability | Mechanism |
| 28852400 | Learning and memory skills assessed by Y-maze test. | Neural Regen Res. 2017 Jul;12(7):1159-1165. doi: 10.4103/1673-5374.211197. | Learning and Memory Ability | Mechanism |
| 25206746 | The hippocampus is a brain region closely associated with learning and memory abilities and emotion. | Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. | Learning and Memory Ability Mood | Mechanism |
| 25206746 | It is selectively affected by the high levels of glucocorticoids in stress, resulting in decreased hippocampal synaptic plasticity, and neuronal atrophy and loss, which consequently influences learning and memory abilities. | Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. | Learning and Memory Ability | Mechanism |
| 25206591 | In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect Neuropathic Pain Learning and Memory Ability | Mechanism |
| 25206591 | A model of OVX-induced learning-memory impairment was established before CCI. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Learning and Memory Ability | Mechanism |
| 25206591 | Results indicated that the OVX rats had a defect in learning and memory (results not shown). | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Learning and Memory Ability | Mechanism |
| 32082125 | Chronic exhaustive exercise significantly reduced the body weight and exhaustive swimming time, and induced impairment in learning and memory, and which were reversed by WA treatment. | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 32082125 | These findings demonstrated that WA could alleviate the chronic exhaustive swimming-induced fatigue and improve the learning and memory ability, and the actions might be related to the reduction of inflammatory response and iNOS expression. | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 32082125 | The exhaustive exercise stress could induce neuroinflammatory response in the hippocampus and cause brain damage, which impairs learning and memory (Schwarz et al.,; Morgan et al.,). | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 32082125 | For example, NO in the hippocampus participates in the learning and memory process as a neurotransmitter (Mosher et al.,; Andrade Próspero et al.,; Berenyiova et al.,). | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 32082125 | The Morris water maze was used to measure spatial learning and memory abilities (Vouros et al.,). | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 32082125 | The results showed that chronic exhaustive exercise significantly reduced the body weight and exhaustive swimming time, and induced the impairment in learning and memory, which were reversed by WA treatment. | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 32082125 | These findings demonstrated that WA could alleviate the chronic exhaustive swimming-induced fatigue and improve the learning and memory ability, and the effect may be achieved by downregulating the iNOS level and reducing the expressions of proinflammatory cytokines. | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 32082125 | Our results showed that chronic exhaustive exercise reduced the body weight and exhaustive swimming time, and induced impairment in learning and memory, which were reversed by WA treatment. | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 32082125 | These findings demonstrated that WA could alleviate the chronic exhaustive swimming-induced fatigue and improve the learning and memory ability by reducing inflammatory response and iNOS expression in the brain. | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 33328963 | Novel object recognition task and Morris water maze were performed to evaluate short-term memory and spatial learning and memory. | Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. | Learning and Memory Ability | Mechanism |
| 33328963 | Acupuncture Ameliorates Short-term and Spatial and Learning Memory of BCCAO-Induced CCH Rats. | Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. | Learning and Memory Ability | Mechanism |
| 33328963 | In this study, our results demonstrate that spatial learning and memory of BCCAO rats could be ameliorated by acupuncture treatment, as evidenced by increased white matter perfusion and integrity. | Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. | Learning and Memory Ability | Mechanism |
| 33328963 | Large number of studies suggest that spatial learning and memory are impaired in BCCAO rats. | Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. | Learning and Memory Ability | Mechanism |
| 33328963 | In summary, the present study reveals that acupuncture protects short-term memory and spatial and learning memory of BCCAO rats through increasing subcortical white matter perfusion and improving white matter integrity. | Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. | Learning and Memory Ability | Mechanism |
| 37096024 | Behavioral tests showed that acupuncture treatment improved spontaneous activity, aberrant social interaction, and alleviated impaired learning and memory in the VPA-induced rat model. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Learning and Memory Ability | Mechanism |
| 37096024 | Hippocampus plays an important role in the limbic system, which is involved in physiological processes such as the formation and regulation of emotions and the formation of learning and memory. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Learning and Memory Ability Mood | Mechanism |
| 37096024 | For example, acupuncture may improve cognitive impairment by promoting the release of dopamine and its main metabolites in the hippocampus of AD rats, and may improve learning and memory ability by changing the levels of NAA and Cho in the hippocampus of ischemia reperfusion rats, or improve the learning and memory ability of autistic rats by regulating the expression of PSD-95 protein in the hippocampus. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Learning and Memory Ability | Mechanism |
| 37096024 | Serotonin, an important neurotransmitter and endogenous active substance, is critically involved in brain development and innervates the entire central nervous system, which allows serotonin to affect diverse physiological processes, including the sleep-wake cycle, learning and memory, mood, and aggression. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Learning and Memory Ability Mood | Mechanism |
| 37096024 | Acupuncture Alleviated Impaired Learning and Memory in VPA Rat Model | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Learning and Memory Ability | Mechanism |
