- The advantages of acupuncture anesthesia in clinical practice
In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.
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Pain Relief
- Cancer Pain
- Acupuncture anesthesia offers effective cancer pain relief, improving the quality of life for cancer patients.
- Pain Relief
- Acupuncture anesthesia provides robust pain relief, reducing the need for postoperative analgesics.
- Analgesic Effect
- Acupuncture anesthesia's analgesic effect offers profound pain relief, particularly beneficial for patients with chronic pain conditions.
- Visceral Pain
- Acupuncture anesthesia can address visceral pain, improving the surgical experience for patients.
- Neuralgia
- Acupuncture anesthesia offers relief from neuralgia, reducing pain and discomfort.
- Inflammatory Pain
- Acupuncture anesthesia's anti-inflammatory properties make it effective in managing inflammatory pain conditions.
Acupuncture anesthesia for Pain Relief-Neuralgia
| PMID | Evidence | Source | Keyword | Type |
|---|---|---|---|---|
| 11075428 | Clinical experience and controlled studies confirmed the efficacy of acupuncture in various pain syndromes (tension headache, migraine, trigeminal neuralgia, posttraumatic pain, lumbar syndrome, ischialgia, etc.) | Wien Med Wochenschr. 2000;150(13-14):278-85. | Neuralgia | Review |
| 12919109 | In the field of dermatology, acupuncture has been reported to be beneficial for the treatment of acne, postherpetic neuralgia, psoriasis, atopic dermatitis, and urticaria. | Dermatol Ther. 2003;16(2):87-92. doi: 10.1046/j.1529-8019.2003.01619.x. | Neuralgia | Review |
| 15458750 | Finally,the efficacy of acupuncture for many musculoskeletal pain syndromes,including spine-related pain, soft tissue pain, neuropathic pain, arthritis of the knee, and upper extremity tendinitis, is reviewed. | Phys Med Rehabil Clin N Am. 2004 Nov;15(4):749-72, v. doi: 10.1016/j.pmr.2004.03.009. | Neuropathic Pain | Review |
| 18954689 | Once neuropathic pain is diagnosed, a trial analgesic or acupuncture session(s) should be prescribed with instructions for owners to observe behavior. | Vet Clin North Am Small Anim Pract. 2008 Nov;38(6):1365-414, vii-viii. doi: 10.1016/j.cvsm.2008.09.001. | Neuropathic Pain | Review |
| 19797006 | For neuropathic pain in SCI, anticonvulsant agents and tricyclic antidepressants often are tried, but these treatments have had limited success in many patients, and alternative interventions (eg, massage therapy, acupuncture, meditation) often are just as successful. | PM R. 2009 Dec;1(12):1077-90. doi: 10.1016/j.pmrj.2009.07.002. | Neuropathic Pain | Review |
| 19887992 | Although its putative mechanisms remain elusive, acupuncture has strong potential as an adjunctive therapy in thalidomide- or bortezomib-induced painful neuropathy, and a better understanding might guide its use in the management of chemotherapy-induced neuropathic pain. | Am J Clin Oncol. 2009 Jun;32(3):319-25. doi: 10.1097/COC.0b013e318173a520. | Neuropathic Pain | Review |
| 20397469 | A survey on acupuncture treatment of trigeminal neuralgia. | J Tradit Chin Med. 2010 Mar;30(1):68-76. doi: 10.1016/s0254-6272(10)60018-0. | Neuralgia | Review |
| 21280460 | A systematic review on acupuncture for trigeminal neuralgia. | Altern Ther Health Med. 2010 Nov-Dec;16(6):30-5. | Neuralgia | Review |
| 21280460 | BACKGROUND: Trigeminal neuralgia (TN) is a commonly seen pain condition with limited treatments available, and acupuncture is widely used for pain conditions, including TN. | Altern Ther Health Med. 2010 Nov-Dec;16(6):30-5. | Neuralgia | Review |
| 21849141 | In the study of acupuncture, researchers have reached certain achievements using differential proteomics to investigate the mechanisms of acupuncture treatment for some diseases, including acute spinal cord injury, ischemic cerebrovascular disease, Parkinson's disease and neuralgia. | Zhong Xi Yi Jie He Xue Bao. 2011 Aug;9(8):819-23. doi: 10.3736/jcim20110802. | Neuralgia | Review |
| 22979925 | Target points: a discussion on acupuncture treatment of primary trigeminal neuralgia. | Zhong Xi Yi Jie He Xue Bao. 2012 Sep;10(9):961-5. doi: 10.3736/jcim20120902. | Neuralgia | Review |
| 22979925 | This study summarized the method of using acupuncture at Xiaguan (ST7), Cuanzhu (BL2), Sibai (ST2) and Jiachengjiang acupoints to align with the spheno-palatine ganglion and additional nerve foramen (supraorbital, infraorbital and mental foramina) to treat primary trigeminal neuralgia. | Zhong Xi Yi Jie He Xue Bao. 2012 Sep;10(9):961-5. doi: 10.3736/jcim20120902. | Neuralgia | Review |
| 24215919 | The regulation of neurotrophins' expression and activity is one of the possible neurophysiological mechanisms underlying acupuncture's effects on neuropathic pain, nerve injury, neurodegeneration, and even in the regulation of gonadal functions. | Int Rev Neurobiol. 2013;111:91-124. doi: 10.1016/B978-0-12-411545-3.00005-5. | Neuropathic Pain | Review |
| 27062944 | In this review, we address the feasibility of a combined acupuncture and pharmacotherapy treatment for the relief of neuropathic pain behavior following SCI. | Complement Ther Med. 2016 Apr;25:27-33. doi: 10.1016/j.ctim.2015.12.021. Epub 2016 Jan 6. | Neuropathic Pain | Review |
| 29071937 | Involvement of Central Neuroglia Cells in Analgesic Effect of Electroacupuncture Therapy for Neuropathic Pain. | Zhen Ci Yan Jiu. 2016 Aug 25;41(4):369-372. | Analgesic Effect Neuropathic Pain | Review |
| 30236409 | Studies, both laboratory and clinical, support the use of acupuncture in the management of neurologic conditions in small animals, specifically in cases of intervertebral disc disease, other myelopathies, and neuropathic pain conditions. | Top Companion Anim Med. 2018 Jun;33(2):49-57. doi: 10.1053/j.tcam.2018.04.002. Epub 2018 May 16. | Neuropathic Pain | Review |
| 30522140 | Nonpharmacologic therapies that have been utilized in the management of neuropathic pain include acupuncture, massage therapy, and reflexology. | Semin Neurol. 2018 Dec;38(6):644-653. doi: 10.1055/s-0038-1673679. Epub 2018 Dec 6. | Neuropathic Pain | Review |
| 30712736 | Acupuncture for primary trigeminal neuralgia: A systematic review and PRISMA-compliant meta-analysis. | Complement Ther Clin Pract. 2019 Feb;34:254-267. doi: 10.1016/j.ctcp.2018.12.013. Epub 2018 Dec 24. | Neuralgia | Review |
| 30712736 | BACKGROUND AND PURPOSE: Acupuncture is increasingly used by patients with primary trigeminal neuralgia (PTN). | Complement Ther Clin Pract. 2019 Feb;34:254-267. doi: 10.1016/j.ctcp.2018.12.013. Epub 2018 Dec 24. | Neuralgia | Review |
| 31074875 | Evidence for nutritional interventions, exercise, supplements, acupuncture, and mindfulness-based practices in the treatment of neuropathic pain is encouraging. | Muscle Nerve. 2019 Aug;60(2):124-136. doi: 10.1002/mus.26510. Epub 2019 May 30. | Neuropathic Pain | Review |
| 32609651 | Experimental studies across nociplastic and neuropathic pain conditions and across pharmacological and acupuncture treatments investigated psychological and neurobiological mechanisms underlying these effects. | Scand J Pain. 2020 Jul 28;20(3):451-467. doi: 10.1515/sjpain-2019-0183. | Neuropathic Pain | Review |
| 32891279 | Effectiveness of press needle treatment and electroacupuncture in patients with postherpetic neuralgia: A matched propensity score analysis. | Complement Ther Clin Pract. 2020 Aug;40:101202. doi: 10.1016/j.ctcp.2020.101202. Epub 2020 May 25. | Neuralgia | Review |
| 35249352 | DISCUSSIONS: Compared to Western medicine treatments, acupuncture had a better effect on HZ, reduced the posterior neuralgia rate of patients, and shortened the course of treatment, but had no obvious effect on the relief of pain. | Ann Palliat Med. 2022 Feb;11(2):756-765. doi: 10.21037/apm-22-109. | Neuralgia Pain Relief | Review |
| 35459333 | Currently, according to the National Comprehensive Cancer Network (NCCN) guidelines, the following symptoms are indicated for acupuncture treatment: pain including neuropathic pain, arthralgia, and myalgia, especially in the aromatase inhibitors therapy, nausea, and vomiting, fatigue, vasomotor symptoms in women and vasomotor symptoms in men caused by androgen deprivation therapy. | Klin Onkol. 2022 Spring;35(2):94-99. doi: 10.48095/ccko202294. | Neuropathic Pain Nausea and Vomiting | Review |
| 35695033 | Acupuncture plus methylcobalamin showed more favorable effects than methylcobalamin alone in relieving neuralgia, restoring nerve conduction velocity and improving quality of life. | Acupunct Med. 2023 Apr;41(2):73-85. doi: 10.1177/09645284221076512. Epub 2022 Jun 12. | Neuralgia | Review |
| 35916732 | A single acupuncture treatment in rodents had an analgesic effect, which was more effective in inflammatory pain than in neuropathic pain in the early phase of treatment. | Pain Med. 2023 Jan 4;24(1):11-24. doi: 10.1093/pm/pnac115. | Analgesic Effect Neuropathic Pain Inflammatory Pain | Review |
| 35916732 | Furthermore, acupuncture treatment could effectively inhibit the activity of astrocytes and microglia in both inflammatory pain and neuropathic pain in a time-course pattern. | Pain Med. 2023 Jan 4;24(1):11-24. doi: 10.1093/pm/pnac115. | Neuropathic Pain Inflammatory Pain | Review |
| 36535605 | The effect of acupuncture on chemotherapy-induced pain (SMD - 2.09; 95% CI: -4.27-0.09; p = 0.06) and electromagnetic stimulation on diabetic neuropathic pain (Hedges' g - 0.77; 95% CI: -1.82-0.27; p = 0.15) were insignificant. | Contemp Clin Trials. 2023 Feb;125:107055. doi: 10.1016/j.cct.2022.107055. Epub 2022 Dec 16. | Neuropathic Pain | Review |
| 31074875 | Evidence for nutritional interventions, exercise, supplements, acupuncture, and mindfulness-based practices in the treatment of neuropathic pain is encouraging. | Muscle Nerve. 2019 Aug;60(2):124-136. doi: 10.1002/mus.26510. Epub 2019 May 30. | Neuropathic Pain | Review |
| 36862302 | This review examines the current literature on integrative health modalities (anti-inflammatory diets, functional movement, acupuncture, meditation, and transcutaneous therapy) for treating patients with neuropathic pain. | Curr Pain Headache Rep. 2023 Apr;27(4):49-55. doi: 10.1007/s11916-023-01102-9. Epub 2023 Mar 2. | Neuropathic Pain Motor Function | Review |
| 36862302 | RECENT FINDINGS: The use of an anti-inflammatory diet, functional movement, acupuncture, meditation, and transcutaneous therapy in treating neuropathic pain has been investigated in prior literature with positive outcomes. | Curr Pain Headache Rep. 2023 Apr;27(4):49-55. doi: 10.1007/s11916-023-01102-9. Epub 2023 Mar 2. | Neuropathic Pain Motor Function | Review |
| 37159979 | Acupuncture for the treatment of trigeminal neuralgia: A systematic review and meta-analysis. | Complement Ther Clin Pract. 2023 Aug;52:101763. doi: 10.1016/j.ctcp.2023.101763. Epub 2023 May 2. | Neuralgia | Review |
| 37159979 | BACKGROUND AND PURPOSE: Few systematic reviews have examined the effects of acupuncture on trigeminal neuralgia. | Complement Ther Clin Pract. 2023 Aug;52:101763. doi: 10.1016/j.ctcp.2023.101763. Epub 2023 May 2. | Neuralgia | Review |
| 37159979 | This review aims to provide up-to-date evidence on the efficacy of acupuncture for managing pain in patients with trigeminal neuralgia. | Complement Ther Clin Pract. 2023 Aug;52:101763. doi: 10.1016/j.ctcp.2023.101763. Epub 2023 May 2. | Neuralgia | Review |
| 37159979 | CONCLUSION: Although the quality of evidence is low, compared with carbamazepine, acupuncture may improve trigeminal neuralgia-related pain. | Complement Ther Clin Pract. 2023 Aug;52:101763. doi: 10.1016/j.ctcp.2023.101763. Epub 2023 May 2. | Neuralgia | Review |
| 37159979 | Further rigorously designed studies are warranted to confirm the effects of acupuncture on patients with trigeminal neuralgia. | Complement Ther Clin Pract. 2023 Aug;52:101763. doi: 10.1016/j.ctcp.2023.101763. Epub 2023 May 2. | Neuralgia | Review |
| 37382085 | CONCLUSION: Based on this analysis, it is concluded that acupuncture is safe and there is evidence of the reduction of gastrointestinal symptoms, chemotherapy-induced peripheral neuropathy, pain, dry mouth, fatigue, insomnia, and improvement of cognitive capacity. | J Clin Nurs. 2023 Oct;32(19-20):6917-6933. doi: 10.1111/jocn.16812. Epub 2023 Jun 29. | Neuropathic Pain Insomnia | Review |
| 37805054 | Effects of acupuncture therapy in diabetic neuropathic pain: A systematic review and meta-analysis. | Complement Ther Med. 2023 Nov;78:102992. doi: 10.1016/j.ctim.2023.102992. Epub 2023 Oct 5. | Neuropathic Pain | Review |
| 37805054 | OBJECTIVE: To evaluate the effectiveness of acupuncture in relieving diabetic neuropathic pain and to establish a more reliable and efficient foundation for acupuncture practice in diabetes care. | Complement Ther Med. 2023 Nov;78:102992. doi: 10.1016/j.ctim.2023.102992. Epub 2023 Oct 5. | Neuropathic Pain | Review |
| 38212497 | Different Acupuncture Therapies for Postherpetic Neuralgia: An Overview of Systematic Reviews and Meta-analysis. | Chin J Integr Med. 2024 Jan 12. doi: 10.1007/s11655-023-3613-4. | Neuralgia | Review |
| 23338773 | In this study, cancer patients suffering from chronic neuropathic pain were treated with a specific auricular acupuncture implants as the study group, while noninvasive seeds was used as the placebo group. | Curr Pain Headache Rep. 2013 Mar;17(3):321. doi: 10.1007/s11916-013-0321-3. | Neuropathic Pain | Review |
| 35313481 | Although the analgesic effect of the acupuncture group was superior to the control groups, it cannot be neglected that on the management of some pain (pain in labor, migraine, and neuropathic pain), low-quality evidence suggests that acupuncture does not differ much from usual care. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Neuropathic Pain | Review |
| 24322588 | Manual acupuncture or a local injection of the adenosine A1 receptor agonist 2-chloro-N(6)-cyclopentyladenosine at acupoint ST36 significantly inhibits mechanical allodynia and thermal hyperalgesia in wild-type but not in adenosine A1 receptor knockout mice with inflammatory and neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Interestingly, CCKa receptor-deficient rats with neuropathic pain showed more robust response to electroacupuncture treatment than did normal rats. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Although mechanisms of acupuncture analgesia have been investigated at each level of the pain pathway in inflammatory pain models, acupuncture analgesia has been studied mainly at the spinal level in neuropathic pain models and shows involvement of opioids, serotonin, norepinephrine, amino acids, and glia cell/cytokines. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain Inflammatory Pain | Review |
| 24322588 | Spinal opioids are involved in electroacupuncture inhibition of neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Systemic administration of naloxone blocked 2 Hz electroacupuncture inhibition of L5 and L6 spinal nerve ligation (SNL)- and caudal trunk nerve injury-induced neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Manual acupuncture, applied at ST36 and SP6 in an SNL-induced neuropathic pain rat model, significantly reduced SNL-induced hypersensitivity; this effect was blocked by systemic nolaxone. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Clearly, μ, δ, and κ receptors are involved in 10 Hz electroacupuncture inhibition of chemotherapy-induced neuropathic pain; this is different from the opioid involvement in electroacupuncture inhibition of peripheral tissue injury-caused inflammatory pain, in which only μ and δ receptors participate. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain Inflammatory Pain | Review |
| 24322588 | Low frequency electroacupuncture inhibits neuropathic pain more effectively than does high frequency electroacupuncture. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Similarly, 2 Hz electroacupuncture, in a caudal trunk nerve injury-induced neuropathic pain model, induced a robust and longer lasting inhibitory effect on mechanical allodynia assessed with a von Frey filament (bending force: 2 g) than did 100 Hz. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Spinal serotonin and norepinephrine participate in electroacupuncture inhibition of neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | These data show that spinal α2-adrenoceptors, 5-HT1ARs, and 5-HT3Rs are involved in electroacupuncture inhibition of cold allodynia in neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Although α2-adrenoceptors and 5-HT1ARs are involved in electroacupuncture inhibition of both inflammatory and neuropathic pain, 5-HT3Rs play a role in electroacupuncture inhibition of neuropathic but not inflammatory pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain Inflammatory Pain | Review |
| 24322588 | These data lead us to hypothesize that electroacupuncture activates 5-HT1ARs to inhibit NMDAR activities, thus attenuating neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Interestingly, electroacupuncture attenuates both inflammatory and neuropathic pain by activating spinal α2-adrenoceptors and 5-HT1ARs and inhibiting GluN1 (fig. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Both excitatory amino acids and inhibitory amino acids play roles in electroacupuncture attenuation of neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Glial cell and cytokines participate in electroacupuncture inhibition of neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Electroacupuncture significantly enhanced expression of somatostatin, GDNF, and the GDNF family receptor GFRα-1 (the high-affinity receptor of GDNF) in DRG and the spinal dorsal horn in rats with neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Moreover, electroacupuncture has been shown to inhibit P2Ã3 to attenuate neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Overall, electroacupuncture induces numerous bioactive chemicals that have inhibited neuropathic pain in several rat models (fig. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Whether and how it modulates supraspinal and peripheral nerve activities, which might be responsible for electroacupuncture inhibition of neuropathic pain, have not been investigated as yet. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Ten Hz electroacupuncture produces longer alleviation of inflammatory pain and more powerful inhibition of neuropathic pain than does 100 Hz electroacupuncture. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain Inflammatory Pain | Review |
| 24322588 | Electroacupuncture mechanisms on neuropathic pain have been studied mainly at the spinal level, less so at the supraspinal level and peripheral sites. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 24322588 | Most bioactive chemicals involved in electroacupuncture inhibition of inflammatory pain are also implicated in electroacupuncture inhibition of neuropathic pain (table 1, fig. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain Inflammatory Pain | Review |
| 24322588 | Second, as summarized in table 1, although many bioactive chemicals in the spinal cord participate in electroacupuncture inhibition of inflammatory and neuropathic pain, it is unclear whether these chemicals play similar roles in the brain; the peripheral mechanisms of electroacupuncture inhibition of neuropathic pain and the mechanisms of electroacupuncture inhibition of cancer pain are not well studied. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain Cancer Pain | Review |
| 24322588 | Mechanisms of electroacupuncture inhibition of inflammatory and neuropathic pain. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Neuropathic Pain | Review |
| 25379462 | There are several case reports and case series in Chinese literature on successful acupuncture (éç¸ ZhÄn JiÇ) treatment for patients with trigeminal neuralgia. | J Tradit Complement Med. 2014 Oct;4(4):218-23. doi: 10.4103/2225-4110.139113. | Neuralgia | Review |
| 26652982 | In another pilot study by Bao et al, 27 multiple myeloma patients with moderate to severe bortezomib-induced peripheral neuropathy experienced significantly reduced neuropathic pain and improved functioning following 10 weeks of acupuncture treatment (twice weekly for 2 weeks, once weekly for 4 weeks, and then biweekly for 4 weeks). | Crit Rev Oncol Hematol. 2016 Feb;98:325-34. doi: 10.1016/j.critrevonc.2015.11.014. Epub 2015 Nov 23. | Neuropathic Pain | Review |
| 28664077 | Diluted bee venom acupuncture enhanced clonidine-induced analgesia significantly in both the mouse formalin test and the rat chronic constriction injury neuropathic pain model, suggesting that a combination of low-dose clonidine and acupuncture therapy decreases the side effects of clonidine. | Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. | Neuropathic Pain Side Effects | Review |
| 29234385 | However, the efficacy of acupuncture as a treatment of pain in other pain conditions such as neuropathic pain or fibromyalgia remains inconclusive. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Neuropathic Pain | Review |
| 29234450 | Studies performed on animals have shown that acupuncture can significantly relieve behavioral signs such as hyperalgesia and allodynia in peripheral nerve injury-induced neuropathic pain models. | Evid Based Complement Alternat Med. 2017;2017:9785345. doi: 10.1155/2017/9785345. Epub 2017 Oct 18. | Neuropathic Pain | Review |