| 37096024 | Rats were trained and tested in the MWM to assess differences in learning and memory among different groups of rats (Table 2). | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Learning and Memory Ability | Mechanism |
| 37096024 | In Morris water maze experiment, with the increase in the number of training days, all of the rats could find the target quadrant faster than before, and the degree of improvement of the WT and VPA_acupuncture groups were significantly better than the VPA group, which suggested that the learning and memory of VPA group rats were damaged, and acupuncture treatment could significantly improve this problem. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Learning and Memory Ability | Mechanism |
| 37096024 | After acupuncture, the rats in the target quadrant were more active, also indicating that their learning and memory were improved. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Learning and Memory Ability | Mechanism |
| 33269744 | Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Learning and Memory Ability | Mechanism |
| 33269744 | Electroacupuncture stimulation applied to the Shenting (GV24) and Baihui (GV20) acupoints activated the PI3K/Akt signaling pathway and improved rat learning and memory impairment. | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Learning and Memory Ability | Mechanism |
| 33269744 | Cognitive impairment and decline in patients with stroke during the acute and chronic phases, particularly the impairment of learning and memory, has a very high clinical incidence. | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Learning and Memory Ability | Mechanism |
| 33269744 | The aim of the present study was to investigate whether EA applied to the Baihui (GV20) and Shenting (GV24) acupoints improved learning and memory impairment following middle cerebral artery occlusion (MCAO) in rats via the PI3K/Akt signaling pathway. | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Learning and Memory Ability | Mechanism |
| 33269744 | To evaluate learning and memory abilities, the rats were tested using the Morris water maze, as previously described (Feng et al., 2013; He et al., 2018; Wen et al., 2018), starting at the 4th day after surgery. | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Learning and Memory Ability | Mechanism |
| 33269744 | EA reduces the learning and memory impairments observed in rats with focal cerebral ischemia/reperfusion injury | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Learning and Memory Ability | Mechanism |
| 33269744 | These results indicate that EA treatment significantly improved the learning and memory abilities of the MCAO rats. | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Learning and Memory Ability | Mechanism |
| 33269744 | Numerous studies have demonstrated that EA can significantly improve learning and memory impairments (Tao et al., 2010; Luo et al., 2013). | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Learning and Memory Ability | Mechanism |
| 33269744 | Therefore, this pathway may represent a major target for the treatment of learning and memory impairments. | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Learning and Memory Ability | Mechanism |
| 29623942 | Sanjiao acupuncture and HuangDiSan can promote the proliferation, migration and differentiation of exogenous neural stem cells in senescence-accelerated mouse prone 8 (SAMP8) mice and can improve learning and memory impairment and behavioral function in dementia-model mice. | Neural Regen Res. 2018 Mar;13(3):541-548. doi: 10.4103/1673-5374.228760. | Learning and Memory Ability | Mechanism |
| 29623942 | Sanjiao acupuncture improved learning and memory impairment, as well as behavior in dementia-model mice, and has a positive effect on NSC migration and expression of differentiation-related proteins and genes (Cheng et al., 2008). | Neural Regen Res. 2018 Mar;13(3):541-548. doi: 10.4103/1673-5374.228760. | Learning and Memory Ability | Mechanism |
| 29623942 | Among the SAM mice, SAMP8 mice show deficits in learning and memory abilities (Takeda et al., 1981). | Neural Regen Res. 2018 Mar;13(3):541-548. doi: 10.4103/1673-5374.228760. | Learning and Memory Ability | Mechanism |
| 29623942 | To eliminate sensory, visual or motor dysfunction effects on spatial learning and memory abilities, a 1-day visual platform trial was used. | Neural Regen Res. 2018 Mar;13(3):541-548. doi: 10.4103/1673-5374.228760. | Learning and Memory Ability Motor Function | Mechanism |
| 29623942 | Morris water maze visible platform trials indicated that differences in sensory, visual or motor functions did not significantly affect spatial learning or memory. | Neural Regen Res. 2018 Mar;13(3):541-548. doi: 10.4103/1673-5374.228760. | Learning and Memory Ability Motor Function | Mechanism |
| 29623942 | SAMP8 mice had cognitive impairment in learning and memory acquisition, lower memory retention and re-learning ability. | Neural Regen Res. 2018 Mar;13(3):541-548. doi: 10.4103/1673-5374.228760. | Learning and Memory Ability | Mechanism |
| 29623942 | Hippocampal transplantation of NSCs significantly improved learning and memory dysfunction, memory retention, and re-learning ability of SAMP8 mice. | Neural Regen Res. 2018 Mar;13(3):541-548. doi: 10.4103/1673-5374.228760. | Learning and Memory Ability | Mechanism |
| 29623942 | As shown above, learning and memory, memory retention, and relearning abilities in SAMP8 mice were improved, and synaptophysin levels in the hippocampus were significantly increased after transplantation of NSCs. | Neural Regen Res. 2018 Mar;13(3):541-548. doi: 10.4103/1673-5374.228760. | Learning and Memory Ability | Mechanism |
| 30127121 | Effectiveness of acupuncture is documented after stroke in limb disorders (Zhao et al., 2015; Lou et al., 2016; Shi et al., 2017), dysphagia (Zhang et al., 2016), shoulder pain (Chau et al., 2018), and shoulder-hand syndrome (Zheng et al., 2018), as well as recovery of learning and memory deficits (Liu et al., 2017b). | Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. | Learning and Memory Ability | Mechanism |
| 26654890 | After scanning, the Y-maze test of spatial learning and memory was also repeated and the final TRT of each group was recorded. | Acupunct Med. 2016 Jun;34(3):215-22. doi: 10.1136/acupmed-2015-010865. Epub 2015 Dec 9. | Learning and Memory Ability | Mechanism |
| 35722406 | In this study, we investigated the effect of EA at the Baihui (GV 20) and Shenting (GV 24) acupoints on spatial learning and memory ability, and the expression level of microRNA-81 (miR-81), interleukin-16 (IL-16), and postsynaptic density protein-95 (PSD-95) in the frontal cortex of VaD rats. | Ann Transl Med. 2022 May;10(10):540. doi: 10.21037/atm-22-2068. | Learning and Memory Ability | Mechanism |
| 35722406 | In VaD rats, EA may improve spatial learning and memory through miR-81/IL-16/PSD-95 pathway. | Ann Transl Med. 2022 May;10(10):540. doi: 10.21037/atm-22-2068. | Learning and Memory Ability | Mechanism |
| 35722406 | Multiple studies have reported that acupuncture affects microRNA (miRNA) expression in the brains of animal models for hypoxia/ischemia, effectively improves learning and memory, and reduces neuronal apoptosis. | Ann Transl Med. 2022 May;10(10):540. doi: 10.21037/atm-22-2068. | Learning and Memory Ability | Mechanism |
| 35722406 | To assess spatial learning and memory, we performed the MWM test 24 hours after the final EA treatment (Guangzhou Feidi Biology Science and Technology Co., Ltd., Guangzhou, China). | Ann Transl Med. 2022 May;10(10):540. doi: 10.21037/atm-22-2068. | Learning and Memory Ability | Mechanism |
| 35722406 | It has also been shown that acupuncture can upregulate PSD-95 expression and promote the repair of synaptic structural damage, thereby improving learning and memory in the vascular cognitive impairment mouse model. | Ann Transl Med. 2022 May;10(10):540. doi: 10.21037/atm-22-2068. | Learning and Memory Ability | Mechanism |
| 35722406 | In this study, acupuncture stimulation of the Baihui and Shenting acupoints stimulated the production of miR-81 in the frontal cortex of rats with VaD, downregulated its target IL-16, and reduced neuronal apoptosis in the frontal cortex, thereby promoting the expression of the postsynaptic membrane scaffold protein PSD-95 and improved the learning and memory of rats with VaD, and these were proved in PC12 cells under OGD/R conditions. | Ann Transl Med. 2022 May;10(10):540. doi: 10.21037/atm-22-2068. | Learning and Memory Ability | Mechanism |
| 37383281 | The sleep status, learning and memory ability, body weight, mental state, response to external interference and other general behaviors were observed before and after treatment. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Learning and Memory Ability | Mechanism |
| 37383281 | The positioning navigation experiment was used to train the learning and memory ability of the rats. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Learning and Memory Ability | Mechanism |
| 37383281 | If the platform was not found within the specified time, the animal was actively placed on the platform for 15 s to induce learning and memory ability. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Learning and Memory Ability | Mechanism |
| 37383281 | These results indicated that acupuncture treatment improved the learning and memory ability of rats and promoted the recovery of learning and memory function. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Learning and Memory Ability | Mechanism |
| 37383281 | It plays an important role in the synaptic plasticity of neurons in brain regions, which mainly regulates learning and memory processes. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Learning and Memory Ability | Mechanism |
| 37383281 | In conclusion, the results show that acupuncture at the Back-Shu point can improve the cognitive behavior changes and emotional disorders caused by insomnia, improve learning and memory ability in rats, and promote learning and memory function recovery. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia Learning and Memory Ability Mood | Mechanism |
| 37383281 | Studies have shown that U0126 can effectively inhibit the proliferation, migration and apoptosis of cancer cells in vivo, and antioxidant protection of neuronal cells; thus, it is widely used in the treatment of nerve damage, sleep disorders, decreased learning and memory ability, and cancer caused by hypoxia and ischemia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Learning and Memory Ability | Mechanism |
| 37383281 | In summary, acupuncture at Back-Shu point can promote appetite, prolong sleep time, improve learning and memory ability, maintain the balance of proinflammatory cytokine secretion, and improve rats' mental state, activity, and excessive behavior. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Learning and Memory Ability | Mechanism |
| 35251208 | Our results in the MWM test were consistent with findings in previous studies, indicating that SPS-exposed rats develop learning and memory deficits during the acquisition phase. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Learning and Memory Ability | Mechanism |
| 35251208 | However, acupuncture focused on the HT7 acupoint restored the ability to maintain spatial learning and memory formation; it shortened the escape latencies while increasing the time and distance in the target quadrant. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Learning and Memory Ability | Mechanism |
| 35251208 | These results are more dependent on the mPFC and Hipp than the Amg concerning the recovery of learning and memory; we presume that neuroinflammatory changes in the mPFC and Hipp contribute to pathological recovery after fear memory abnormalities. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Learning and Memory Ability | Mechanism |
| 35251208 | Moreover, the mPFC and Hipp, which respond effectively to acupuncture focused on the HT7 acupoint, are brain regions related to learning and memory. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Learning and Memory Ability | Mechanism |
| 28860844 | Spatial learning and memory abilities were determined in the Morris water maze. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Learning and Memory Ability | Mechanism |
| 28860844 | Our previous study revealed that chronic trigeminal neuralgia in rats induced by cobra venom impairs spatial learning and memory function as assessed by the Morris water maze test. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia Learning and Memory Ability | Mechanism |
| 28860844 | However, since the underlying mechanism is unclear, there is a lack of effective therapeutic strategies to improve deficits in spatial learning and memory. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Learning and Memory Ability | Mechanism |
| 28860844 | The Morris water maze task was conducted to evaluate the spatial learning and memory ability of rats after either EA or pregabalin treatment. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Learning and Memory Ability | Mechanism |