| 30117343 | The analgesic effect of acupuncture on chronic neuropathic pain has been shown to be mediated by P2 X3 receptors of purinergic signaling and is identified with specific neurons that are activated via stimulation of ATP flux in the brains of rat animal models. | Integr Cancer Ther. 2018 Sep;17(3):602-618. doi: 10.1177/1534735418786801. | Analgesic Effect Neuropathic Pain | Review |
| 30142834 | Acupuncture for postherpetic neuralgia | Medicine (Baltimore). 2018 Aug;97(34):e11986. doi: 10.1097/MD.0000000000011986. | Neuralgia | Review |
| 30142834 | Acupuncture is widely used for postherpetic neuralgia (PHN) in China but its effect is unclear. | Medicine (Baltimore). 2018 Aug;97(34):e11986. doi: 10.1097/MD.0000000000011986. | Neuralgia | Review |
| 30984277 | In clinical settings, acupuncture can be used to treat headache, neuropathic pain, low back pain, osteoarthritis, and irritable bowel syndrome. | Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. | Neuropathic Pain | Review |
| 30984277 | This effect explains why acupuncture can be widely used for treating neuropathic pain. | Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. | Neuropathic Pain | Review |
| 30984277 | Many reports found that acupuncture can relieve neuropathic pain induced by postherpetic, multiple sclerosis, cancer and anticancer treatment, etc. | Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. | Neuropathic Pain | Review |
| 30984277 | In summary, the mechanisms though which acupuncture alleviates neuralgia mainly involve the enhancement of the descending inhibition pathway, including the release of opioids and the inhibition of NMDA. | Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. | Neuralgia | Review |
| 30984277 | Therefore, acupuncture is beneficial for the treatment of headache, neuropathic pain, low back pain, osteoarthritis, and irritable bowel syndrome. | Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. | Neuropathic Pain | Review |
| 31467579 | Antineuropathic Pain Effects of Electroacupuncture | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Neuropathic Pain | Review |
| 31467579 | used electroacupuncture to stimulate the pain threshold in rats with diabetic neuropathic pain and showed that electroacupuncture can not only increase the pain threshold of DNP rats but also reduce blood glucose level. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Neuropathic Pain | Review |
| 31467579 | For chronic neuropathic pain, multiple electroacupuncture can increase the activity of Ras/Raf/ERK signaling pathway and the expression of p38MAPK, which indicates that the cumulative effect of electroacupuncture may be associated with the changes in the Ras/Raf/ERK signaling pathway and the expression of p38MAPK to achieve the analgesic effects. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect Neuropathic Pain | Review |
| 31467579 | Deng G and Jiang S have revealed the role of electroacupuncture in neuroprotection and neuropathic pain in specific acupoints, and studies by Deng G et al. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Neuroprotection Neuropathic Pain | Review |
| 31467579 | However, the study of electroacupuncture against neuropathic pain does not involve the MAPK signaling pathway, and whether it is correlated with the MAPK signaling pathway remains to be evaluated by further study. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Neuropathic Pain | Review |
| 31680841 | For example, acupuncture therapeutic brain imaging studies in neuropathic pain (carpal tunnel syndrome) showed distinct true acupuncture-related neuroplasticity in the somatosensory cortex. | Front Neurosci. 2019 Oct 17;13:1110. doi: 10.3389/fnins.2019.01110. eCollection 2019. | Neuropathic Pain | Review |
| 32493452 | The effects of acupuncture on occipital neuralgia: a systematic review and meta-analysis | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | This systematic review aims to assess the level of evidence in randomized controlled trials (RCTs) on the effects of acupuncture on occipital neuralgia. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | Of the various TOM treatments which include acupuncture, pharmacoacupuncture, acupotomy, and chuna (tuina) therapy, acupuncture has been reported to be better than drugs at treating occipital neuralgia in terms of pain relief and effective rate. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia Pain Relief | Review |
| 32493452 | Since acupuncture can be considered as an alternative treatment method to avoid the adverse effects of typical medication using anti-inflammatory analgesics and anti-depressants, we believe that acupuncture can be an important treatment for occipital neuralgia. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia Adverse Reactions | Review |
| 32493452 | Studies on the effects of acupuncture on occipital neuralgia have mostly consisted of case studies and RCTs. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | A large number of occipital neuralgia patients have been treated using acupuncture at TOM institutions in Korea, but there are relatively few papers providing evidence for the effects of acupuncture, and there has still been no systematic review either domestically or overseas. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | Hence, in this paper, we aimed to conduct a systematic review of previous clinical trials using acupuncture to treat occipital neuralgia, in order to explore and present evidence for the effects of acupuncture. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | We selected search terms to search for studies related to acupuncture treatment for occipital neuralgia. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | We used base search terms referring to the primary intervention, acupuncture, and the disease of interest, i.e., occipital neuralgia; then, among the retrieved studies, two authors (JM and SH) independently selected studies to include in the analysis based on a review of the title, abstract, and main text. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | This was a systematic literature review of studies examining the effects of acupuncture on occipital neuralgia. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | We first excluded 72 duplicate studies; after reviewing the titles and abstracts, a further 161 studies were excluded because they were not related to acupuncture, because the patients did not have occipital neuralgia, because they were not in the form of academic papers, because we were unable to access the main text, or because they were not RCTs. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | In TOM, occipital neuralgia is treated using methods with few adverse effects, such as acupuncture, electroacupuncture, pharmacoacupuncture, moxibustion, and chuna manual therapy. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia Adverse Reactions | Review |
| 32493452 | Currently, TOM institutions treat large numbers of occipital neuralgia patients using acupuncture, moxibustion, electroacupuncture, and chuna, and patients who have received conventional medicine, such as medication, but experienced no improvement in symptoms often visit TOM institutions. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | However, the mechanisms of acupuncture in occipital neuralgia remain unclear, and research investigating the effects of TOM, including acupuncture, on occipital neuralgia are still limited to RCTs. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | Hence, in this study, in order to improve the level of evidence for acupuncture, which can be considered an effective treatment modality with few adverse effects, we conducted a systematic literature review and meta-analysis of studies investigating the effects of acupuncture on occipital neuralgia. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia Adverse Reactions | Review |
| 32493452 | This indicates that the type of acupuncture points is more important than the number of acupuncture points when treating occipital neuralgia. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | This suggests that acupuncture treatment for more than 2 weeks might be most effective in occipital neuralgia. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | Even though a large number of worldwide doctors are treating occipital neuralgia patients with acupuncture in clinical practice, in addition to traditional Korean medicine practitioners in Korea, little research is being conducted in this area, and so we were unable to analyze studies from countries other than China. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | Thus, in the future, research on acupuncture treatment for occipital neuralgia will need to be performed in more countries. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | This study has value as the first systematic literature review and meta-analysis providing evidence of the effects of acupuncture in treating occipital neuralgia. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32493452 | We expect that our data could be used in acupuncture research and clinical practice for occipital neuralgia, and we believe that further, high-quality studies will be required in this field. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Neuralgia | Review |
| 32630156 | reported that acupuncture stimulates adenosine A1 receptor and induces adenosine release, thus relieving inflammation and neuropathic pain, which was not observed in mice lacking adenosine A1 receptors. | Int J Mol Sci. 2020 Jun 30;21(13):4693. doi: 10.3390/ijms21134693. | Neuropathic Pain | Review |
| 32875921 | Acupuncture may relieve neuropathic pain by improving central neurotransmission of GABA-ergic, serotoninergic, and adrenergic. | Integr Cancer Ther. 2020 Jan-Dec;19:1534735420945027. doi: 10.1177/1534735420945027. | Neuropathic Pain | Review |
| 32992601 | Moreover, bee venom acupuncture has been commonly used for clinical disorders such as Parkinson disease, neuropathic pain, Alzheimer disease, intervertebral disc disease, spinal cord injury, musculoskeletal pain, arthritis, multiple sclerosis, skin disease and cancer. | Toxins (Basel). 2020 Sep 27;12(10):618. doi: 10.3390/toxins12100618. | Neuropathic Pain | Review |
| 33531894 | As shown in Table 1, the neuropathic pain models, including pain generated by chronic constriction injury, chemotherapy-induced pain, spinal nerve ligation, and spinal cord injury, have been widely used in the study of central sensitization-mediated acupuncture analgesia. | Neural Plast. 2021 Jan 18;2021:8881557. doi: 10.1155/2021/8881557. eCollection 2021. | Neuropathic Pain | Review |
| 33883931 | Acupuncture has been proven to be an effective analgesic intervention in management of diverse types of pain, such as inflammatory pain, visceral pain, cancer pain, and neuropathic pain, including chemotherapy-induced neuropathic pain. | J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. | Analgesic Effect Visceral Pain Neuropathic Pain Cancer Pain Inflammatory Pain | Review |
| 33883931 | In brief, the mechanisms of acupuncture on attenuating paclitaxel-induced neuropathic pain have been studied mainly at peripheral and spinal levels but not at supra-spinal level by using rodent models of PIPN to date. | J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. | Neuropathic Pain | Review |
| 33883931 | Novel attempts using acupuncture have been reported to ameliorate paclitaxel-induced neuropathic pain in both clinical and basic studies. | J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. | Neuropathic Pain | Review |
| 34010229 | In patients with neuropathic pain, cutaneous nerve blocks, TENS, botulinum toxin, and acupuncture have been used to treat pain of central origin, while autologous serum tears (AST) and amniotic membrane transplant (AMT) have been used to treat pain of peripheral origin. | Curr Opin Ophthalmol. 2021 Jul 1;32(4):348-361. doi: 10.1097/ICU.0000000000000768. | Neuropathic Pain | Review |
| 34069357 | This approach has shown to inhibit nociception in CCI models of neuropathic pain lending support to the common acupuncture practices for sciatica. | J Clin Med. 2021 May 19;10(10):2189. doi: 10.3390/jcm10102189. | Neuropathic Pain | Review |
| 34093111 | However, except for the neuropathic pain mostly applied in the skin to explore the central mechanisms of acupuncture analgesia, the muscle and visceral pain using specific stimulations deserve more attention to broaden the recognition of acupuncture analgesia in the experimental pain. | Front Neurosci. 2021 May 20;15:648305. doi: 10.3389/fnins.2021.648305. eCollection 2021. | Visceral Pain Neuropathic Pain | Review |
| 34336626 | After acupuncture was introduced to places outside of China and started to gain popularity, many studies have been conducted to determine if there is a benefit in the use of acupuncture in things such as urinary tract infections, neuropathic pain, peripheral neuropathy, hip osteoarthritis, cerebellum balancing, allergic rhinitis, treatment of hypolactation, depression, gynecological conditions, migraine, chronic prostatitis, and post stroke spastic hemiplegia. | Anesth Pain Med. 2021 Apr 3;11(2):e113627. doi: 10.5812/aapm.113627. eCollection 2021 Apr. | Neuropathic Pain Depression | Review |
| 34397828 | Acupuncture and moxibustion combined with cupping for the treatment of post-herpetic neuralgia | Medicine (Baltimore). 2021 Aug 6;100(31):e26785. doi: 10.1097/MD.0000000000026785. | Neuralgia | Review |
| 34397828 | There are still controversies between the curative effect of acupuncture combined with cupping therapy and western medicine for post-herpetic neuralgia (PHN). | Medicine (Baltimore). 2021 Aug 6;100(31):e26785. doi: 10.1097/MD.0000000000026785. | Neuralgia | Review |
| 34397828 | The English search terms are as follows:(((((Fire-needle[Title/Abstract]) OR (Fire needle[Title/Abstract])) OR (electroacupuncture[Title/Abstract])) OR (acupuncture[Title/Abstract])) AND (cupping[Title/Abstract])) AND (((Shingles[Title/Abstract]) OR (Neuralgia after herpes zoster[Title/Abstract])) OR (PHN[Title/Abstract])). | Medicine (Baltimore). 2021 Aug 6;100(31):e26785. doi: 10.1097/MD.0000000000026785. | Neuralgia | Review |
| 34437474 | At present, the analgesic effect of acupuncture by inhibiting the release of SP has been confirmed by several studies, such as in the treatment of ischioneuralgia, knee osteoarthritis, lumbar disc herniation and other diseases. | Vet Sci. 2021 Jul 30;8(8):149. doi: 10.3390/vetsci8080149. | Analgesic Effect Neuralgia | Review |
| 34456996 | Indeed, acupuncture's function to reshape the brain is not limited to stroke, as a recent review of brain plasticity in animals revealed that acupuncture could modulate the plasticity of various central nervous systems, such as depression, neuropathic pain, Alzheimer's disease, and cerebral vascular disorders. | Neural Plast. 2021 Aug 19;2021:2662585. doi: 10.1155/2021/2662585. eCollection 2021. | Neuropathic Pain Depression | Review |
| 34667434 | The authors concluded that acupuncture can improve several symptoms associated with bortezomib-induced CIPN, particularly numbness and tingling in hands and feet, cold sensitivity, and an unpleasant feeling, but larger studies are needed to assess the impact of acupuncture on neuropathic pain. | Contemp Oncol (Pozn). 2021;25(2):88-94. doi: 10.5114/wo.2021.105969. Epub 2021 May 7. | Neuropathic Pain | Review |
| 34729102 | A case report suggested that acupuncture may greatly improve the neuropathic pain induced by bone metastasis in patients with advanced cancer. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Neuropathic Pain | Review |
| 34916843 | Modern medical studies have shown that acupuncture significantly affects migraine, knee osteoarthritis, neck pain, neuropathic pain, and chronic stable angina. | J Pain Res. 2021 Dec 10;14:3773-3789. doi: 10.2147/JPR.S340961. eCollection 2021. | Neuropathic Pain | Review |
| 34916843 | FMRI studies on acupuncture analgesia involved 16 diseases, of which lower back pain (52 articles) was the hot spot, followed by migraine (30 articles), cancer pain (17 articles), chronic pain (12 articles), neuropathic pain (9 articles), back pain (8 articles), stomach pain (8 articles), osteoarthritis (7 articles), shoulder pain (6 articles), headache (6 articles), irritable bowel syndrome (6 articles), neck pain (5 articles), radicular pain (5 articles) pelvic pain (2 articles), tennis elbow pain (2 articles), heel pain (1 article), and leg pain (1 article). | J Pain Res. 2021 Dec 10;14:3773-3789. doi: 10.2147/JPR.S340961. eCollection 2021. | Neuropathic Pain Cancer Pain | Review |
| 35140516 | Recent studies have demonstrated the potential benefits of acupuncture in improving neuropathic pain features and pain catastrophizing in FM patients, as well as the possibility of personalization of treatment. | J Pain Res. 2022 Feb 3;15:315-329. doi: 10.2147/JPR.S351320. eCollection 2022. | Neuropathic Pain | Review |
| 35237333 | Acupuncture Methods for Primary Trigeminal Neuralgia: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials | Evid Based Complement Alternat Med. 2022 Feb 21;2022:3178154. doi: 10.1155/2022/3178154. eCollection 2022. | Neuralgia | Review |
| 35313481 | Although the analgesic effect of the acupuncture group was superior to the control groups, it cannot be neglected that on the management of some pain (pain in labor, migraine, and neuropathic pain), low-quality evidence suggests that acupuncture does not differ much from usual care. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Neuropathic Pain | Review |
| 35341147 | Acupuncture and Moxibustion for Peripheral Neuropathic Pain: A Frequentist Network Meta-Analysis and Cost-Effectiveness Evaluation | Evid Based Complement Alternat Med. 2022 Mar 16;2022:6886465. doi: 10.1155/2022/6886465. eCollection 2022. | Neuropathic Pain | Review |
| 35341147 | Acupuncture and moxibustion techniques have been increasingly used to treat peripheral neuropathic pain (PNP). | Evid Based Complement Alternat Med. 2022 Mar 16;2022:6886465. doi: 10.1155/2022/6886465. eCollection 2022. | Neuropathic Pain | Review |
| 35341147 | However, the potential therapeutic role of acupuncture and associated techniques in peripheral neuropathic pain (PNP) have been widely assessed experimentally and clinically exhibiting promising results. | Evid Based Complement Alternat Med. 2022 Mar 16;2022:6886465. doi: 10.1155/2022/6886465. eCollection 2022. | Neuropathic Pain | Review |
| 35462893 | reported that HSP 90 participates in electroacupuncture-induced analgesia in chronic neuropathic pain. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Neuropathic Pain | Review |
| 35462893 | Electroacupuncture can inhibit P2X7 receptor-mediated microglial activation and attenuate neuropathic pain. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Neuropathic Pain | Review |
| 35462893 | In addition, acupuncture reduces diabetic peripheral neuralgia by downregulating the P2X4 expression in rat spinal microglia. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Neuralgia | Review |
| 35462893 | Acupuncture alleviates the neurogenic bladder, chronic shoulder pain, neuropathic pain, and osteoporosis and improves neurological (sensory and motor) functions. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Neuropathic Pain Motor Function | Review |
| 35737304 | However, acupuncture induces beneficial neuroplasticity that prevents or reverses the changes caused by chronic neuropathic pain. | Vet Sci. 2022 May 26;9(6):252. doi: 10.3390/vetsci9060252. | Neuropathic Pain | Review |
| 35768044 | The control population was defined as a cohort of animals in which the same neuropathic pain model was induced, but who did either receive no treatment or a sham intervention (eg, electroacupuncture without electrical stimulation). | J Pain. 2022 Nov;23(11):1833-1855. doi: 10.1016/j.jpain.2022.06.007. Epub 2022 Jun 26. | Neuropathic Pain | Review |
| 35768044 | Human evidence for the effect of electroacupuncture on neuropathic pain remains controversial. | J Pain. 2022 Nov;23(11):1833-1855. doi: 10.1016/j.jpain.2022.06.007. Epub 2022 Jun 26. | Neuropathic Pain | Review |
| 35768044 | Penza et al did not find pain improvements following electroacupuncture treatment in patients with neuropathic pain whereas Galantino et al reported some improvement in patients with human immunodeficiency virus-related peripheral neuropathy. | J Pain. 2022 Nov;23(11):1833-1855. doi: 10.1016/j.jpain.2022.06.007. Epub 2022 Jun 26. | Immunity Neuropathic Pain | Review |
| 35768044 | In line with our preclinical findings, a Cochrane review about the use of acupuncture in humans with any type of neuropathic pain reports limited evidence. | J Pain. 2022 Nov;23(11):1833-1855. doi: 10.1016/j.jpain.2022.06.007. Epub 2022 Jun 26. | Neuropathic Pain | Review |
| 35768044 | Our results suggest that exercises, electro-acupuncture, neural mobilization, and physical agents modulate biomarkers of neuropathic pain in preclinical models. | J Pain. 2022 Nov;23(11):1833-1855. doi: 10.1016/j.jpain.2022.06.007. Epub 2022 Jun 26. | Neuropathic Pain | Review |