| 28860844 | The Morris water maze test was used to measure spatial learning and memory at 1 week before the operation and 1, 3 and 5 weeks after the operation, respectively. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Learning and Memory Ability | Mechanism |
| 28860844 | In the pregabalin group, the escape latency increased by 25.3% at 3 weeks after the operation and by 37.5% at 5 weeks after the operation compared to the sham-operated group (week 3: #P=0.048, week 5: #P=0.033; Figure 3C, D), with no difference in spatial learning or memory when compared to the cobra venom group (P>0.05; Figure 3C, D). | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Learning and Memory Ability | Mechanism |
| 28860844 | Wu et al revealed that chronic trigeminal neuralgia induced by cobra venom in rats impairs spatial learning and memory function in the Morris water maze test. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia Learning and Memory Ability | Mechanism |
| 28860844 | LTP is an activity-dependent, long-lasting increase in the efficacy of synaptic transmission, and it is widely considered one of the major cellular mechanisms that underlie learning and memory. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Learning and Memory Ability | Mechanism |
| 28860844 | These findings indicated that trigeminal neuralgia induced by cobra venom in rats could lead to deficits in areas of the brain associated with the abilities of spatial learning and memory. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia Learning and Memory Ability | Mechanism |
| 28860844 | Although pregabalin demonstrated a dramatic behavioral analgesic effect on chronic trigeminal pain in this study, it did not suppress the development of deficits in the abilities of spatial learning and memory. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Analgesic Effect Learning and Memory Ability | Mechanism |
| 28860844 | In brief, these data indicate that EA stimulation not only decreased neuropathic pain behavior induced by cobra venom, but also improved deficits in spatial learning and memory abilities induced by chronic trigeminal neuralgia. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain Neuralgia Learning and Memory Ability | Mechanism |
| 25767501 | The experimental findings indicate that electroacupuncture improves learning and memory ability by up-regulating expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of vascular dementia rats. | Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009. | Learning and Memory Ability | Mechanism |
| 25767501 | Furthermore, electroacupuncture improves learning and memory of VD rats by limiting the formation of free radicals. | Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009. | Learning and Memory Ability | Mechanism |
| 25767501 | Learning and memory abilities of VD rats by electroacupuncture | Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009. | Learning and Memory Ability | Mechanism |
| 25767501 | The navigation test in the Morris water maze test was used to evaluate learning and memory ability of the rats. | Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009. | Learning and Memory Ability | Mechanism |
| 25767501 | Learning and memory ability of rats analyzed by navigation test | Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009. | Learning and Memory Ability | Mechanism |
| 29980225 | Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | The hippocampus plays an important role in cognitive function in the nervous system, and neurons in hippocampus are the main cells responsible for learning and memory. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Cognitive Function Learning and Memory Ability | Mechanism |
| 29980225 | The proliferation and differentiation of neurons have accompany with the process of learning and memory change. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | Glutamate (Glu) is the most important excitatory neurotransmitter in the central nervous system which could regulate synaptic transmission, neuronal growth and differentiation, synaptic plasticity and learning and memory. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family and it is the most neurotrophic factor in the body, which is tightly regulated by activity-dependent cellular processes and is strongly linked with mechanisms underlying learning and memory. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | The aim of the present study was to explore the mechanism of EA to improve learning and memory. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | In this study, learning and memory was evaluated in APP/PS1 transgenic mice by Morris water maze and step-down avoidance test, the material metabolism of the hippocampus were measured by MRS, the expression of BDNF and TrkB were detected by Western blot, and neuronal morphology were observed by Nissl staining. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | In order to evaluate learning and memory, Morris water maze test was performed for 5Â days as previously described. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | EA could ameliorate the learning and memory impairment in APP/PS1 transgenic mice | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | EA at Baihui (DU20) acupoint improve the learning and memory of APP/PS1 mice in Morris water maze task. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | These findings suggested that the learning and memory function was improved by EA at DU20 acupuncture in APP/PS1 double transgenic mice. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | EA at Baihui (DU20) acupoint improved the damaged learning and memory of APP/PS1 double transgenic mice. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | The results of step-down avoidance test were demonstrated that the damaged learning and memory was improved by EA at DU20 acupuncture in APP/PS1 double transgenic mice. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | In this present study, Morris water maze test and step-down avoidance test had been shown that the learning and memory were significantly injured in APP/PS1 transgenic mice. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | The results suggested that EA at DU20 acupuncture had specificity of improve the learning and memory impairment in APP/PS1 transgenic mice. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | At the same time, behavioral tests showed that mice had learning and memory disorders with material metabolic changes, and both of those were the result of neuronal absence. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | In the Nissl staining, the changes of neuronal cell number and structure in the APP/PS1+DU20 group reflect that EA at DU20 acupuncture has unique advantage to ameliorate the learning and memory impairment in APP/PS1 double transgenic mice. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | The activation of the BDNF-TrkB signal pathway is necessary for consolidate hippocampus-dependent learning and memory. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | In our study, the absence and structural damage of neuronal cells resulted in inhibition of BDNF-TrkB in the APP/PS1 group, appearing cognitive impairment which performance as learning and memory dysfunction. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Learning and Memory Ability | Mechanism |
| 29980225 | It might be the mechanism underlying EA improve learning and memory and it also provides the foundation for the clinical treatment and research of cognitive dysfunction in the future. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Cognitive Function Learning and Memory Ability | Mechanism |
| 25767502 | In addition, the cholinergic system plays an important role in learning and memory pathways. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Learning and Memory Ability | Mechanism |
| 25767502 | Our previous studies have demonstrated that protein kinase A and synaptophysin expression in hippocampal cells induces a repeated electroacupuncture (EA)-induced analgesic effect; when learning and memory ability are impaired by ovariotomy (OVX), the cumulative analgesic effect is decreased. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect Learning and Memory Ability | Mechanism |
| 25767502 | Models of OVX-induced learning-memory attenuation were generated in the CCI + OVX, CCI + OVX + EA 2D, and CCI + OVX + EA 2W groups before model establishment of chronic neuropathic pain. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Neuropathic Pain Learning and Memory Ability | Mechanism |
| 25767502 | In the central nervous system, ACh, which is a major excitatory neurotransmitter, exhibits a variety of effects on sensory perception, plasticity, learning and memory, and in particular on perception and pain control. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Learning and Memory Ability | Mechanism |
| 25767502 | These results suggested a reduced cumulative effect of EA in learning and memory attenuation. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Learning and Memory Ability | Mechanism |
| 25767502 | OVX-induced learning and memory attenuation is a result of significantly reduced estrogen (and progesterone) secretion from the ovary. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Learning and Memory Ability | Mechanism |
| 25767502 | In summary, hippocampal CA1 acetylcholine and the M1 muscarinic receptor are involved in the cumulative analgesic effect of repeated EA, which suggests a role for repeated EA in learning and memory. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect Learning and Memory Ability | Mechanism |
| 25767502 | Forty-five days after OVX, learning and memory was analyzed by escape latency in the Morris water maze for 7 days. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Learning and Memory Ability | Mechanism |
| 25767502 | The rats with learning and memory impairment were considered as successful models. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Learning and Memory Ability | Mechanism |
| 30106051 | Acupuncture improves dendritic structure and spatial learning and memory ability of Alzheimer's disease mice | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Learning and Memory Ability | Mechanism |
| 30106051 | After 14 days of treatment, spatial learning and memory ability of mice was assessed in each group using the Morris water maze. | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Learning and Memory Ability | Mechanism |
| 30106051 | These results suggest that acupuncture improves spatial learning and memory ability of middle-aged SAMP8 mice by ameliorating dendritic structure. | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Learning and Memory Ability | Mechanism |
| 30106051 | Spatial learning and memory ability of SAMP8 mice declines along with typical pathological hallmarks of AD including senile plaques, tau-like neurofibrillary tangles, and neuropathological changes (Cheng et al., 2014). | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Learning and Memory Ability | Mechanism |
| 30106051 | Acupuncture improved spatial learning and memory ability in SAMP8 mice | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Learning and Memory Ability | Mechanism |
| 30106051 | Acupuncture improved spatial learning and memory ability of SAMP8 mice in the Morris water maze. | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Learning and Memory Ability | Mechanism |
| 30106051 | In conclusion, dendrites are the therapeutic target of acupuncture for AD, and acupuncture may ameliorate dendritic structure and improve spatial learning and memory ability of middle-aged SAMP8 mice. | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Learning and Memory Ability | Mechanism |
| 30431067 | The MWM is a powerful tool for assessing spatial learning and memory in rats. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Learning and Memory Ability | Mechanism |
| 33229729 | PEA effectively improves spatial learning and memory in the rat model of D-gal-induced aging | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Learning and Memory Ability | Mechanism |
| 33229729 | As shown in Figure 1, rats given intraperitoneal injection of D-gal showed impaired learning and memory abilities, as evidenced by the increased escape latency to find the hidden platform in the navigation trial. | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Learning and Memory Ability | Mechanism |
| 33229729 | These results indicate that PEA and PMA treatments both rescue the learning and memory impairments in the rat model of D-gal-induced aging, and that PEA has a stronger protective effect. | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Learning and Memory Ability | Mechanism |
| 33229729 | PEA, PMA and PEA + inhibitor treatment ameliorated spatial learning and memory deficits in rats with D-galactose-induced aging, and PEA treatment was more effective than PMA or PEA + inhibitor treatment. | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Learning and Memory Ability | Mechanism |