| 36034938 | Effects of Acupuncture on Neuropathic Pain Induced by Spinal Cord Injury: A Systematic Review and Meta-Analysis | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Acupuncture has been widely used for neuropathic pain after SCI in clinical settings. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Thus, this study aimed to conduct a systematic review and meta-analysis to assess the efficacy of acupuncture on SCI-induced neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Six randomized controlled trials (145 participants in the experimental groups and 141 participants in the control groups) were identified that evaluated the application of acupuncture for neuropathic pain after SCI and were included in this study. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Subgroup analyses indicated that electroacupuncture (EA) had better effects on SCI-induced neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Available evidence appears to suggest that acupuncture may have a role in SCI-induced neuropathic pain management, but this remains to be determined. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Recently years, acupuncture has been widely used for patients with SCI, not only for neurological dysfunction but also for neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | However, the clinical efficacy of acupuncture in SCI-induced neuropathic pain remains uncertain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | To date, many clinical studies on the treatment of neuropathic pain with acupuncture have been reported. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | However, no relevant systematic reviews or meta-analyses have been performed to address the efficacy of acupuncture in SCI-induced neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Therefore, we conducted a systematic review and meta-analysis to evaluate the effectiveness of acupuncture in treating neuropathic pain after SCI. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | This study may help to provide guidelines for future prospective clinical application of acupuncture therapy for neuropathic pain subsequent to SCI. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | We systematically searched the following seven electronic databases from inception to 30 September 2021: PubMed, the Cochrane Library, the Web of Science, the China National Knowledge Infrastructure (CNKI), the Chinese Biomedical Literature Service System (SinoMed), the Wan-fang Database, and the Chinese Scientific Journals Database (VIP), to identify all randomized control trials (RCTs) on acupuncture in treating SCI-induced neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | The following terms were searched as subject words, keywords, free-text terms, and MeSH terms: spinal cord injuries, spinal cord injury, neuropathic pain, neuralgia, acupuncture, acupuncture therapy, electroacupuncture, warming needle moxibustion, fire needling, fire needle, and fire acupuncture. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain Neuralgia | Review |
| 36034938 | This study included all available RCTs investigating acupuncture for the treatment of neuropathic pain after SCI. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | This could be the first meta-analysis to exclusively evaluate the effect of acupuncture on SCI-induced neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Six studies were included in our analysis, and the results indicated that acupuncture has a positive effect on SCI-induced neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | To date, the number of RCTs that investigated acupuncture as a therapeutic approach for SCI-induced neuropathic pain is very small. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | However, to date, no literature review has been designed to specifically assess the efficacy of acupuncture on SCI-induced neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Our study could be the first meta-analysis to systematically assess the value of acupuncture in patients with neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Fourth, there were many differences in the injured spinal segments between the affected individuals, and thus, this made it more complicated and difficult to interpret the effects of acupuncture on SCI-induced neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | Third, the absence of ASIA grades in most studies limited our ability to analyze the effects of acupuncture on SCI-induced neuropathic pain in different ASIA grades. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36034938 | In conclusion, acupuncture may have a positive role in the management of SCI-induced neuropathic pain. | Evid Based Complement Alternat Med. 2022 Aug 19;2022:6297484. doi: 10.1155/2022/6297484. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Potential mechanisms of acupuncture for neuropathic pain based on somatosensory system | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Acupuncture has been increasingly used as an adjuvant or complementary therapy for neuropathic pain. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | This review aimed to summarize the potential mechanisms of acupuncture on neuropathic pain based on the somatosensory system, and guided for future both foundational and clinical studies. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Here, we argued that acupuncture may have the potential to inhibit neuronal activity caused by neuropathic pain, through reducing the activation of pain-related ion channels and suppressing glial cells (including microglia and astrocytes) to release inflammatory cytokines, chemokines, amongst others. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | The cumulative evidence demonstrated that acupuncture provided an alternative or adjunctive therapy for neuropathic pain. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Acupuncture as a non-invasive strategy for nerve stimulation, was a valuable therapy to improve neuropathic pain with a low incidence of adverse events. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | We searched PubMed, Web of Science, and Embase for available information describing issues related to acupuncture and neuropathic pain. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | The inclusion criteria were designed as follows: (1) Research focused on acupuncture for neuropathic pain. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Application of acupuncture for neuropathic pain | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Despite of evidence supported the effectiveness of acupuncture for neuropathic pain and showed benefits of MA and EA. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Clinical evidence for acupuncture on neuropathic pain | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Table 1 listed acupuncture treatments for neuropathic pain caused by different diseases. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | With the deepening of clinical research, the efficacy of acupuncture on neuropathic pain has been confirmed by several systemic reviews and meta-analyses, which were listed in Table 2. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Based on currently available evidences, acupuncture appears more effective than pharmacotherapy or surgery with high degree of safety for improving neuropathic pain. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Acupuncture inhibits neuropathic pain induced by various diseases. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Animal models of neuropathic pain are critical for understanding the underlying mechanism and further development of acupuncture therapy. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | A variety of neuropathic pain animal models which induced by central or peripheral nerve injury have been used to study the acupuncture mechanism (Table 3). | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Acupuncture mechanisms on neuropathic pain | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | The mechanism of acupuncture for neuropathic pain is mediated by the somatosensory system (Figure 4). | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Acupuncture mechanisms on neuropathic pain. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Acupuncture regulates ion-channel dysregulation in neuropathic pain. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Acupuncture inhibited neuronal activity caused by neuropathic pain, through reducing pain-related ion channels and receptors activation. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | In neuropathic pain, acupuncture plays a complex and critical role in the network of descending pathways projecting from brain structures to the spinal dorsal horn (Figure 7). | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Acupuncture inhibits neuropathic pain through the downstream pathway. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | However, there are no reports of neuropathic pain relief by acupuncture mediated by 5-HT2A, providing a direction for the next study. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain Pain Relief | Review |
| 36203799 | Brain processing of acupuncture stimuli in neuropathic pain patients or animals may underlie its beneficial effects. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Evidence suggested that neuropathic pain patients responded to acupuncture with more pronounced fMRI signal decrease in the amygdala and signal increase in the lateral hypothalamic area differently than healthy people. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | We speculated, in this case, acupuncture inhibited neuronal activity caused by neuropathic pain, through reducing pain-related ion channels and protein kinases activation (Figure 5). | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | As a matter of fact, the optimal prescription of acupuncture treatment (acupuncture point, degree of stimulation, frequency of treatment, and a number of treatment sessions) for neuropathic pain is a controversial issue amongst acupuncture experts. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Acupuncture has been used to treat neuropathic pain caused by different diseases. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Acupuncture was considered as a treatment option for diabetic neuropathic pain. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | However, the analgesic effect of acupuncture on neuropathic pain induced by spinal cord injury has an obvious selectivity, which depends on the location and type of pain, as well as the type of injury. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Analgesic Effect Neuropathic Pain | Review |
| 36203799 | In neuropathic pain conditions, acupuncture may improve pain through somatosensory system including both central and peripheral mechanism. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | In the periphery, acupuncture inhibited neuronal activity caused by neuropathic pain, through reducing pain-related ion channels and receptors activation (Figure 5). | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | The cumulative evidence demonstrated that acupuncture provided an alternative or adjunctive therapy for neuropathic pain. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36203799 | Conducting these studies in the future will provide better evidence to guide clinical on acupuncture modalities, acupuncture parameters and acupoints for the treatment of neuropathic pain. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Neuropathic Pain | Review |
| 36276855 | Comparison of Efficacy of Acupuncture-Related Therapy in the Treatment of Postherpetic Neuralgia: A Network Meta-Analysis of Randomized Controlled Trials | Evid Based Complement Alternat Med. 2022 Oct 14;2022:3975389. doi: 10.1155/2022/3975389. eCollection 2022. | Neuralgia | Review |
| 36276855 | Acupuncture therapy based on meridian theory is widely regarded as potentially beneficial and safe for the treatment of neuropathic pain. | Evid Based Complement Alternat Med. 2022 Oct 14;2022:3975389. doi: 10.1155/2022/3975389. eCollection 2022. | Neuropathic Pain | Review |
| 36408345 | Recent studies have shown that repeated electroacupuncture has a pronounced analgesic effect on rats with chronic neuralgia and can significantly improve their pain aversion. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Analgesic Effect Neuralgia | Review |
| 36482655 | Effects of acupuncture in the treatment of occipital neuralgia: A systematic review and meta-analysis | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Acupuncture is used to treat subjects with occipital neuralgia, which is 1 of the main causes of occipital pain; however, its effect is conflicting. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Hence, the current study aims to evaluate the effects of acupuncture in the treatment of occipital neuralgia. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | In a systematic search of PubMed, Embase, OVID, China National Knowledge Infrastructure, Cochrane Library, Chinese Biomedical Literature Database, Wanfang databases, and Google Scholar until July 2021, 15 studies aimed to evaluate the effects of acupuncture in the treatment of occipital neuralgia were included. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Acupuncture alone or acupuncture plus medication had a significantly beneficial effect on the effective rate of treatment, safety and visual analog scale compared to medication in the treatment of occipital neuralgia. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Occipital nerve blocks are performed after other headache management techniques have been unsuccessful, including acupuncture, pharmacoacupuncture, acupotomy, and chuna (tuina) therapy for occipital neuralgia. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | In addition to standard acupuncture, pharmacopuncture, fire needle acupuncture, and electroacupuncture may be utilized for the treatment of occipital neuralgia. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Case studies and randomized controlled trials are the types of research currently accessible on the effects of acupuncture on occipital neuralgia. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Acupuncture has been used to treat many cases of occipital neuralgia in Asia (China and Korea), but the results of these treatments have only been documented in a small number of published articles. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | The purpose of these studies was to analyze the effectiveness of acupuncture as a complementary treatment for occipital neuralgia | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | A protocol of search strategies was prepared according to the PICOS principle, and it was defined as follows: P (population): subjects with occipital neuralgia; I (intervention/exposure): effects of acupuncture in the treatment of occipital neuralgia; C (comparison): acupuncture compared to medication or acupuncture plus medication compared to medication in the treatment of occipital neuralgia; O (outcome): effective rate of treatment (Ratio of patients who improved completely or partially to those who did not improve was used to determine the effective rate. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | First, we conducted a systematic search of China National Knowledge Infrastructure, OVID, Chinese Biomedical Literature Database, Embase, Cochrane Library, PubMed, Wanfang databases, and Google Scholar until July 2021, by using several keywords and related words for the acupuncture, occipital neuralgia, medication, effective rate, visual analog scale, as shown in Table 1. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | In addition, the title and abstracts (for the studies which appeared as a result of the search in databases) were revised to eliminate studies that did not show any relationship to the effects of acupuncture in the treatment of occipital neuralgia. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | When the data from a particular study differed based on the assessment of the relationship of the effects of acupuncture in the treatment of occipital neuralgia, we extracted the data separately (in case we are using numbers while the included study presented the data as a percentage, authors convert the extracted data into numbers to be analyzed in the same way with other studies). | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Fifteen studies included 916 subjects with neuralgia at the start of the study; 462 of them were using acupuncture and 454 were given other medication as control. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | All studies evaluated the effects of acupuncture in the treatment of occipital neuralgia. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Forest plot of the effect of acupuncture on the effective rate of treatment in subjects with neuralgia compared to the medication group (A), acupuncture on EX B2 point (B), and acupuncture plus medication (C). | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Forest plot of the effect of acupuncture on the visual analog scale in subjects with neuralgia compared to the medication group. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Forest plot of the effect of acupuncture on the incidence of adverse events in subjects with neuralgia compared to the medication group. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Acupuncture had a beneficially lower visual analog scale, and a higher effective rate of treatment compared to medication in the treatment of occipital neuralgia according to the included studies. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | To evaluate the potential efficacy of acupuncture in people with occipital neuralgia, we conducted a systematic review and meta-analysis to carefully compile the evidence from the available research. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Acupuncture, electroacupuncture, pharmacoacupuncture, moxibustion, and chuna manual treatment are some of the procedures used to treat occipital neuralgia in China and Korea, all of which have little to no side effects. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia Side Effects | Review |
| 36482655 | Acupuncture, moxibustion, electroacupuncture, and chuna are currently used to handle large numbers of patients with occipital neuralgia by institutions in China and Korea. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | The effectiveness of acupuncture for occipital neuralgia has been studied extensively through randomized controlled studies, while the underlying mechanism is still up for debate. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Similar results were found in other meta-analyses concerning the use of acupuncture for the treatment of occipital neuralgia. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | While there are certainly plenty of doctors in the world, even though acupuncture is being successfully used by both Chinese and Korean medical professionals to treat occipital neuralgia in clinical practice, there has been so little research done on the topic that we were only able to look at studies completed in China and Korea. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Future research on acupuncture treatment for occipital neuralgia is thus required in other countries. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Research into the effectiveness of acupuncture for occipital neuralgia relied on data from other studies, which could introduce bias due to missing information. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36482655 | Acupuncture alone or acupuncture plus medication had a beneficial effect on a higher effective rate of treatment compared to medication in the treatment of occipital neuralgia according to the included studies. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia | Review |
| 36698826 | With respect to the analgesic effect of neuropathic pain, electroacupuncture might alleviate the hyperalgesia state through inhibition of prostaglandin E2 secretion after 1 week of intervention in a rat model. | Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. | Analgesic Effect Neuropathic Pain | Review |
| 36704010 | Efficacy of different acupuncture therapies on postherpetic neuralgia: A Bayesian network meta-analysis | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Neuralgia | Review |
| 36704010 | This provides a new direction for clinical treatment of PHN and, perhaps, a novel approach for treating other types of chronic neuropathic pain using acupuncture. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Neuropathic Pain | Review |
| 36704010 | (2) Sodium channels are involved in the overexcitation of sensory neurons leading to neuropathic pain, and acupuncture can change sodium ion channel expression to produce analgesic effects. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Analgesic Effect Neuropathic Pain | Review |
| 36756246 | Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect Neuropathic Pain | Review |
| 36756246 | In conclusion, the regulation of nerve signal transduction and neuroimmune crosstalk at the peripheral and central levels mediates the analgesic effects of acupuncture for neuropathic pain in an integrated manner. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect Neuropathic Pain | Review |
| 36756246 | These findings provide a reliable basis for better clinical application of acupuncture in the management of neuropathic pain. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Neuropathic Pain | Review |
| 36756246 | For the mechanism studies, design data were extracted and classified using a predefined data extraction table that specified the type of neuropathic pain model, intervention (method, acupuncture point, acupuncture parameters), and outcome measures (pain-related behaviors, mechanism indicators). | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Neuropathic Pain | Review |
| 36756246 | Animal models and intervention parameters of acupuncture for neuropathic pain | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Neuropathic Pain | Review |
| 36756246 | Animal models of acupuncture for neuropathic pain | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Neuropathic Pain | Review |
| 36756246 | Intervention parameters of acupuncture for neuropathic pain | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Neuropathic Pain | Review |
| 36756246 | Mechanism of action of acupuncture in the treatment of neuropathic pain | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Neuropathic Pain | Review |
| 36756246 | Acupuncture inhibits the upward excitatory transmission system in neuropathic pain | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Neuropathic Pain | Review |
| 36756246 | Acupuncture promotes the descending inhibitory conduction system of neuropathic pain | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Neuropathic Pain | Review |
| 36756246 | Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect Neuropathic Pain | Review |
| 36845439 | The key search terms were composed of the following group terms: (1) sciatica (sciatic neuralgia, sciatic pain, and sciatic neuropathy), (2) acupuncture (electroacupuncture, needle, needling, acupuncture and moxibustion, and warm acupuncture), and (3) sciatica plus acupuncture. | Front Neurosci. 2023 Feb 9;17:1097830. doi: 10.3389/fnins.2023.1097830. eCollection 2023. | Neuralgia | Review |
| 36845439 | Inflammatory and neuropathic pain can be relieved effectively by acupuncture. | Front Neurosci. 2023 Feb 9;17:1097830. doi: 10.3389/fnins.2023.1097830. eCollection 2023. | Neuropathic Pain | Review |
| 36950556 | The cancer pain categories treated by acupuncture were mainly breast pain, neuropathic pain, and low back pain, which were characterized by chronic pain. | Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. | Neuropathic Pain Cancer Pain | Review |
| 36950556 | We can also infer that studies on the treatment of cancer pain with acupuncture have covered a variety of types, including breast pain, arthralgia, neuropathic pain, and low back pain. | Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. | Neuropathic Pain Cancer Pain | Review |
| 36950556 | Then, other RCTs also demonstrated that acupuncture can alleviate the neuropathic pain (eg, hand numbness, tingling, and pain) of CIPN and increase touch perception thresholds. | Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. | Neuropathic Pain | Review |
| 36964825 | The study was considered eligible if it included patients with paresthesia, facial paralysis, or neuralgia, neuropathies within dentistry, and referred to the application of laser acupuncture as a treatment method. | Lasers Med Sci. 2023 Mar 25;38(1):92. doi: 10.1007/s10103-023-03754-w. | Neuralgia | Review |
| 36964825 | A study was considered eligible if it presented: paresthesia, facial paralysis, or neuralgia and studies that addressed neuropathy in dentistry and referred to the application of laser acupuncture as a possible treatment method. | Lasers Med Sci. 2023 Mar 25;38(1):92. doi: 10.1007/s10103-023-03754-w. | Neuralgia | Review |
| 36964825 | The study was excluded when the focus did not correspond to the proposed question, did not present laser acupuncture as a clinical intervention, presented neuropathies and neuralgias, but did not apply to the dental surgeon, and was structured as reviews, editorials, letters, case reports, or in cases of duplicate results. | Lasers Med Sci. 2023 Mar 25;38(1):92. doi: 10.1007/s10103-023-03754-w. | Neuralgia | Review |
| 36964825 | A new selection was made by reading the full text, and according to the inclusion and exclusion criteria, 21 studies were excluded because they did not use laser acupuncture as a clinical intervention, and 43 studies included neuropathies and neuralgias, but unrelated to dentistry. | Lasers Med Sci. 2023 Mar 25;38(1):92. doi: 10.1007/s10103-023-03754-w. | Neuralgia | Review |
| 36964825 | Despite there are some studies in the literature on the therapeutic effects of traditional acupuncture and local laser therapy on neuropathic pain, such as trigeminal neuralgia, no studies have specifically associated the use of low-power lasers with acupoints to modulate this clinical condition. | Lasers Med Sci. 2023 Mar 25;38(1):92. doi: 10.1007/s10103-023-03754-w. | Neuropathic Pain Neuralgia | Review |
| 36964825 | Therefore, it is important to perform randomized clinical trials that evaluate the intervention of laser acupuncture in facial neuralgia, as there are studies showing a positive association between pain control and the application of laser in acupoints. | Lasers Med Sci. 2023 Mar 25;38(1):92. doi: 10.1007/s10103-023-03754-w. | Neuralgia | Review |
| 36964825 | Future studies investigating the effects of laser acupuncture treatment on neuropathic facial pain, such as trigeminal neuralgia, are also encouraged, as no such studies were found in the literature to be included in this review. | Lasers Med Sci. 2023 Mar 25;38(1):92. doi: 10.1007/s10103-023-03754-w. | Neuralgia | Review |
| 37525791 | Recommendation 1.8 states that acupuncture can be used for chemotherapy-induced peripheral neuropathy based on a study involving 75 patients, where true acupuncture demonstrated a significant reduction in neuropathic pain. | Cureus. 2023 Jun 30;15(6):e41203. doi: 10.7759/cureus.41203. eCollection 2023 Jun. | Neuropathic Pain | Review |
| 37712096 | Brain nuclei and neural circuits in neuropathic pain and brain modulation mechanisms of acupuncture: a review on animal-based experimental research | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Neuropathic Pain | Review |
| 37712096 | Acupuncture modulates neurotransmitters and receptors in the treatment of neuropathic pain | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Neuropathic Pain | Review |
| 37712096 | In addition to the analgesic effects, acupuncture may improve neuropathic pain-induced mood/cognitive dysfunction by restoring overall DNA methylation in the PFC. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect Neuropathic Pain Cognitive Function Mood | Review |
| 37773829 | A total of 26 RCTs involving 1929 HZ patients were included, and the network meta-analysis results showed that acupotomy appeared to be most effective in terms of improving VAS scores and the time of incrustation; SUCRA cumulative probability ranking showed the best efficacy of bloodletting in improving efficiency and the time of ceasing new blisters, acupuncture in improving the time of decrustation, and moxibustion in reducing the incidence of postherpetic neuralgia (PHN). | Medicine (Baltimore). 2023 Sep 29;102(39):e34920. doi: 10.1097/MD.0000000000034920. | Neuralgia | Review |
| 37780709 | Thus, acupuncture inhibits neuropathic pain by suppressing BDNF levels. | Front Neurol. 2023 Sep 14;14:1248348. doi: 10.3389/fneur.2023.1248348. eCollection 2023. | Neuropathic Pain | Review |
| 37941605 | According to the experimental results, electroacupuncture can upregulate β-endorphin expression, which reduces neuropathic pain and aid in the healing of damaged brachial plexus nerves. | Front Cell Neurosci. 2023 Oct 24;17:1253438. doi: 10.3389/fncel.2023.1253438. eCollection 2023. | Neuropathic Pain | Review |
| 38046583 | A study has even found that the effects of standard high-frequency neurostimulation may be worse than acupuncture or other types of electrical stimulation, and acupuncture can become a promising treatment method for patients with drug-resistant neuropathic pain. | Front Neurol. 2023 Nov 17;14:1268626. doi: 10.3389/fneur.2023.1268626. eCollection 2023. | Neuropathic Pain | Review |
| 38046594 | Acupuncture also has great advantages in treating neuropathic pain. | Front Neurol. 2023 Nov 16;14:1281485. doi: 10.3389/fneur.2023.1281485. eCollection 2023. | Neuropathic Pain | Review |
| 38046594 | Numerous animal experiments and clinical studies suggest that acupuncture primarily intervenes in neuropathic pain through the sensory, emotional, cognitive, and social dimensions. | Front Neurol. 2023 Nov 16;14:1281485. doi: 10.3389/fneur.2023.1281485. eCollection 2023. | Neuropathic Pain Mood | Review |
| 38046594 | A meta-analysis of acupuncture for neuropathic pain suggested that the adverse effects of acupuncture for neuropathic pain were mild and reversible. | Front Neurol. 2023 Nov 16;14:1281485. doi: 10.3389/fneur.2023.1281485. eCollection 2023. | Neuropathic Pain Adverse Reactions | Review |
| 35647012 | The analgesic effects of EA are mainly manifested as alleviation of diabetic neuropathic pain, postherpetic neuralgia, tactile sensation-induced pain, paclitaxel chemotherapy pain, reduction of cold and heat sensitive pain threshold, and other various types of pain. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Analgesic Effect Neuropathic Pain Neuralgia | Clinic |
| 36749304 | The EA's analgesic effect on neuropathic pain may rely on the activation the brain functional connectivity between bilateral hemispheres and the sensorimotor cortex (Hou etxc2xa0al.,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Analgesic Effect Neuropathic Pain | Clinic |
| 36749304 | Studies no various diseases such as heroin addicts (Luo etxc2xa0al.,), trigeminal neuralgia(Ge etxc2xa0al.,), migraine (Chen etxc2xa0al.,), cervical discogenic pain (Ma etxc2xa0al.,), chronic low back pain(Zhang etxc2xa0al.,), fibromyalgia (Katherine etxc2xa0al.,), suggest that ALFF, as a reliable indicator of regional spontaneous neural activity in restingxe2x80x90state, can be widely used in pain disease studies. | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Neuralgia | Clinic |
| 20654703 | Electroacupuncture versus celecoxib for neuropathic pain in rat SNL model. | Neuroscience. 2010 Oct 13;170(2):655-61. doi: 10.1016/j.neuroscience.2010.07.031. Epub 2010 Jul 25. | Neuropathic Pain | Mechanism |
| 20654703 | Our recent study has shown that it may inhibit cyclooxygenase-2 (COX-2) in the spinal dorsal horn where COX-2 is upregulated after the development of neuropathic pain following spinal nerve ligation (SNL). | Neuroscience. 2010 Oct 13;170(2):655-61. doi: 10.1016/j.neuroscience.2010.07.031. Epub 2010 Jul 25. | Neuropathic Pain | Mechanism |
| 20654703 | Paw-withdrawal-threshold to mechanical stimulation and paw-withdrawal-latency to thermal test were tested for neuropathic pain at four intervals following the treatments in comparison with the pre-treatment and non-treatment controls. | Neuroscience. 2010 Oct 13;170(2):655-61. doi: 10.1016/j.neuroscience.2010.07.031. Epub 2010 Jul 25. | Neuropathic Pain | Mechanism |
| 15336634 | Acupoint stimulation with diluted bee venom (apipuncture) alleviates thermal hyperalgesia in a rodent neuropathic pain model: involvement of spinal alpha 2-adrenoceptors. | J Pain. 2004 Aug;5(6):297-303. doi: 10.1016/j.jpain.2004.05.003. | Neuropathic Pain | Mechanism |
| 15336634 | In the present study we investigated the potential antihyperalgesic and antiallodynic effects of apipuncture in a rat neuropathic pain model. | J Pain. 2004 Aug;5(6):297-303. doi: 10.1016/j.jpain.2004.05.003. | Neuropathic Pain | Mechanism |
| 15336634 | PERSPECTIVE: The antinociceptive effect of apipuncture was evaluated in a rodent neuropathic pain model. | J Pain. 2004 Aug;5(6):297-303. doi: 10.1016/j.jpain.2004.05.003. | Neuropathic Pain | Mechanism |
| 20138846 | This study was performed to determine whether spinal GABAergic systems mediate the relieving effects of low frequency electroacupuncture (EA) on cold allodynia in a rat tail model of neuropathic pain. | Brain Res. 2010 Mar 31;1322:24-9. doi: 10.1016/j.brainres.2010.02.001. Epub 2010 Feb 6. | Neuropathic Pain | Mechanism |
| 12297003 | cDNA microarray analysis of the differential gene expression in the neuropathic pain and electroacupuncture treatment models. | J Biochem Mol Biol. 2002 Jul 31;35(4):420-7. doi: 10.5483/bmbrep.2002.35.4.420. | Neuropathic Pain | Mechanism |
| 12297003 | Partial nerve injury is the main cause of neuropathic pain disorders in humans. | J Biochem Mol Biol. 2002 Jul 31;35(4):420-7. doi: 10.5483/bmbrep.2002.35.4.420. | Neuropathic Pain | Mechanism |
| 12297003 | Although the mechanism of neuropathic pain and analgesic effects of electroacupuncture (EA) have been studied in a rat model system, its detailed mechanism at the molecular level remains unclear. | J Biochem Mol Biol. 2002 Jul 31;35(4):420-7. doi: 10.5483/bmbrep.2002.35.4.420. | Analgesic Effect Neuropathic Pain | Mechanism |
| 12297003 | Messenger RNAs that were pooled from the spinal nerves of 7 normal, 7 neuropathic pain, and 7 EA treatment rat models were compared. | J Biochem Mol Biol. 2002 Jul 31;35(4):420-7. doi: 10.5483/bmbrep.2002.35.4.420. | Neuropathic Pain | Mechanism |
| 12297003 | This indicates that opioid-signaling events are involved in neuropathic pain and the analgesic effects of EA. | J Biochem Mol Biol. 2002 Jul 31;35(4):420-7. doi: 10.5483/bmbrep.2002.35.4.420. | Analgesic Effect Neuropathic Pain | Mechanism |
| 12297003 | The potential application of these data include the identification and characterization of signaling pathways that are involved in the EA treatment, studies on the role of the opioid receptor in neuropathic pain, and further exploration on the role of selected identified genes in animal models. | J Biochem Mol Biol. 2002 Jul 31;35(4):420-7. doi: 10.5483/bmbrep.2002.35.4.420. | Neuropathic Pain | Mechanism |
| 25074385 | Electroacupuncture inhibits excessive interferon-gamma evoked up-regulation of P2X4 receptor in spinal microglia in a CCI rat model for neuropathic pain. | Br J Anaesth. 2015 Jan;114(1):150-7. doi: 10.1093/bja/aeu199. Epub 2014 Jul 29. | Neuropathic Pain | Mechanism |
| 25074385 | BACKGROUND: Although electroacupuncture (EA) is effective in the relief of neuropathic pain, the underlying mechanisms remain unclear. | Br J Anaesth. 2015 Jan;114(1):150-7. doi: 10.1093/bja/aeu199. Epub 2014 Jul 29. | Neuropathic Pain | Mechanism |
| 25074385 | Since excessive release of interferon-gamma (IFN-gamma) after nerve injury transforms quiescent spinal microglia into an activated state with more neuropathic pain, associated with purinergic receptor P2X4 expression, it is possible that EA may mediate its analgesic effect by attenuating IFN-gamma release and subsequent generation of P2X4R(+) microglia. | Br J Anaesth. 2015 Jan;114(1):150-7. doi: 10.1093/bja/aeu199. Epub 2014 Jul 29. | Analgesic Effect Neuropathic Pain | Mechanism |
| 11849761 | Effects of electroacupuncture on the mechanical allodynia in the rat model of neuropathic pain. | Neurosci Lett. 2002 Mar 1;320(1-2):49-52. doi: 10.1016/s0304-3940(02)00027-7. | Neuropathic Pain | Mechanism |
| 11849761 | The analgesic effects of acupuncture on the mechanical allodynia in the rat model of neuropathic pain have not yet been studied. | Neurosci Lett. 2002 Mar 1;320(1-2):49-52. doi: 10.1016/s0304-3940(02)00027-7. | Analgesic Effect Neuropathic Pain | Mechanism |
| 11849761 | To produce neuropathic pain, the right superior caudal trunk was resected between the S3 and S4 spinal nerves. | Neurosci Lett. 2002 Mar 1;320(1-2):49-52. doi: 10.1016/s0304-3940(02)00027-7. | Neuropathic Pain | Mechanism |
| 19010737 | Acupoint stimulation with diluted bee venom (apipuncture) potentiates the analgesic effect of intrathecal clonidine in the rodent formalin test and in a neuropathic pain model. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect Neuropathic Pain | Mechanism |
| 19010737 | In a rat neuropathic pain model i.t. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Neuropathic Pain | Mechanism |
| 22269805 | Analgesic effect of electroacupuncture on chronic neuropathic pain mediated by P2X3 receptors in rat dorsal root ganglion neurons. | Neurochem Int. 2012 Mar;60(4):379-86. doi: 10.1016/j.neuint.2012.01.006. Epub 2012 Jan 18. | Analgesic Effect Neuropathic Pain | Mechanism |
| 22269805 | Adenosine 5'-triphosphate disodium (ATP) gated P2X receptors, especially the subtype P2X(3), play a key role in transmission of pain signals in neuropathic pain, ATP has been documented to play a significant role in the progression of pain signals, suggesting that control of these pathways through electroacupuncture (EA) is potentially an effective treatment for chronic neuropathic pain. | Neurochem Int. 2012 Mar;60(4):379-86. doi: 10.1016/j.neuint.2012.01.006. Epub 2012 Jan 18. | Neuropathic Pain | Mechanism |
| 22269805 | To determine the significance of EA on neuropathic pain mediated by P2X(3) receptors in the dorsal root ganglion (DRG) neurons, mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were recorded, and the expression of P2X(3) receptors in the DRG neurons was assessed by immunohistochemistry (IHC) and in situ hybridization (ISH). | Neurochem Int. 2012 Mar;60(4):379-86. doi: 10.1016/j.neuint.2012.01.006. Epub 2012 Jan 18. | Immunity Neuropathic Pain | Mechanism |
| 35138669 | Electroacupuncture relieves neuropathic pain by inhibiting degradation of the ecto-nucleotidase PAP in the dorsal root ganglions of CCI mice. | Eur J Pain. 2022 May;26(5):991-1005. doi: 10.1002/ejp.1923. Epub 2022 Feb 17. | Neuropathic Pain | Mechanism |
| 35100811 | Electroacupuncture suppresses spinal nerve ligation-induced neuropathic pain via regulation of synaptic plasticity through upregulation of basic fibroblast growth factor expression. | Acupunct Med. 2022 Aug;40(4):379-388. doi: 10.1177/09645284211066499. Epub 2022 Feb 1. | Neuropathic Pain | Mechanism |
| 35100811 | BACKGROUND: Improving synaptic plasticity is a good way to alleviate neuropathic pain. | Acupunct Med. 2022 Aug;40(4):379-388. doi: 10.1177/09645284211066499. Epub 2022 Feb 1. | Neuropathic Pain | Mechanism |
| 35100811 | CONCLUSION: These findings indicate that EA suppresses SNL-induced neuropathic pain by improving synaptic plasticity via upregulation of bFGF expression. | Acupunct Med. 2022 Aug;40(4):379-388. doi: 10.1177/09645284211066499. Epub 2022 Feb 1. | Neuropathic Pain | Mechanism |
| 29436370 | Isoflurane and the Analgesic Effect of Acupuncture and Electroacupuncture in an Animal Model of Neuropathic Pain. | J Acupunct Meridian Stud. 2018 Jun;11(3):97-106. doi: 10.1016/j.jams.2018.01.004. Epub 2018 Feb 6. | Analgesic Effect Neuropathic Pain | Mechanism |
| 29436370 | The present study aimed to determine whether isoflurane interferes with the analgesic effects of acupuncture (Ac) and electroacupuncture (EA), using a neuropathic pain (NP) rat model. | J Acupunct Meridian Stud. 2018 Jun;11(3):97-106. doi: 10.1016/j.jams.2018.01.004. Epub 2018 Feb 6. | Analgesic Effect Neuropathic Pain | Mechanism |
| 27707699 | Effect of transcutaneous electrical acupuncture point stimulation at different frequencies in a rat model of neuropathic pain. | Acupunct Med. 2017 Apr;35(2):142-147. doi: 10.1136/acupmed-2016-011063. Epub 2016 Oct 4. | Neuropathic Pain | Mechanism |
| 27707699 | In the present study, we investigated the effect of transcutaneous electrical acupuncture point stimulation (TEAS) at different frequencies in a chronic constriction injury (CCI) model of neuropathic pain in rats. | Acupunct Med. 2017 Apr;35(2):142-147. doi: 10.1136/acupmed-2016-011063. Epub 2016 Oct 4. | Neuropathic Pain | Mechanism |
| 27707699 | METHODS: CCI was induced by ligating the common sciatic nerve, which produced neuropathic pain. | Acupunct Med. 2017 Apr;35(2):142-147. doi: 10.1136/acupmed-2016-011063. Epub 2016 Oct 4. | Neuropathic Pain | Mechanism |
| 27707699 | CONCLUSIONS: The use of low frequency TEAS significantly mitigated neuropathic pain in this rat model, and its analgesic effect is likely mediated by upregulation of MOR expression in the DRG. | Acupunct Med. 2017 Apr;35(2):142-147. doi: 10.1136/acupmed-2016-011063. Epub 2016 Oct 4. | Analgesic Effect Neuropathic Pain | Mechanism |
| 19607689 | Generally, of the three types of somatic, visceral and neuropathic cancer pain conditions, neuropathic pain is the most predominant in cancer patients due to compression or infiltration of peripheral nerves by malignant tumors. | J Exp Clin Cancer Res. 2009 Jul 16;28(1):102. doi: 10.1186/1756-9966-28-102. | Neuropathic Pain Cancer Pain | Mechanism |
| 19607689 | Neuropathic pain resulting from nerve injury is characterized by spontaneous pain, allodynia (the perception of normally innocuous stimuli as painful) and hyperalgesia (an increased sensitivity to painful stimuli). | J Exp Clin Cancer Res. 2009 Jul 16;28(1):102. doi: 10.1186/1756-9966-28-102. | Neuropathic Pain | Mechanism |
| 19607689 | 4A, substance P was overexpressed in the tumor control group compared to that of the normal control, suggesting that the tumor mass could activate neuropathic pain-related proteins. | J Exp Clin Cancer Res. 2009 Jul 16;28(1):102. doi: 10.1186/1756-9966-28-102. | Neuropathic Pain | Mechanism |