| 33229729 | In the present study, we investigated the effects of PEA and PMA on tau phosphorylation and learning and memory functions in a D-gal-induced aging rat model, which is known to exhibit cognitive impairment and AD-like pathologies, including Aβ deposition (Tsai et al., 2011), tau hyperphosphorylation (Hong et al., 2016), neuroinflammation (Gao et al., 2016) and cholinergic deficits (Zhang et al., 2014). | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Learning and Memory Ability | Mechanism |
| 33229729 | In the current study, we found that chronic intraperitoneal injection of D-gal induced significant spatial learning and memory impairment, consistent with previous studies (Zhan et al., 2014; Fu et al., 2018). | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Learning and Memory Ability | Mechanism |
| 33229729 | Additionally, PEA plus inhibitor treatment improved learning and memory functions. | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Learning and Memory Ability | Mechanism |
| 25657670 | Furthermore, experimental studies have demonstrated that hippocampal synaptic plasticity is associated with learning, memory and adaptive processes, and is accompanied by changes in expression of a variety of genes and proteins. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Learning and Memory Ability | Mechanism |
| 25657670 | The OVX model of learning and memory impairment was applied in the CCI + OVX, CCI + OVX + electroacupuncture 2 days and the CCI + OVX + electroacupuncture 2 weeks groups before establishment of chronic neuropathic pain. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Neuropathic Pain Learning and Memory Ability | Mechanism |
| 31785199 | Glutamate acts on NMDA receptors to affect learning and memory, as they affect the survival of neurons, regulate the development of neuronal dendrites and axons, and participate in the formation of synaptic plasticity. | Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. | Learning and Memory Ability | Mechanism |
| 31045558 | As a common means of PTSD, acupuncture has high efficiency, long duration of action, and low side effects, it can effectively reduce anxiety-like behaviors and improve the impaired learning-memory ability in PTSD rats . | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Side Effects Learning and Memory Ability Anxiety | Mechanism |
| 31045558 | Acupuncture can improve clinical symptoms such as anxiety, panic and low learning and memory in patients with PTSD, and its efficacy is even better than that of paroxetine . | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability Anxiety | Mechanism |
| 31045558 | Synaptic plasticity is the carrier structure and molecular mechanism of learning and memory, and is the basis of learning and memory. | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability | Mechanism |
| 31045558 | Amygdala plays an important role in the formation, expression and regression of fear , its synapses are closely related to the function of learning and memory . | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability | Mechanism |
| 31045558 | In brain science research, LTP is considered to be a manifestation of synaptic plasticity, a functional basis for learning and memory, and an experimental model of synaptic plasticity. | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability | Mechanism |
| 31045558 | Hippocampus is recognized as a core brain region involved in the regulation of learning and memory, its synaptic plasticity is closely related to learning and memory . | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability | Mechanism |
| 31045558 | Assessment of spatial learning and memory functions using the test as reported previously . | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability | Mechanism |
| 31045558 | The above results indicate that electroacupuncture improves spatial learning and memory (Fig. 1). | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability | Mechanism |
| 31045558 | After the HFS stimulation, the average amplitude of the normal group (Ctrl) fEPSP was maintained (276.35 15.08) % at 30Â min, and at 60Â min and 90Â min, it still maintained at high levels, which are (204.33 10.90)% and (173.49 9.33)% separately.It indicated that LTP could be successfully induced under the experimental conditions.Compared with the Ctrl group, the fEPSP of the SPS and SPS&S groups were significantly suppressed at each time point, suggesting that the LTP in the hippocampus of the PTSD model was significantly inhibited, consistent with the decline in learning and memory ability. | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability | Mechanism |
| 31045558 | Compared with the SPS and SPS&S groups, the amplitude of fEPSP in the SPS+EA group and the SPS&S+EA group increased significantly at each time point, suggesting that the LTP in the electroacupuncture groups was significantly improved, which was consistent with the improvement of learning and memory ability (Fig. 7). | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability | Mechanism |
| 31045558 | The results above suggested that electroacupuncture treatment can improve the learning and memory ability of PTSD rats, which may be related to its up-regulation of LTP in hippocampus, maintenance of synaptic morphology (mainly up-regulation of PSD thickness, improvement of synaptic interface curvature) and up-regulation of BDNF levels in hippocampus and amygdala. | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability | Mechanism |
| 31045558 | According to the relevant data of the behavioral test, it can be known that the two modeling methods can obviously induce anxiety, depression and fear-like behaviors and can significantly reduce spatial learning and memory ability in rats. | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Learning and Memory Ability Anxiety Depression | Mechanism |
| 31045558 | As the most commonly used traditional treatment for neurological diseases, electroacupuncture is to give a suitable pulse current while acupoints treatment,it can improve the spatial learning and memory ability of patients with PTSD, and may have protective effects on hippocampal neurons . | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Heart Rate Learning and Memory Ability | Mechanism |
| 31871478 | CREB regulates the expression of gene-encoding proteins involved in regulating important brain functions, such as generation of neurons, learning, memory, metabolism, and neuroplasticity. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 33505601 | Morris water maze test was used to study the learning and memory ability of mice after NSC transplantation. | World J Stem Cells. 2020 Dec 26;12(12):1576-1590. doi: 10.4252/wjsc.v12.i12.1576. | Learning and Memory Ability | Mechanism |