| 19607689 | Ten days after inoculation, the tumor mass was shown to surround half the area around the sciatic nerve while 24 days after inoculation, the S-180 tumor cells embedded most of the gluteal area, inducing neuropathic pain by compression of the sciatic nerve. | J Exp Clin Cancer Res. 2009 Jul 16;28(1):102. doi: 10.1186/1756-9966-28-102. | Neuropathic Pain | Mechanism |
| 37548586 | Previous studies have found that reducing or inhibiting BDNF expression reduces neuropathic pain (Khan et al.,). | Brain Behav. 2023 Oct;13(10):e3177. doi: 10.1002/brb3.3177. Epub 2023 Aug 7. | Neuropathic Pain | Mechanism |
| 37548586 | The pain in the surgical opening is acute and can develop into neuropathic pain. | Brain Behav. 2023 Oct;13(10):e3177. doi: 10.1002/brb3.3177. Epub 2023 Aug 7. | Neuropathic Pain | Mechanism |
| 30883553 | Previous studies reported LA stimulating the acupoints ST36 (Zu San Li) and TH5 (Waiguan) was effective in reducing edema and acute inflammatory pain in AIA rats and spontaneous pain and thermal hyperalgesia in neuropathic pain rats. | PLoS One. 2019 Mar 18;14(3):e0211341. doi: 10.1371/journal.pone.0211341. eCollection 2019. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 32796318 | Acupuncture alleviates chronic pain and comorbid conditions in a mouse model of neuropathic pain: the involvement of DNA methylation in the prefrontal cortex | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Acupuncture treatment for 6-month period altered DNA methylation patterns, particularly in the prefrontal cortex, in a mouse model of chronic neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | We examined whether acupuncture can restore epigenetic changes caused by chronic pain, and identified the underlying mechanisms in neuropathic pain mice. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Acupuncture treatment for 6 months (3 days/week) improved mechanical/cold allodynia and the emotional/cognitive dysfunction caused by left partial sciatic nerve ligation (PSNL)-induced neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Cognitive Function Mood | Mechanism |
| 32796318 | Chronic neuropathic pain results from pathological adaptations in the CNS associated with brain structure and connectivity alterations in the prefrontal cortex (PFC), hippocampus (HIP), amygdala (AMG), hypothalamus, and periaqueductal gray matter (PAG). | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Mouse studies indicate that neuropathic pain is accompanied by comorbidity that persists for several months after injury, and decreased global DNA methylation has been detected in the PFC of mice in neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Neuropathic pain model | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | These acupoints have been used for the treatment of lumbar neuropathic pain in clinical studies. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | The combination of those acupoints has been used to treat neuropathic pain such as sciatica, which includes aching and sharp pain components that radiate from the buttock downward along the course of the sciatic nerve. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | applied 3 days/week for 6 months on mechanical hyperalgesia and cold allodynia were investigated using the von Frey (B) and cold (acetone) (C) tests in a partial sciatic nerve ligation (PSNL)-induced neuropathic pain model. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | The effects of treatments with acupuncture (AP or CP) and amitriptyline in the PSNL-induced neuropathic pain model were investigated for 6 months (0 day, 1 week, 2 weeks, and 1-6 months). | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Acupuncture improved persistent mechanical hyperalgesia and cold allodynia in partial sciatic nerve ligation-induced neuropathic pain | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | The antimechanical and anticold allodynic effects of acupuncture were measured using the von Frey and acetone tests in a PSNL-induced neuropathic pain model. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | This study evaluated the antidepressant effects of acupuncture (AP or CP) and amitriptyline (PC) on depression-like behaviors generated in a PSNL neuropathic pain model using the TST. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Depression | Mechanism |
| 32796318 | treatment on cognitive impairment were examined using the Y-maze (A and B) and NOR (C and D) tests in a PSNL-induced neuropathic pain model; n = 22/group. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | The effects of acupuncture (AP or CP; 3 days/week) for 6 months on DNA methylation in various brain areas in the PSNL-induced neuropathic pain model were examined. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Next, to confirm the changes in DNMT enzymes associated with acupuncture treatment (3 days/week for 6 months) for PSNL-induced neuropathic pain, DNMT1, DNMT3a, and DNMT3b were examined by Western blot analysis in the PFC tissues of the mouse model. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Chronic neuropathic pain has multidimensional aspect from nociception to comorbid emotional and cognitive discomfort. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Mood | Mechanism |
| 32796318 | Epigenetic mechanisms are involved in various comorbid conditions in neuropathic pain, and acupuncture is efficacious in such conditions. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | However, the role of DNA methylation in the context of acupuncture and neuropathic pain is not clear. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Our results indicate that acupuncture improved nociceptive and emotional and cognitive impairment associated with PSNL-induced neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Mood | Mechanism |
| 32796318 | These results demonstrate the effect of acupuncture on DNA methylation in mediating the sensory, emotional, and cognitive impact of chronic neuropathic pain, and suggested molecular mechanism in the PFC. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Mood | Mechanism |
| 32796318 | The central sensitization induced by peripheral nerve injury contributes to neuropathic pain, and has a pernicious effect on affective processing and cognitive function in both patients and animal models. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Cognitive Function | Mechanism |
| 32796318 | Furthermore, reduction of gray matter in the PFC was associated with the appearance of emotional dysfunction in persistent neuropathic pain rats. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Mood | Mechanism |
| 32796318 | We showed that in the genome-wide methylation patterns in the PFC associated with neuropathic pain and acupuncture, the top 5 GO terms were DNA metabolic process, chromosomal part, chromatin binding, methylation, and C-5 methylation of cytosine using GO analysis, and the top 5 KEGG pathways were metabolic pathways, PI3K-Akt signaling pathway, MAPK kinase signaling pathway, Ras signaling pathway, and microRNAs in cancer. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Various types of neuropathic pain induce a reduction in metabolic activity and lead to metabolic imbalances such as mitochondrial dysfunction in DRG neurons. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Thus, we suggest that neuropathic pain increases DNA methylation in Mecp2, Dnmt1, and Dnmt3a in the PFC, which contributes to reduction in global DNA methylation in PFC and induces various abnormal behaviors, which are restored by acupuncture. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Thus, we suggest that acupuncture may improve the pain symptoms induced through increase in Ras pathway- and mitochondrial function-related genes by reducing DNA methylation in PFC of neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | However, the role of Ras pathway and mitochondrial function in the PFC of neuropathic pain is still unknown, and further research is needed. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | First, the causal relationship between DNA methylation changes in the brain and comorbidity with neuropathic pain or the effect of acupuncture was not defined. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Future studies should establish the causal relationship by inhibiting the effects of acupuncture on DNA methylation in neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Our results are consistent with the hypothesis that acupuncture alters the extent of DNA methylation induced by neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Our results also indicate that modulation of DNA methylation- and mitochondrial dysfunction-related genes may play a key role in the acupuncture-induced reversal of physiological function impairment caused by persistent neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 32796318 | Our findings enhance the molecular understanding of neuropathic pain, and may facilitate the discovery of new mechanisms of action in acupuncture treatment. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain | Mechanism |
| 34564665 | For this reason, BV acupuncture was widely used for the treatment of clinical disorders such as neuropathic pain, intervertebral disc disease, spinal cord injury, musculoskeletal pain, and arthritis in traditional Korean medicine. | Toxins (Basel). 2021 Sep 16;13(9):661. doi: 10.3390/toxins13090661. | Neuropathic Pain | Mechanism |
| 25481535 | Therefore it is worth searching for potential therapeutic options for the management of oxaliplatin-induced neuropathic pain and revealing their action mechanisms. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Neuropathic Pain | Mechanism |
| 25481535 | Several animal studies have demonstrated that the analgesic effects of BVA are mediated mainly by activation of α2-adrenergic and/or serotonergic receptors in various pain models, such as nerve injury-induced neuropathic pain, acetic acid-induced visceral pain and inflammatory pain. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Analgesic Effect Visceral Pain Neuropathic Pain Inflammatory Pain | Mechanism |
| 25481535 | There are few researches showing the effective treatment for the established neuropathic pain induced by oxaliplatin. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Neuropathic Pain | Mechanism |
| 25481535 | The potential therapeutic options are thus critically needed to manage this neuropathic pain for helping the patients overcome cancer and improving their quality of life. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Neuropathic Pain | Mechanism |
| 25481535 | Therefore, the neurochemical mechanism of the BVA effect on oxaliplatin-induced neuropathic pain still remains unclear. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Neuropathic Pain | Mechanism |
| 26184310 | Repetitive Treatment with Diluted Bee Venom Attenuates the Induction of Below-Level Neuropathic Pain Behaviors in a Rat Spinal Cord Injury Model | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | The present study was designed to examine the potential anti-nociceptive effect of repetitive DBV treatment in the development of below-level neuropathic pain in spinal cord injury (SCI) rats. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | These results indicate that the repetitive application of DBV during the induction phase not only decreased neuropathic pain behavior and glia expression, but also enhanced locomotor functional recovery after SCI. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain Motor Function | Mechanism |
| 26184310 | In particular, we showed that a single injection of DBV (0.25 mg/kg) into ST36 temporarily alleviated thermal hyperalgesia and that repetitive stimulation using DBV significantly alleviated neuropathic pain-induced mechanical and cold allodynia in a sciatic nerve chronic constrictive injury (CCI) model of rats. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | However, the precise roles of repetitive DBV treatment in the induction and maintenance phases of central neuropathic pain have not been examined. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | Especially, below-level pain after SCI represents a clinically-significant symptom of central neuropathic pain that is very difficult to treat effectively. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | Recently, a number of studies have reported the potential role of spinal astrocytes and microglia in both postoperative pain and neuropathic pain. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | Moreover, intrathecal treatment with glia inhibitors, such as minocycline (a microglia inhibitor) and propentofylline (a glia modulating agent), reduced below-level neuropathic pain behaviors in SCI rats. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | However, although there is some evidence that glial cells are activated during the development of SCI-induced neuropathic pain, the precise mechanisms underlying glial activation, particularly in lumbar segments distant from the spinal cord injury site, are poorly understood. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | Repetitive saline injection during the induction phase significantly increased GFAP expression in the spinal dorsal horn compared with that of normal animals (** p < 0.01), and repetitive DBV treatment at ST36 suppressed SCI-enhanced GFAP expression (# p < 0.05), suggesting that DBV treatment has a potent anti-nociceptive effect on SCI-induced central neuropathic pain. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | This study demonstrated that repetitive injections of DBV into the Joksamli acupuncture point during the induction phase (one to five days after SCI) of below-level neuropathic pain significantly produce a more potent and prolonged anti-nociceptive effect compared to repetitive DBV treatment during the maintenance phase (15 to 20 days after SCI) or repetitive injections of the vehicle. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | Our results demonstrate that repetitive injections of DBV into the acupuncture point play an important role during early induction, but not during maintenance of pain behaviors associated with central neuropathic pain conditions. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | However, it might be important to detect situations where the possibility for the development of below-level neuropathic pain is high, and the ability to alter this situation would be of considerable clinical value. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | Although predicting which patients suffering from SCI will go on to develop chronic central neuropathic pain is impossible, our results demonstrate that a critical time window exists in which early treatment with DBV would be effective. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | Collectively, these findings, including the present results, imply that repetitive DBV acupuncture therapy during the induction phase is able to produce a powerful analgesic effect on chronic central neuropathic pain and suggest the clinical use of repetitive DBV treatment as a potential novel strategy in the early management of SCI-induced neuropathic pain. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Analgesic Effect Neuropathic Pain | Mechanism |
| 26184310 | Recently, several studies demonstrated the involvement of glia activation in chronic pain conditions, including inflammatory pain, peripheral and central neuropathic pain. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 26184310 | Moreover, the blockade of astrocyte gap junctions by the intrathecal injection of carbenoxolone during the induction period of SCI-induced neuropathic pain reduced the development of below-level mechanical allodynia and thermal hyperalgesia and suppressed astrocytic activation in spinal cord. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | Thus, unsurprisingly, astrocyte activation may contribute to the induction of central neuropathic pain in SCI rats. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | This result indicates that glia activation in the ipsilateral lumbar spinal dorsal horn could be caused by the damage in a spinal cord injured segment (T13) and that the mechanism underlying this remote activation of glia could ultimately lead to the development of below-level neuropathic pain. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | Thus, these findings suggest that the early activation of astrocytes and microglia can initiate the induction of below-level neuropathic pain. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 26184310 | These results suggest that the repetitive application of DBV acupuncture therapy suppressed SCI-induced central neuropathic pain syndrome development and might be a potential clinical therapy for the management of SCI. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Neuropathic Pain | Mechanism |
| 25158599 | NK cells mediate the cumulative analgesic effect of electroacupuncture in a rat model of neuropathic pain | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25158599 | The present study was designed to determine the changes of immunogenic responses at different time-points of electroacupuncture (EA) interventions in neuropathic pain rats. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Immunity Neuropathic Pain | Mechanism |
| 25158599 | The neuropathic pain model was established by ligature of the left sciatic nerve to induce chronic constriction injury (CCI). | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Neuropathic Pain | Mechanism |
| 25158599 | Repeated EA interventions have a time-dependent cumulative analgesic effect in neuropathic pain rats, which is closely associated with its regulatory effects on NK cells, splenic IL-2, β-EP, and plasma IL-2, IL-1β, IFN-γ and TGF-β levels. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25158599 | Therefore, acquired immunity may also be a good biomarker for the management of clinical neuropathic pain. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Immunity Neuropathic Pain | Mechanism |
| 25158599 | Experimental studies have shown that acupuncture intervention effectively relieves chronic neuropathic pain and inflammatory pain in rats. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 25158599 | Cumulative evidence revealed that EA intervention could enhances immune function after surgical trauma or neuropathic pain in human and in animals. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Immunity Neuropathic Pain | Mechanism |
| 25158599 | In the present study, we set out to examine the change of acupuncture-associated immunoregulation under neuropathic pain conditions. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Immunity Neuropathic Pain | Mechanism |
| 25158599 | Effect of anti-asialo GM1 antibody on plasma NK cell population (A) and on EA stimulation induced reduction of PWLD in rats with neuropathic pain (B). | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Neuropathic Pain | Mechanism |
| 25158599 | Thus, changes in the profile of neurochemicals involving neuropathic pain affect the number and activity of immune cells in the plasma or spleen. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Immunity Neuropathic Pain | Mechanism |
| 25158599 | T lymphocyte may have a role in the maintenance of neuropathic pain because T-lymphocyte deficient mice were found to have a reduction in injury-induced hypersentivity but adoptive transfer reversed this effect. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Neuropathic Pain | Mechanism |
| 25158599 | At the same time, T lymphocyte that infiltrated into the central nervous system interacted with microglia and helped maintain neuropathic pain by the secretion of pro-inflammatory mediators and also possibly by facilitating the activation of astrocytes. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Neuropathic Pain | Mechanism |
| 25158599 | Moreover, some studies also suggest that modulation of T- lymphocyte phenotype might be one approach to the treatment of neuropathic pain. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Neuropathic Pain | Mechanism |
| 25158599 | Successive EA interventions have a time-dependent cumulative analgesic effect in neuropathic pain rats, which is closely associated with its regulatory effects on NK cells, splenic IL-2, β-EP, and plasma IL-2, IL-1β, IFN-γ and TGF-β levels. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25158599 | Results of the present study provide the first insight into the origins of innate to adaptive immunity following EA interventions in a rat model of neuropathic pain. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Immunity Neuropathic Pain | Mechanism |
| 24980520 | ST36 and HI4) relieves various types of pain including acute thermal, inflammatory and chronic neuropathic pain, which were known to be mediated by activation of the descending pain inhibitory system. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Neuropathic Pain | Mechanism |
| 24980520 | The similar results could be observed in the rat models of inflammatory and neuropathic pain. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Neuropathic Pain | Mechanism |
| 24980520 | The analgesic effects of EA also show marked individual differences in acute, inflammatory and neuropathic pain rats. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect Neuropathic Pain | Mechanism |
| 24980520 | Although there has been little research on the role of AMPK in nociception, very recent studies demonstrated that AMPK activation significantly alleviates acute, inflammatory and neuropathic pain through the modulation of mammalian target of rapamycin (mTOR) and mitogen activated protein kinase (MAPK) signaling in the periphery and spinal cord that are related to pain hypersensitivity. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Neuropathic Pain | Mechanism |
| 24980520 | Also, it would be interesting to examine the analgesic effects of EA on pathological pain, such as neuropathic pain, the mechanism of which is somewhat different from acute pain (e.g. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect Neuropathic Pain | Mechanism |
| 24980520 | Although the individual differences in the sensitivity of acute nociceptive and chronic neuropathic pain to EA in rats were known to be maintained, we believe that studies using pathological pain models could provide a better understanding of EA-induced analgesia and its responsiveness. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Neuropathic Pain | Mechanism |
| 29981376 | In pre-clinical studies, stimulation of ST36 suppresses neuropathic pain induced by paclitaxel, oxaliplatin, inferior caudal trunk injury, and spinal nerve ligation, as well as inflammatory pain induced by Complete Freund's Adjuvant, collagenase, and carrageenan, and visceral pain induced by acetic acid. | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Visceral Pain Neuropathic Pain Inflammatory Pain | Mechanism |
| 19756387 | The expression and functional properties of voltage-gated Na+ channels in peripheral sensory neurons can be dynamically regulated following axonal injury or peripheral inflammation, suggesting that specific voltage-gated Na+ channels may play crucial roles in inflammatory, and possibly neuropathic pain. | Cell Mol Life Sci. 2009 Nov;66(21):3505-16. doi: 10.1007/s00018-009-0136-x. | Neuropathic Pain | Mechanism |
| 21872220 | In a five-patient pilot study the modality also improved the symptoms of chemotherapy-induced neuropathic pain. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 21872220 | Thus, EA significantly inhibits paclitaxel-induced allodynia/hyperalgesia through spinal opioid receptors, and EA may be a useful complementary treatment for neuropathic pain patients. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 21872220 | Animal studies have also shown that electroacupuncture (EA) inhibits hyperalgesia in traumatic nerve injury-induced neuropathic pain animal models. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 21872220 | Recent chronic pain acupuncture/EA studies, including our own, have shown that EA produces anti-hyperalgesia in inflammatory and traumatic nerve injury-induced neuropathic pain animal models. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 21872220 | We hypothesized that spinal opioid receptors are involved differently in EA action on paclitaxel-evoked peripheral neuropathy than in inflammatory pain and traumatic nerve injury-induced neuropathic pain. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 21872220 | The present study demonstrates that 10 Hz EA produces a more potent inhibitory effect than does 100 Hz EA in a paclitaxel-induced neuropathic pain rat model. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 21872220 | Similarly, in a previous study, 2 Hz EA induced robust and longer lasting inhibition of mechanical allodynia compared to 100 Hz EA in a caudal trunk nerve injury-induced neuropathic pain model. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 21872220 | It was also found that 2 Hz EA had greater and more prolonged effects on mechanical allodynia and thermal hyperalgesia than did 100 Hz EA in a nerve injury-induced neuropathic pain rat model. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 21872220 | Taken together, these studies show that acupuncture may be useful in the management of neuropathic pain. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 21872220 | It has also been demonstrated that μ and δ but not κ receptors were involved in EA anti-hyperalgesia in a capsaicin-induced inflammatory pain model and that EA also inhibited pain through the μ and δ receptors in a caudal trunk injury-induced neuropathic pain model. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 21872220 | In addition, as demonstrated in previous studies, opioid receptors are down-regulated in the spinal cord and dorsal root ganglia in a couple of neuropathic pain animal models. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 21872220 | In summary, our experiments show that EA significantly inhibits chemotherapy-induced neuropathic pain through three subtypes of spinal opioid receptors. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 21872220 | The results support that EA may be a useful complementary treatment for neuropathic pain patients. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Neuropathic Pain | Mechanism |
| 29034548 | Paclitaxel causes neuropathic pain in cancer patients. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Neuropathic Pain | Mechanism |
| 29034548 | Basic study demonstrated that electroacupuncture (EA) significantly inhibits mechanical allodynia and hyperalgesia in nerve injury-induced neuropathic pain rat models. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Neuropathic Pain | Mechanism |
| 29034548 | In this study, we used an established rat model, paclitaxel-induced neuropathic pain, to study EA efficacy on such pain. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Neuropathic Pain | Mechanism |
| 29034548 | As aforementioned in introduction, it is not known whether 5-HT1A receptors are involved in EA inhibition of neuropathic pain. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Neuropathic Pain | Mechanism |
| 29034548 | It has been reported that 30% patients with neuropathy have turned to acupuncture due to inadequate control of neuropathic pain. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Neuropathic Pain | Mechanism |
| 29034548 | 5-HT1A receptor agonist attenuated mechanical allodynia in a rat model of trigeminal neuropathic pain, and inhibited formalin-induced Fos expression, nociceptive pinch-evoked responses, nociceptive neuron wind-up and C-fiber-mediated late responses. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Neuropathic Pain | Mechanism |
| 29034548 | The data suggest that inhibition of p-CaMKII may lead to alleviation of neuropathic pain. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Neuropathic Pain | Mechanism |
| 29034548 | Taken together, our data suggest that EA activates 5-HT1A receptors in the spinal cord to inhibit p-CaMKII, leading to alleviation of chemotherapy-induced neuropathic pain. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Neuropathic Pain | Mechanism |
| 29034548 | Previous studies also found that EA at 2 Hz, but not 100 Hz, was effective in the treatment of spinal nerve ligation (SNL)-induced neuropathic pain. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Neuropathic Pain | Mechanism |
| 22524543 | Likewise, we found that intrathecal injection of a secretory version of human PAP (hPAP) had long-lasting (3 days), A1R-dependent antinociceptive effects in pre-clinical models of inflammatory pain and neuropathic pain. | Mol Pain. 2012 Apr 23;8:28. doi: 10.1186/1744-8069-8-28. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 22524543 | We next evaluated whether PAPupuncture could block hypersensitivity associated with inflammatory pain and neuropathic pain. | Mol Pain. 2012 Apr 23;8:28. doi: 10.1186/1744-8069-8-28. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 22524543 | Likewise, in the spared nerve injury (SNI) model of neuropathic pain, hPAP (250 mU) inhibited thermal and mechanical hypersensitivity for three days in the ipsilateral (injured) hindpaw of wild-type mice but not A1Râ/â mice (Figure 4C,D). | Mol Pain. 2012 Apr 23;8:28. doi: 10.1186/1744-8069-8-28. | Neuropathic Pain | Mechanism |
| 22524543 | PAP has long-lasting, localized antinociceptive effects in chronic inflammatory and neuropathic pain models. | Mol Pain. 2012 Apr 23;8:28. doi: 10.1186/1744-8069-8-28. | Neuropathic Pain | Mechanism |
| 22524543 | Spared nerve injury (SNI) was used to model neuropathic pain. | Mol Pain. 2012 Apr 23;8:28. doi: 10.1186/1744-8069-8-28. | Neuropathic Pain | Mechanism |
| 38026466 | P-JNK promotes the induction of chemokine monocyte chemoattractant protein-1 (MCP-1) in astrocytes to contribute to the central sensitization of neuropathic pain (NP). | J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. | Neuropathic Pain | Mechanism |
| 38026466 | In summary, we conclude that IQAB alleviates neuropathic pain, improves the pathological changes and abnormal level of inflammatory cytokines in spinal cord. | J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. | Neuropathic Pain | Mechanism |
| 33398365 | Electroacupuncture (EA) has been used to treat neuropathic pain induced by peripheral nerve injury (PNI) by applying an electrical current to acupoints with acupuncture needles. | Mol Med Rep. 2021 Mar;23(3):175. doi: 10.3892/mmr.2020.11814. Epub 2021 Jan 5. | Neuropathic Pain | Mechanism |
| 33398365 | Electroacupuncture (EA) is used to treat neuropathic pain (NP) induced by peripheral nerve injury (PNI). | Mol Med Rep. 2021 Mar;23(3):175. doi: 10.3892/mmr.2020.11814. Epub 2021 Jan 5. | Neuropathic Pain | Mechanism |
| 30662282 | Gao et al found that the glycolysis/gluconeogenesis/hexose metabolism pathway might play an important role in supporting energy and neurotransmitter homeostasis following electroacupuncture treatment in rats with neuropathic pain. | J Pain Res. 2019 Jan 7;12:283-298. doi: 10.2147/JPR.S185916. eCollection 2019. | Neuropathic Pain | Mechanism |
| 30662282 | This hypothesis is supported by a recently published study that investigated the potential role of pyruvate kinase isozyme M2 (PKM2) in neuropathic pain, which demonstrated that inhibition of PKM2 expression effectively reduced neuropathic pain and inflammatory responses in a rat model by regulating the ERK) and STAT3 signaling pathways. | J Pain Res. 2019 Jan 7;12:283-298. doi: 10.2147/JPR.S185916. eCollection 2019. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 27978835 | Activation of hippocampal MEK1 contributes to the cumulative antinociceptive effect of electroacupuncture in neuropathic pain rats | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Neuropathic Pain | Mechanism |
| 27978835 | Therefore, the present study investigated the relationship between the effects of different numbers of EA intervention sessions and the activation of MEK1 in the hippocampus and hypothalamus in a rat model of neuropathic pain. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Neuropathic Pain | Mechanism |
| 27978835 | EA intervention can induce time-dependent cumulative analgesia in neuropathic pain rats after 4 successive sessions of daily EA intervention, which is at least in part related to the activation of hippocampal MEK1. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Neuropathic Pain | Mechanism |
| 27978835 | Neuropathic pain is a refractory chronic pain syndrome with a complicated mechanism that currently has no effective therapy. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Neuropathic Pain | Mechanism |
| 27978835 | Our previous study showed that the cumulative analgesic effect of repeated electroacupuncture (EA) intervention in neuropathic pain rats is closely associated with its regulatory effects on natural killer cells as well as some splenic and plasma cytokines. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect Neuropathic Pain | Mechanism |
| 27978835 | Our previous study demonstrated that in chronic constriction injury (CCI)-induced neuropathic pain rats, the cumulative analgesic effect of repeated EA stimulation of Zusanli (ST36)-Yanglingquan (GB34) is closely associated with its effects in upregulating the decreased hippocampal synaptophysin immunoreactivity and improving synaptic plasticity in the hippocampus. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect Immunity Neuropathic Pain | Mechanism |
| 27978835 | A close relationship has been documented between neuropathic pain and activation of MEK1. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Neuropathic Pain | Mechanism |
| 27978835 | In addition, we assessed the involvement of MEK1 in the cumulative analgesic effect of multiple sessions of EA intervention by intra-hippocampal injection of a MEK1 inhibitor in neuropathic pain rats. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect Neuropathic Pain | Mechanism |
| 27978835 | Effect of intra-hippocampal microinjection of the selective MEK1 inhibitor PD98059 at different time-points on PWL in a rat model of neuropathic pain. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Neuropathic Pain | Mechanism |
| 27978835 | Effect of the MEK1 inhibitor PD98059 on a hippocampal and b hypothalamic pMEK1 in a rat model of neuropathic pain. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Neuropathic Pain | Mechanism |
| 27978835 | Hence, these results suggest an apparent cumulative antinociceptive effect of four successive sessions of EA treatment in chronic neuropathic pain rats. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Neuropathic Pain | Mechanism |
| 27978835 | Because MEK1 signaling is necessary for cell survival, the reduction of MEK1 signaling observed in the hippocampus of chronic neuropathic pain animals may influence the reduction of neurogenic cells and decrease the hippocampal volume. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Neuropathic Pain | Mechanism |
| 27978835 | Our data showed that four successive sessions of daily EA treatment induced a time-dependent cumulative analgesic effect, which persists for at least 3Â days in a rat model of neuropathic pain. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect Neuropathic Pain | Mechanism |
| 30151295 | An in-vivo study reported that scolopendra pharmacopuncture alleviated neuropathic pain induced by L5 spinal nerve ligation in rats. | J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. | Neuropathic Pain | Mechanism |
| 30151295 | In the model of neuropathic pain, acupoint KI1, which is located in the metatarsal area, was selected; this differs from GV14, which is located in the cervical region and was used in our study. | J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. | Neuropathic Pain | Mechanism |
| 24803946 | Previous studies showed that acupuncture applied at both Shuigou (DU26) and Yanglingquan (GB34) acupoints simultaneously exerted a neuroprotection which would be partly mediated via inhibition of inflammation and microglial activation; furthermore, acupuncture alleviated neuropathic pain induced by SCI. | Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. | Neuroprotection Neuropathic Pain | Mechanism |
| 25206591 | In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect Neuropathic Pain Learning and Memory Ability | Mechanism |
| 25206591 | These findings indicate that repeated electroacupuncture at bilateral Zusanli and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25206591 | (1) Repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) relieved chronic neuropathic pain in a rat model of sciatic nerve injury. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Neuropathic Pain | Mechanism |
| 25206591 | Our previous studies demonstrated that in rats with sciatic nerve chronic constrictive injury (CCI), repeated EA intervention at Zusanli (ST36) and Yanglingquan (GB34) could effectively relieve neuropathic pain. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Neuropathic Pain | Mechanism |
| 25206591 | Results of the present study demonstrate that in chronic neuropathic pain and in OVX + CCI rats, the pain threshold is significantly decreased. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Neuropathic Pain | Mechanism |
| 25206591 | After EA intervention, the pain threshold was increased significantly in EA-2W rats, being markedly higher than in EA-2D rats, suggesting a cumulative analgesic effect of repeated EA stimulation of Zusanli and Yanglingquan in rats with neuropathic pain. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25206591 | For example, Yan et al observed that EA of Huantiao (GB30) and Weizhong (BL40) for one week clearly alleviates neuropathic pain in CCI rats. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Neuropathic Pain | Mechanism |
| 25206591 | In conclusion, repeated EA intervention of Zusanli and Yanglingquan has a cumulative analgesic effect in rats with chronic neuropathic pain. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25206591 | Chronic neuropathic pain model was established by ligation of the unilateral sciatic nerve according to a modification of previously published methods. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Neuropathic Pain | Mechanism |
| 25206545 | Molecular mechanisms underlying the effects of acupuncture on neuropathic pain | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | Acupuncture has been used to treat neuropathic pain for a long time, but its mechanisms of action remain unknown. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | In this study, we observed the effects of electroacupuncture and manual acu-puncture on neuropathic pain and on ephrin-B/EphB signaling in rats models of chronic constriction injury-induced neuropathic pain. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | The re-sults of this study suggest that acupuncture could activate ephrin-B/EphB signaling in neuropathic pain rats and improve neurological function. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | Chronic neuropathic pain not only refers to allodynia, but also the recovery of damaged nerves. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | However, few studies have addressed whether ephrin-Bs/EphBs are involved in the effects of acupuncture on neuropathic pain. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | This study investigated the expression of ephrin-Bs/EphBs in the spinal dorsal horn using rat models of neuropathic pain, and first verified that acupuncture for neuropathic pain and the recovery of neurological function are associated with the activation of ephrin-B/EphB signaling, indicating a potential mechanism of action for acupuncture in improving pain and repairing injured nerves. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | Peripheral nerve injury often leads to neuropathic pain, a chronic condition that can manifest behaviorally as spontaneous pain, hyperalgesia and allodynia, and which also results in neurological dysfunction. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | Management of neuropathic pain in patients still constitutes a remarkable therapeutic challenge owing to the modest and variable efficacy as well as the side effects of drugs. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain Side Effects | Mechanism |
| 25206545 | Therefore, investigations into effective therapies for the treatment of neuropathic pain, with fewer adverse effects, are highly relevant. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain Adverse Reactions | Mechanism |
| 25206545 | Acupuncture has been widely used to alleviate pain in human subjects and experimental animals with neuropathic pain, which mainly involves spinal opioid, adrenergic, dopaminergic, serotonergic, and cholinergic receptors. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | Manual acupuncture and electroacupuncture are frequently used in clinical practice, and both have shown therapeutic effects on neuropathic pain and functional improvement after neural injuries in pre-clinical and clinical studies. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | The present study aimed to explore whether neuropathic pain affects the expression of ephrin-Bs/EphBs in the spinal dorsal horn of chronic constriction injury rat models of neuropathic pain, and then examined whether manual acupuncture and electroacupuncture could interfere with the neuropathic pain by modulating ephrin-B/EphB expression. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | Nowadays, electroacupuncture and manual acupuncture treatments are extensively used to alleviate neuropathic pain and improve nervous function in the clinic. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | However, another study showed that there was no difference in alleviating headache, trigeminal neuralgia, and retro-auricular pain between electroacupuncture and manual acupuncture. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuralgia | Mechanism |