| 33505601 | Morris water maze test showed significant cognitive impairment of learning and memory in 8-mo-old SAMP8, which improved in all the NSC transplantation groups. | World J Stem Cells. 2020 Dec 26;12(12):1576-1590. doi: 10.4252/wjsc.v12.i12.1576. | Learning and Memory Ability | Mechanism |
| 33505601 | Senescence-accelerated mouse prone 8 (SAMP8) mice have been used as an AD model of significantly low learning and memory ability. | World J Stem Cells. 2020 Dec 26;12(12):1576-1590. doi: 10.4252/wjsc.v12.i12.1576. | Learning and Memory Ability | Mechanism |
| 33505601 | Among them, SAMP8 mice show significant age-related deficits of learning and memory. | World J Stem Cells. 2020 Dec 26;12(12):1576-1590. doi: 10.4252/wjsc.v12.i12.1576. | Learning and Memory Ability | Mechanism |
| 33505601 | The results suggested that the 8-mo-old SAMP8 mice had significant cognitive impairment in learning and memory. | World J Stem Cells. 2020 Dec 26;12(12):1576-1590. doi: 10.4252/wjsc.v12.i12.1576. | Learning and Memory Ability | Mechanism |
| 33505601 | The microenvironment of the hippocampus is closely related to learning and memory function (especially spatial cognitive process). | World J Stem Cells. 2020 Dec 26;12(12):1576-1590. doi: 10.4252/wjsc.v12.i12.1576. | Learning and Memory Ability | Mechanism |
| 33505601 | SAMP8 mice began to show a decline in learning and memory function from an early stage, and particulate matter similar to senile plaque appeared. | World J Stem Cells. 2020 Dec 26;12(12):1576-1590. doi: 10.4252/wjsc.v12.i12.1576. | Learning and Memory Ability | Mechanism |
| 33505601 | Plasticity is the biological basis of learning and memory formation. | World J Stem Cells. 2020 Dec 26;12(12):1576-1590. doi: 10.4252/wjsc.v12.i12.1576. | Learning and Memory Ability | Mechanism |
| 33505601 | The expression of the molecule reflects the number, density, and distribution of synapses and affects learning and memory ability. | World J Stem Cells. 2020 Dec 26;12(12):1576-1590. doi: 10.4252/wjsc.v12.i12.1576. | Learning and Memory Ability | Mechanism |
| 33505601 | The results suggested that Sanjiao acupuncture increases the exogenous expression of synaptophysin in implanted NSCs by improving the hippocampal microenvironment in dementia mice, increasing the number and efficiency of synapses, enhancing the synaptic plasticity, and generating new axons and dendrites to participate in the establishment of new neural networks that regulate the nerve activity, promote the recovery of injured cells, and improve the learning and memory function of dementia mice. | World J Stem Cells. 2020 Dec 26;12(12):1576-1590. doi: 10.4252/wjsc.v12.i12.1576. | Learning and Memory Ability | Mechanism |
| 26279808 | It is due to the combined effects of multiple mechanisms of biochemical chain reaction.The hippocampus and cortex regions of the brain are important and closely associated with learning, memory and sensory-motor functions. | J Korean Neurosurg Soc. 2015 Jul;58(1):14-21. doi: 10.3340/jkns.2015.58.1.14. Epub 2015 Jul 31. | Learning and Memory Ability Motor Function | Mechanism |
| 26279808 | The damage to hippocampus and cerebral cortex result in impairment of learning, memory and sensori-motor functions. | J Korean Neurosurg Soc. 2015 Jul;58(1):14-21. doi: 10.3340/jkns.2015.58.1.14. Epub 2015 Jul 31. | Learning and Memory Ability Motor Function | Mechanism |
| 26279808 | The results of this study shows that brain damage can lead to long-term impairment of learning, memory and sensorimotor function. | J Korean Neurosurg Soc. 2015 Jul;58(1):14-21. doi: 10.3340/jkns.2015.58.1.14. Epub 2015 Jul 31. | Learning and Memory Ability Motor Function | Mechanism |
| 25206919 | Wnt proteins are highly expressed in brain areas involved in learning and memory and vulnerable to damage in Alzheimer's disease, such as the entorhinal cortex and hippocampus. | Neural Regen Res. 2014 May 1;9(9):968-72. doi: 10.4103/1673-5374.133148. | Learning and Memory Ability | Mechanism |
| 25206919 | Previous studies have shown that Shenshu improves impaired learning and memory and it has been suggested as the main acupoint for Alzheimer's disease treatment. | Neural Regen Res. 2014 May 1;9(9):968-72. doi: 10.4103/1673-5374.133148. | Learning and Memory Ability | Mechanism |
| 25206919 | Modern studies have demonstrated that acupuncture and moxibustion at Baihui and Shenshu regulate acetylcholinesterase activity, elevate cortical excitability and cerebral blood flow, improve cerebral circulation, protect against free radical oxidation and neurotoxic injury, suppress inflammation and cell apoptosis, improve learning and memory functions, and effectively treat senile dementia (Mao et al., 2012; Luo et al., 2013). | Neural Regen Res. 2014 May 1;9(9):968-72. doi: 10.4103/1673-5374.133148. | Toxic Side Effects Learning and Memory Ability Circulation Blood Flow | Mechanism |
| 25206919 | The present study demonstrates that electroacupuncture pretreatment has a neuroprotective function in the hippocampus, suggesting that this technique could be used to protect learning and memory functions, and prevent senile dementia. | Neural Regen Res. 2014 May 1;9(9):968-72. doi: 10.4103/1673-5374.133148. | Neuroprotection Learning and Memory Ability | Mechanism |
| 25810743 | Our data suggested that EA treatment improved learning and memory function in the AD rat model partially through downregulating Notch signaling pathway. | Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. | Learning and Memory Ability | Mechanism |
| 25810743 | In the present investigation, we aimed to examine whether EA could affect Aβ-induced apoptosis, synaptic degeneration, and learning and memory deficits in Aβ-injected rats. | Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. | Learning and Memory Ability | Mechanism |
| 25810743 | The behavior function in sham-EA group exhibited a similar pattern to the model group and much worse than that in EA group, indicating that acupoint specificity on learning and memory recovery effect of EA. | Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. | Learning and Memory Ability | Mechanism |
| 25810743 | To better understand the effect of EA on learning and memory recovery, we moved forward to test the expression of Notch signaling pathway related genes for the first time. | Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. | Learning and Memory Ability | Mechanism |