| 25206545 | However, previous studies have shown that acupuncture treatment modulates the expression and phosphorylation of spinal N-methyl-D-aspartate receptor subunits and inhibits p38MAPK and extracellular signal-regulated kinase activation in the spinal dorsal horn to attenuate mechanical allodynia in a neuropathic pain model. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 25206545 | Taken together, our findings provide new information that acupuncture increases the expression and synthesis of ephrin-B3 in the spinal dorsal horn, which subsequently promotes the restoration of injured neural function and finally results in neuropathic pain alleviation. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain | Mechanism |
| 37128191 | EA at GB34 reportedly increases BDNF expression in the SN of MPTP-treated mice, as well as in the spinal cord or neuropathic pain rat model, while MA at GB34 can enhance TrkB expression in the SN of a PD rat model. | J Tradit Complement Med. 2023 Jan 11;13(3):263-269. doi: 10.1016/j.jtcme.2023.01.005. eCollection 2023 May. | Neuropathic Pain | Mechanism |
| 37128191 | MA at GB34 can activate the ERK signaling pathway in the skin of a mouse pain model and the SN of an MPTP-induced PD mouse model, and EA at GB34 can activate ERK signaling in the hippocampus of neuropathic pain rats, as well as stressed rats. | J Tradit Complement Med. 2023 Jan 11;13(3):263-269. doi: 10.1016/j.jtcme.2023.01.005. eCollection 2023 May. | Neuropathic Pain | Mechanism |
| 31775332 | Electroacupuncture Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in Rats via Suppressing TLR4 Signaling and TRPV1 Upregulation in Sensory Neurons | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | Paclitaxel-induced peripheral neuropathy is a common adverse effect during paclitaxel treatment resulting in sensory abnormalities and neuropathic pain during chemotherapy and in cancer survivors. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain Adverse Reactions | Mechanism |
| 31775332 | Here, we examined the effects of electroacupuncture (EA) on a rat model of paclitaxel-induced neuropathic pain and related mechanisms. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | These results demonstrated that EA alleviates paclitaxel-induced peripheral neuropathic pain via mechanisms possibly involving suppressing TLR4 signaling and TRPV1 upregulation in DRG neurons, which further result in reduced spinal glia activation. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | Our work supports EA as a potential alternative therapy for paclitaxel-induced neuropathic pain. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | The peripheral neuropathy causes neuropathic pain symptoms, which are characterized with burning pain, tingling, numbness, and allodynia in the hands and feet of patients. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | TRPV1 expression is upregulated in dorsal root ganglion (DRG) neurons of rats treated with paclitaxel, whereas TRPV1 antagonists significantly reduced pain hypersensitivities, suggesting that TRPV1 makes major contributions to paclitaxel-induced neuropathic pain symptoms. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | Pharmacological blocking or genetic deletion of TLR4 or MyD88 attenuates paclitaxel-induced neuropathic pain. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | TRPV1 expression and activity in DRG neurons can be enhanced by TLR4 in chronic inflammation and paclitaxel-induced neuropathic pain conditions. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | Therefore, paclitaxel may engage with TLR4 and its downstream signaling to promote the expression and activity of TRPV1 channel in peripheral sensory neurons, resulting in augmented nociceptive signals that contribute to neuropathic pain. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | It has demonstrated that EA can ameliorate neuropathic pain conditions of paclitaxel-treated rats. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | Therefore, in the present study, we aim to explore whether EA may alleviate paclitaxel-induced neuropathic pain via suppressing TLR4 signaling and TRPV1 upregulation in DRG neurons. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | EA Significantly Alleviated both Thermal and Mechanical Hypersensitivities in a Rat Model of Paclitaxel-Induced Peripheral Neuropathic Pain | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | We first established the rat model of paclitaxel-induced peripheral neuropathic pain via multiple paclitaxel injections according to protocols reported before (Figure 1A). | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | These results were consistent with previous reports, indicating the successful establishment of paclitaxel-induced peripheral neuropathic pain in rats. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | It is well established that TRPV1 channel expression is increased in DRGs upon paclitaxel treatment and plays a critical role in mediating paclitaxel-induced peripheral neuropathic pain. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | TLR4 and its downstream signaling molecule MyD88 are both increased in DRGs of paclitaxel-treated rats and are involved in paclitaxel-induced peripheral neuropathic pain. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | Astrocytes and microglia are activated in SCDH of paclitaxel-induced peripheral neuropathic pain animals and are involved in pain mechanisms. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | These data demonstrated that paclitaxel-induced peripheral neuropathic pain is accompanied with significant astrocyte and microglia activation in SCDH and that EA effectively attenuates astrocyte and microglia activation in SCDH of paclitaxel-treated rats. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | In the present study, we established a rat model of paclitaxel-induced peripheral neuropathic pain and evaluated the therapeutic effects of EA on the pain hypersensitivities of paclitaxel-treated rats. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | These results suggest that EA alleviates paclitaxel-induced peripheral neuropathic pain via mechanisms possibly involving suppressing TLR4 signaling and TRPV1 channel upregulation in DRGs and spinal glial cell activation. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | The link between TLR4 and TRPV1 in pain conditions, including paclitaxel-induced peripheral neuropathic pain, has been well documented. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | More importantly, TRPV1 expression or channel activity in DRG neurons can be significantly enhanced by TLR4 under inflammation or paclitaxel-induced neuropathic pain conditions. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | These studies all suggested that TLR4 can enhance TRPV1 expression and channel activity in DRG neurons during paclitaxel-induced peripheral neuropathic pain. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | It is reported that paclitaxel-induced peripheral neuropathic pain is accompanied with astrocyte and microglia activation in SCDH. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | Pharmacological blocking of astrocytes or microglia attenuated paclitaxel-induced neuropathic pain, suggesting spinal glial cells contributed to pain mechanisms of paclitaxel-induced neuropathic pain. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | This result suggests that EA may alleviate paclitaxel-induced neuropathic pain via suppressing astrocyte and microglia activation in SCDH. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | Our study demonstrates that EA treatment ameliorates pain hypersensitivities in a rat model of paclitaxel-induced neuropathic pain. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | Our work supports EA as a potential therapeutic option for paclitaxel-induced neuropathic pain in clinic. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | Electroacupuncture (EA) attenuates both mechanical allodynia and thermal hyperalgesia in a rat model of paclitaxel-induced peripheral neuropathic pain. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 31775332 | (A) Experimental protocol for the establishment of the rat model of paclitaxel-induced peripheral neuropathic pain and EA/sham EA treatment. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Neuropathic Pain | Mechanism |
| 28600329 | Loss of GABAB receptors on primary afferent neurons may lead to mechanical allodynia, while application of GABA agonists to the DRG attenuates pain behaviour in rats with neuropathic pain. | Acupunct Med. 2017 Aug;35(4):276-283. doi: 10.1136/acupmed-2016-011177. Epub 2017 Jun 9. | Neuropathic Pain | Mechanism |
| 28600329 | After application of selective GABAA (but not GABAB) receptor agonists, an analgesic effect is seen in rat models of inflammatory and neuropathic pain. | Acupunct Med. 2017 Aug;35(4):276-283. doi: 10.1136/acupmed-2016-011177. Epub 2017 Jun 9. | Analgesic Effect Neuropathic Pain | Mechanism |
| 29033603 | Electroacupuncture (EA) was performed at GB30 to study the analgesic effects on neuropathic pain and the underlying mechanisms. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Analgesic Effect Neuropathic Pain | Mechanism |
| 29033603 | The CCIp model is better than the CCI model for studying acupuncture analgesia on chronic neuropathic pain and the underlying mechanisms. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | Sciatica, one of the most common sources of clinical neuropathic pain, is generally defined as pain radiating to the leg, normally below the knee and into the foot and toes. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | Therefore, generating appropriate animal models are critical to developing novel treatment options for neuropathic pain. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | Chronic constriction injury of the sciatic nerve (CCI) was established in 1988 as a means to produce neuropathic pain in laboratory animal models; the pathological condition of this model is quite similar to human peripheral nerve injury and its consequent behavioral manifestations. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | This suggests the need for a proper animal model in order to elucidate mechanisms by which acupuncture alleviates neuropathic pain. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | These data suggest that ligation of either the trunk or the two branches of the sciatic nerve is capable of inducing hyperalgesia and producing neuropathic pain in the affected hind limb in rats; the phenotypes of CCIp are similar to those of CCI. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | In the present study, we found that ligation of the common peroneal and tibial branches of the sciatic nerve in rats was capable of inducing phenotypes of neuropathic pain and significantly decreasing PMWL and PMWT, similar to ligation of the sciatic nerve trunk. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | To investigate underlying mechanisms of neuropathic pain, the CCI model was established. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | To date, CCI is still the most common research model used to study neuropathic pain in animals. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | Therefore, the CCI model is best utilized to mimic the symptoms and behaviors of chronic neuropathic pain in human peripheral nerve injuries (tumor suppression, heavy metal poisoning, hypoxia, or metabolic abnormalities). | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | Our pain behavior data showed that both CCI and CCIp modeling could mimic neuropathic pain. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | Our behavior and immunohistochemistry data suggest that the CCIp model may be as good as the CCI model for studying the effects and mechanisms of acupuncture analgesia on chronic neuropathic pain in experimental animals. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Immunity Neuropathic Pain | Mechanism |
| 29033603 | CCIp model was preferential to CCI model because C-fiber reflex EMG can be induced in this model to further evaluate neuropathic pain and acupuncture analgesia effects in vivo in electrophysiological studies. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | The finding that EA at GB30 could increase pain threshold as well as inhibit nociceptive reflex EMG in CCIp rats provides solid evidence that the CCIp model could be used to study acupuncture analgesia on neuropathic pain as well as its underlying mechanisms. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 29033603 | But C-fiber reflex EMG, which is an objective and direct criterion in evaluation of pain and acupuncture analgesia, could only be induced in CCIp model, indicating CCIp model is preferential to the CCI model for experimentally studying acupuncture analgesia on chronic neuropathic pain and its responsible mechanisms. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Neuropathic Pain | Mechanism |
| 37143500 | Analgesic effects and metabolome analyses of laser- and electro-acupuncture combined therapies in paclitaxel-induced neuropathic pain model | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Analgesic Effect Neuropathic Pain | Mechanism |
| 37143500 | Neuropathic pain, which is spontaneous and persistent, often requires adjuvant treatment, such as combined analgesic administration or other interventional pain treatments. | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Neuropathic Pain | Mechanism |
| 24757373 | observed that electroacupuncture at ST36 and SP9 relieves neuropathic pain in rats. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Neuropathic Pain | Mechanism |
| 30510442 | Moreover, other studies also found that activated peripheral CB2 receptor reduces inflammatory pain and neuropathic pain. | J Pain Res. 2018 Nov 8;11:2797-2808. doi: 10.2147/JPR.S171664. eCollection 2018. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 30510442 | In addition, previous studies showed that the activated peripheral CB2 receptor can reduce inflammatory pain and neuropathic pain. | J Pain Res. 2018 Nov 8;11:2797-2808. doi: 10.2147/JPR.S171664. eCollection 2018. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 35416841 | Analgesia with 5' extracellular nucleotidase-mediated electroacupuncture for neuropathic pain | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Neuropathic Pain | Mechanism |
| 35416841 | Acupuncture is a treatment for neuropathic pain, but its mechanism remains unclear. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Neuropathic Pain | Mechanism |
| 35416841 | Previous studies showed that analgesia was induced in rats with neuropathic pain when their spinal cord adenosine content increased after electroacupuncture (EA); however, the mechanism behind this electroacupuncture-induced increase has not been clarified. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Neuropathic Pain | Mechanism |
| 35416841 | We performed electroacupuncture at the Zusanli acupoint on the seventh day after establishing a rat model of neuropathic pain induced through chronic constriction injuries. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Neuropathic Pain | Mechanism |
| 35416841 | Neuropathic pain has a high incidence rate and its treatment is difficult. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Neuropathic Pain | Mechanism |
| 31485183 | Through investigation of its effects on neuralgia, found that laser needle-knife was an effective method of relieving hyperalgia and paralgesia. | Saudi J Biol Sci. 2019 Feb;26(2):390-394. doi: 10.1016/j.sjbs.2018.11.011. Epub 2018 Nov 20. | Neuralgia | Mechanism |
| 28860844 | Cognitive effects of electro-acupuncture and pregabalin in a trigeminal neuralgia rat model induced by cobra venom | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | The objective of this study was to investigate the effects of electro-acupuncture (EA) and pregabalin on cognition impairment induced by chronic trigeminal neuralgia (TN) in rats. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | Cognitive dysfunction is a common complication of chronic neuropathic pain, which involves changes in both nerve electrophysiology and anatomy of the brain. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain Cognitive Function | Mechanism |
| 28860844 | Our previous study revealed that chronic trigeminal neuralgia in rats induced by cobra venom impairs spatial learning and memory function as assessed by the Morris water maze test. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia Learning and Memory Ability | Mechanism |
| 28860844 | All these studies suggest that EA may be a cost-effective alternative in relieving neuropathic pain and improving cognitive function. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain Cognitive Function | Mechanism |
| 28860844 | Previous studies have indicated that pregabalin appears to be effective in the treatment of trigeminal neuralgia. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | In this study, we used behavioral testing to confirm the analgesic effects of EA and pregabalin in a rat model of trigeminal neuralgia induced by cobra venom. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Analgesic Effect Neuralgia | Mechanism |
| 28860844 | In addition, we discuss the possible mechanisms of EA and pregabalin in improving cognitive impairment induced by chronic trigeminal neuralgia in rats. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | Trigeminal neuralgia model establishment | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | Also, in 30 rats, 4 µL cobra venom (mixture of 0.4 mg lyophilized cobra venom; Venom Research Institute of Guangxi Medical University) was injected into the infraorbital nerve on the left side to establish a rat model of trigeminal neuralgia (10 rats) and two treatment groups, EA and pregabalin (10 rats in each group). | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | Behavioral changes of trigeminal neuralgia model | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | EA and pregabalin are widely used clinically to treat trigeminal neuralgia. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | However, for understanding the analgesic and cognitive effects of EA and pregabalin on ameliorating chronic trigeminal neuralgia better, a simple and reliable animal model is required. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | Previously, our team established a trigeminal neuralgia model induced by cobra venom, which demonstrated reproducible changes in exploratory and grooming behavior. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | In this study, we applied our model to experimentally reproduce trigeminal neuralgia. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | In view of the above results, we believe that we successfully demonstrated a reproducible rat model of trigeminal neuralgia. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | The results of this study are consistent with these previous findings, indicating similar analgesic effects of EA stimulation and pregabalin in treating trigeminal neuralgia. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Analgesic Effect Neuralgia | Mechanism |
| 28860844 | We further confirmed a definite analgesic behavioral effect secondary to EA stimulation and pregabalin in trigeminal neuralgia. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | This suggests that inhibition of nerve demyelination might be the major mechanism of EA and pregabalin in alleviating the chronic trigeminal neuralgia induced by cobra venom. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | Cognitive effects of EA and pregabalin in a trigeminal neuralgia rat model induced by cobra venom | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | Wu et al revealed that chronic trigeminal neuralgia induced by cobra venom in rats impairs spatial learning and memory function in the Morris water maze test. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia Learning and Memory Ability | Mechanism |
| 28860844 | These findings indicated that trigeminal neuralgia induced by cobra venom in rats could lead to deficits in areas of the brain associated with the abilities of spatial learning and memory. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia Learning and Memory Ability | Mechanism |
| 28860844 | These findings suggest that EA stimulation may improve the cognitive dysfunction of rats associated with cobra venom-induced trigeminal neuropathic pain, whereas pregabalin does not. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain Cognitive Function | Mechanism |
| 28860844 | Both peripheral and central mechanisms are critical in understanding and treating neuropathic pain. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain | Mechanism |
| 28860844 | Also, our results are dependent on our own experimental model producing changes such as trigeminal neuralgia in a clinical setting. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia | Mechanism |
| 28860844 | Nonetheless, the relationship between trigeminal neuralgia, cognitive dysfunction and treatment options requires further study. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia Cognitive Function | Mechanism |
| 28860844 | In brief, these data indicate that EA stimulation not only decreased neuropathic pain behavior induced by cobra venom, but also improved deficits in spatial learning and memory abilities induced by chronic trigeminal neuralgia. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain Neuralgia Learning and Memory Ability | Mechanism |