| 25810743 | Notch pathway appears to be involved in neural progenitor regulation, neuronal connectivity, synaptic plasticity, and learning/memory. | Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. | Learning and Memory Ability | Mechanism |
| 25810743 | In conclusion, results from the present study suggested that EA treatment reduced neuronal apoptosis and synaptic degeneration and enhanced learning and memory recovery in the AD model rats possibly through downregulating Notch signaling pathway. | Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. | Learning and Memory Ability | Mechanism |
| 25206816 | Magnetic resonance imaging and functional magnetic resonance imaging revealed that heroin could activate brain areas regulating craving-related reward, learning and memory, cognition and emotion, but acupuncture at Zusanli suppressed the activation of craving-related brain areas. | Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. | Learning and Memory Ability Mood | Mechanism |
| 25206816 | Dopamine acts on dopamine receptors and exerts an important effect on studies into learning and memory, especially when behaviors are related to reward. | Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. | Learning and Memory Ability | Mechanism |
| 25206816 | The nucleus accumbens is strongly associated with learning and memory-related structures such as the prefrontal cortex, hippocampus and amygdale, which possibly indirectly induce the formation of habitual memory via the dorsal striatum, regulates obsessive-compulsive behaviors and generates relapse. | Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. | Learning and Memory Ability | Mechanism |
| 25206816 | Heroin-associated encephalopathy was closely correlated to learning and memory. | Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. | Learning and Memory Ability | Mechanism |
| 25206816 | Drug addiction and learning and memory processes occur in common anatomic structures in the central nervous system. | Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. | Learning and Memory Ability | Mechanism |
| 29636708 | Numerous studies have associated BDNF with reward-related processes, learning and memory, cognitive function, and circuit formation. | Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. | Cognitive Function Learning and Memory Ability | Mechanism |
| 30105072 | Electroacupuncture with traditional Chinese medicine theory may improve spatial learning and memory abilities and glucose metabolism rates in an animal model of AD. | Evid Based Complement Alternat Med. 2018 Jul 12;2018:8296824. doi: 10.1155/2018/8296824. eCollection 2018. | Learning and Memory Ability | Mechanism |
| 30105072 | We have found that electroacupuncture could improve the spatial learning and memory ability and glucose metabolism rate level in an AD animal model. | Evid Based Complement Alternat Med. 2018 Jul 12;2018:8296824. doi: 10.1155/2018/8296824. eCollection 2018. | Learning and Memory Ability | Mechanism |
| 30105072 | After the 15 days of electroacupuncture treatment, the spatial learning and memory abilities and the glucose metabolism rates are improved in the AD model animal. | Evid Based Complement Alternat Med. 2018 Jul 12;2018:8296824. doi: 10.1155/2018/8296824. eCollection 2018. | Learning and Memory Ability | Mechanism |
| 30766475 | The Morris water maze and arterial spin labeling MRI were used to assess spatial learning and memory in behavior and CBF respectively. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | Conclusion: Manual acupuncture can effectively improve the spatial learning, relearning and memory abilities of SAMP8 mice. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | Although the effects of MA on rodent behavior in the Morris water maze have been initially explored and the benign effects of MA on spatial learning and memory has been confirmed, the experimental designs of some prior studies possess significant confounds. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | The current study explores the effects of MA on learning, memory, and CBF with the Morris water maze and arterial spin labeling (ASL) MRI in senescence-accelerated prone mouse 8 (SAMP8) and senescence-accelerated resistant mouse 1 (SAMR1), aiming to assess the interventional efficacy of MA in AD and provide objective imaging evidence. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | To assess learning and memory, the visible platform trial, hidden platform trial, probe trial and the reversal trial were conducted in order. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | The visible platform trial was used to exclude the influence of motivational or sensorimotor factors upon learning and memory performance on day 1. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | As the classic behavioral experiment and de-facto standard for testing hippocampal function in laboratory rodents, the Morris water maze can effectively and objectively evaluate learning and memory ability. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | The Morris water maze has advantages such as minimal training, a lack of food deprivation, insensitivity to differences in body weight and appetite, and repeated testing ability, and has been widely used in behavior testing related to learning and memory in a broad range of neurobiology topics. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | The results indicate a remarkable decline in learning and memory ability in the AD group, in agreement with the typical pathological progression AD. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | The percentage of the time and swimming distance in the NE quadrant in the AD group were both higher compared to the N group (p < 0.01), demonstrating impaired learning and memory abilities in the AD group. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | Both MA and donepezil significantly decreased the escape latency and increased platform crossover number and percentage of time and swimming distance in the SW quadrant (p < 0.01 or p < 0.05), indicating improvements in learning, memory and reversal learning ability with MA which were equal to donepezil. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |
| 30766475 | The prefrontal lobe and hippocampus are necessary for spatial learning and memory, and the hippocampus is the primary substrate of spatial memory abilities and necessary for acquisition, retrieval and consolidation/storage of spatial information. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Learning and Memory Ability | Mechanism |