| 28860844 | However, pregabalin only ameliorated the trigeminal neuropathic pain behavior induced by cobra venom without affecting the cognitive dysfunction induced by this experimental model. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain Cognitive Function | Mechanism |
| 25767502 | Acupuncture effects on the hippocampal cholinergic system in a rat model of neuropathic painâ | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Neuropathic Pain | Mechanism |
| 25767502 | The present study observed the effects of repeated electroacupuncture of Zusanli (ST36) and Yanglingquan (GB34) on expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA in chronic constrictive injury (neuropathic pain) and/or ovariotomy rats. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Neuropathic Pain | Mechanism |
| 25767502 | Results demonstrated increased expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA, as well as decreased pain threshold, in a rat model of chronic neuropathic pain after electroacupuncture. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Neuropathic Pain | Mechanism |
| 25767502 | Models of chronic neuropathic pain were established in CCI, CCI + EA 2D, CCI + EA 2W, CCI + OVX, CCI + OVX + EA 2D, and CCI + OVX + EA 2W groups. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Neuropathic Pain | Mechanism |
| 25767502 | Models of OVX-induced learning-memory attenuation were generated in the CCI + OVX, CCI + OVX + EA 2D, and CCI + OVX + EA 2W groups before model establishment of chronic neuropathic pain. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Neuropathic Pain Learning and Memory Ability | Mechanism |
| 25767502 | These results suggested that increased ACh synthesis was likely due to autonomic self-protection during chronic neuropathic pain stress stimulation. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Neuropathic Pain | Mechanism |
| 25767502 | Establishment of chronic neuropathic pain model (CCI) | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Neuropathic Pain | Mechanism |
| 25657670 | In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25657670 | Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25657670 | Our previous studies demonstrated that, in chronic constrictive injury (CCI) of the sciatic nerve in rats, repeated electroacupuncture intervention effectively relieved neuropathic pain. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Neuropathic Pain | Mechanism |
| 25657670 | The CCI model of chronic neuropathic pain was employed in the CCI, CCI + electroacupuncture 2 days, CCI + electroacupuncture 2 weeks, CCI + OVX, CCI + OVX + electroacupuncture 2 days and the CCI + OVX + electroacupuncture 2 weeks groups. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Neuropathic Pain | Mechanism |
| 25657670 | The OVX model of learning and memory impairment was applied in the CCI + OVX, CCI + OVX + electroacupuncture 2 days and the CCI + OVX + electroacupuncture 2 weeks groups before establishment of chronic neuropathic pain. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Neuropathic Pain Learning and Memory Ability | Mechanism |
| 25657670 | Our present results revealed that, in chronic neuropathic pain rats, the pain threshold was decreased significantly. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Neuropathic Pain | Mechanism |
| 25657670 | This outcome is similar to previous results that electroacupuncture at Huantiao (GB30) and Weizhong (BL40) for one week alleviates neuropathic pain in CCI rats. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Neuropathic Pain | Mechanism |
| 25657670 | Xing et al found that, in rats with neuropathic pain, electroacupuncture treatment had a modulatory effect on long-term synaptic plasticity in the spinal dorsal horn. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Neuropathic Pain | Mechanism |
| 25657670 | In conclusion, repeated electroacupuncture at Zusanli and Yanglingquan has a cumulative analgesic effect on chronic neuropathic pain in rats. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25657670 | A model of chronic neuropathic pain was established by ligation of the sciatic nerve, based on a modification of the Bennett and Xie method. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Neuropathic Pain | Mechanism |
| 23573158 | Many experimental models of pathological pain, including inflammatory pain, neuropathic pain, and bone cancer pain, show a significant regional elevation of dynorphin and κ receptor in the spinal cord. | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Neuropathic Pain Cancer Pain Inflammatory Pain | Mechanism |
| 32967614 | Acupuncture attenuates the development of diabetic peripheral neuralgia by regulating P2X4 expression and inflammation in rat spinal microglia | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Neuralgia | Mechanism |
| 32967614 | Other evidences also showed that activating the functions of P2X4Rs of spinal microglia have important pathophysiological roles in evoking neuropathic pain. | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Neuropathic Pain | Mechanism |
| 32967614 | On the premise that blood glucose remains stable, and there is a statistical difference between mechanical pain and heat pain, it is considered to be a model of diabetic peripheral neuralgia (DPN). | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Neuralgia | Mechanism |
| 32967614 | The neuralgia of rats appeared about 2Â weeks after the model was manufactured. | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Neuralgia | Mechanism |
| 32967614 | Thereby confirms establishing a model of DPN that exhibits neuropathic pain-related indicators. | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Neuropathic Pain | Mechanism |
| 32967614 | In order to validate the model of type II diabetes that exhibits neuropathic pain, we performed additional studies to find its stabilization time. | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Neuropathic Pain | Mechanism |
| 32967614 | This demonstrates the accuracy and stability of the novel rat model of type II diabetic neuropathic pain that we developed in this study. | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Neuropathic Pain | Mechanism |
| 32967614 | A previous report showed that P2X4 receptors of activated microglia in the spinal cord are involved in the pathogenesis of neuropathic pain, and reported that P2X4 receptors expression was increased by spinal microglia during neuropathic pain. | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Neuropathic Pain | Mechanism |
| 32042305 | Cancer-induced bone pain (CIBP) presents a multiple-mechanism of chronic pain involving both inflammatory and neuropathic pain, and its pathogenesis is closely related to endogenous descending system of pain control. | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Neuropathic Pain | Mechanism |
| 32042305 | CIBP presents a multiple-mechanism of chronic pain involving both inflammatory and neuropathic pain, and often occurs at more than one site due to tumor expansion, causing damage to the primary afferent nerve fibers of bone and releasing various inflammatory mediators. | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Neuropathic Pain | Mechanism |
| 32042305 | On day 15, ipsilateral 50% PWT increased sharply in EA group, since electroacupuncture of 2/100Â Hz can inhibit hyperalgesia and hypersensitivity caused by neuropathic pain, and stimulate the cumulative effect of multiple stimuli. | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Neuropathic Pain | Mechanism |
| 32042305 | RVM neurons of the descending pain inhibition system expressing MOR contribute to the maintenance and perception of neuropathic pain. | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Neuropathic Pain | Mechanism |
| 27411565 | Researchers have conducted clinical trials and animal model studies on neuropathic pain and collagen-induced arthritis and demonstrated the descending modulation of nociceptive processing. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Neuropathic Pain | Mechanism |
| 27411565 | suggested that ondansetron could have an analgesic effect in neuropathic pain in a double-blind study and Ali Z et al. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect Neuropathic Pain | Mechanism |
| 20953422 | Some of the common applications of acupuncture include heart disease, smoking cessation, and the treatment of inflammatory diseases such as rheumatoid arthritis (RA), autonomic dysfunction, neurological diseases, neuropathic pains, drug addiction, and psychological disorders. | Evid Based Complement Alternat Med. 2011;2011:290489. doi: 10.1155/2011/290489. Epub 2010 Sep 14. | Neuropathic Pain | Mechanism |
| 22110373 | Additionally, we studied p35 expression when electroacupuncture (EA) and a sub-effective dose of NMDA (N-methyl-D-aspartate) receptor antagonist (MK-801) were used to treat hyperalgesia in the diabetic neuropathic pain (DNP). | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | Additionally, EA combined with MK-801 prolonged anti-hyperalgesia, increased p35 expression, and decreased the cleavage of p35 to p25 during diabetic neuropathic pain. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | Diabetic neuropathic pain and NMDA | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | Diabetic neuropathic pain remains an unmet clinical problem and is poorly relieved by conventional analgesics. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | Although N-methyl-d-aspartate (NMDA) receptors antagonists are highly effective in reducing neuropathic pain, these agents cause severe side effects at therapeutic doses, which limit their clinical uses. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain Side Effects | Mechanism |
| 22110373 | Diabetic neuropathic pain and p35 | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | Moreover, we tested the hypothesis that synergic treatment with an NMDA antagonist along with electroacupuncture produces analgesic effects greater than either agent alone in a maintained diabetic neuropathic pain phase, and we identified alterations in p35 level in response to analgesic effects. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Analgesic Effect Neuropathic Pain | Mechanism |
| 22110373 | Diabetic neuropathic pain model | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | Some articles have shown hypoalgesia to heat stimulation in the early phase (1~2 weeks after streptozotocin) of streptozotocin-induced diabetic neuropathic pain. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | This model follows some of the criteria that define neuropathic pain: hyperalgesia to thermal and mechanical noxious stimuli. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | Diabetic neuropathic pain and acupuncture | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | Acupuncture therapies have become increasingly popular and are prescribed commonly by patients with chronic neurological disorders, including diabetic neuropathic pain. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | NMDA receptors are involved in persistent pain and play an important role in central sensitization in diabetic neuropathic pain. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | Although NMDA antagonists are highly effective in reducing neuropathic pain, these agents cause side effects at therapeutic doses including hallucination, dysphoria, and impairment of cognitive function. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain Cognitive Function Side Effects | Mechanism |
| 22110373 | Additionally, a combination of NMDA receptor antagonists with opioids has been shown to be efficient in the treatment of diabetic neuropathic pain and other forms of neuropathic pain. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | In this study, EA stimulation was applied at acupoint SP9 or ST36 in the diabetic neuropathic pain. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | demonstrated that MK-801 blocked the 2-Hz EA-induced spinal long-term depression of C-fiber-evoked potentials in spinal nerve ligation-induced neuropathic pain model. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain Depression | Mechanism |
| 22110373 | Our findings suggest that p35 will be a good target molecule for explaining the mechanism of complicated algesia in diabetic neuropathic pain. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 22110373 | Spinal p35/p25 involvement in STZ-induced diabetic neuropathic pain rats. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain | Mechanism |
| 21799685 | administration of m-5-HT, a 5-HT2A/2C receptor agonist, dosage-dependently suppressed the number of flinches in the formalin test and attenuated thermal hyperalgesia in a rat model of neuropathic pain. | Evid Based Complement Alternat Med. 2011;2011:619650. doi: 10.1093/ecam/neq016. Epub 2011 Jan 9. | Neuropathic Pain | Mechanism |
| 21799685 | In contrast to our study, a previous study demonstrates that spinal 5-HT1A and 5-HT3 receptor antagonists, but not the HT2A/2C receptor antagonist ketanserin, blocked EA-produced inhibition of cold allodynia in a rat model of neuropathic pain. | Evid Based Complement Alternat Med. 2011;2011:619650. doi: 10.1093/ecam/neq016. Epub 2011 Jan 9. | Neuropathic Pain | Mechanism |
| 27381504 | For example, Wu and Zhou reported that NR2B-containing NMDARs are potential targets for treatment of neuropathic pain. | Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. | Neuropathic Pain | Mechanism |
| 27381504 | Xing et al found high baseline field potential amplitudes and a lower C-fibre LTP threshold in the SC dorsal horn of a rat neuropathic pain model. | Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. | Neuropathic Pain | Mechanism |
| 26770252 | Persistent neuropathic pain is associated with anxiety. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain Anxiety | Mechanism |
| 26770252 | In last decades, preclinical and clinical researches have demonstrated that MA and EA are, respectively, effective for neuropathic pain and anxiety; however, it is unknown whether they have an effective role for neuropathic pain-induced negative mood. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain Anxiety Mood | Mechanism |
| 26770252 | Accumulating evidence has shown that extracellular signal-regulated kinase (ERK), a family member of mitogen-activated protein kinases (MAPKs), in the ACC is activated in the chemical inflammatory pain or neuropathic pain model and suggested that pain-induced anxiety is regulated by the ERK activation in the ACC after incision. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain Anxiety Inflammatory Pain | Mechanism |
| 26770252 | Surgery for Neuropathic Pain Model | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain | Mechanism |
| 26770252 | The present study is the first to show that both sMA and EA stimulation significantly relieve mechanical hypersensitivity in a rat model of neuropathic pain, and both sMA and mMA stimulation significantly reduce anxiety-like behavior. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain Anxiety | Mechanism |
| 26770252 | Hence, sMA might be the treatment of choice in cases of neuropathic pain accompanied by anxiety. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain Anxiety | Mechanism |
| 26770252 | The L5 spinal nerve ligation-induced neuropathic pain is similar to the low back pain in clinical. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain | Mechanism |
| 26770252 | Therefore, in this study we select GB 30 (main point) and GB 34 (additional point) to alleviate SNL-induced neuropathic pain. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain | Mechanism |
| 26770252 | In the present study, we observed that the sensory dimension of neuropathic pain, measured by PWTs, decreased consistently from day 3 after surgery. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain | Mechanism |
| 26770252 | In summary, sMA stimulation may relieve both mechanical hyperalgesia and pain-induced anxiety in a rat model of neuropathic pain, while mMA only reduces anxiety and EA only alleviates mechanical hypersensitivity. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain Anxiety | Mechanism |
| 26064176 | Acupuncture originated in ancient China has been proved to have a promising analgesic effect on several pain disorders, such as neuropathic pain, inflammatory pain, and cancer pain. | Evid Based Complement Alternat Med. 2015;2015:848603. doi: 10.1155/2015/848603. Epub 2015 Apr 29. | Analgesic Effect Neuropathic Pain Cancer Pain Inflammatory Pain | Mechanism |
| 26064176 | EA treatment also inhibited the activation of microglial p38 mitogen-activated protein kinase (p38MAPK) and extracellular signal-regulated kinase (ERK) signaling and attenuated the neuropathic pain caused by spinal cord injury. | Evid Based Complement Alternat Med. 2015;2015:848603. doi: 10.1155/2015/848603. Epub 2015 Apr 29. | Neuropathic Pain | Mechanism |
| 26064176 | Previous work has shown that the level of GRK2 was significantly decreased in chronic neuropathic pain and inflammatory pain. | Evid Based Complement Alternat Med. 2015;2015:848603. doi: 10.1155/2015/848603. Epub 2015 Apr 29. | Neuropathic Pain Inflammatory Pain | Mechanism |
| 36277498 | Electroacupuncture alleviates orofacial allodynia and anxiety-like behaviors by regulating synaptic plasticity of the CA1 hippocampal region in a mouse model of trigeminal neuralgia | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Neuralgia Anxiety | Mechanism |
| 36277498 | Trigeminal neuralgia (TN), one of the most severe and debilitating chronic pain conditions, is often accompanied by mood disorders, such as anxiety and depression. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Neuralgia Anxiety Depression Mood | Mechanism |
| 36277498 | A mouse infraorbital nerve transection model (pT-ION) of neuropathic pain was established, and EA or sham EA was used to treat ipsilateral acupuncture points (GV20-Baihui and ST7-Xiaguan). | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Neuropathic Pain | Mechanism |
| 36277498 | According to the International Headache Society and the third edition of the International Classification of Headache Disorders, trigeminal neuralgia (TN) is characterized by recurrent unilateral brief electric shock-like pains. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Neuralgia | Mechanism |
| 36277498 | TN is a chronic neuropathic pain which often causes mood disorders, such as anxiety and depression. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Neuropathic Pain Anxiety Depression Mood | Mechanism |
| 36277498 | Some previous studies demonstrated that EA attenuates neuropathic pain and depression by improving the synaptic plasticity of spinal cord and hippocampus. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Neuropathic Pain Depression | Mechanism |
| 36277498 | Pathological changes in synapses are frequently seen in neuropathic pain and depression, including an abnormal synaptic density, reduced PSD and associated proteins, shortened active zone length, decreased curvature of the synaptic interface, and widened synaptic cleft. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Neuropathic Pain Depression | Mechanism |
| 36277498 | This study demonstrates that EA has significant analgesic and anxiolytic effects on pT-ION-induced neuropathic pain and related anxiety-like behaviors. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Neuropathic Pain Anxiety | Mechanism |
| 25368638 | In neuropathic pain, there is upregulation of P2X purinoceptor 3 (P2X3) receptor expression in dorsal root ganglion neurons. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Neuropathic Pain | Mechanism |
| 25368638 | Electroacupuncture may act via purinergic A1 and P2X3 receptors simultaneously to induce an analgesic effect on neuropathic pain. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25368638 | Electroacupuncture may induce an analgesic effect in neuropathic pain by influencing both purinergic A1 and P2X purinoceptor 3 (P2X3) receptors simultaneously. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25368638 | Electroacupuncture can inhibit purinergic A1 and P2X3 receptors and exert an analgesic effect on neuropathic pain. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25368638 | In the model of neuropathic pain described above, ATP is released from damaged peripheral nerve tissue and plays an important role in the initiation of pain by sensitizing primary afferents. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Neuropathic Pain | Mechanism |
| 25368638 | Neuropathic pain results in upregulation of P2X3 receptor expression on dorsal root ganglion neurons and causes primary sensory neurons to become hyperexcitable to ATP-evoked inward currents. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Neuropathic Pain | Mechanism |
| 25368638 | This suggests that P2X3 receptors are critical in the development of neuropathic pain and that electroacupuncture treatment could likely cause analgesia by decreasing expression and sensitization of P2X3 receptors. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Neuropathic Pain | Mechanism |
| 25368638 | Electroacupuncture treatment produces a long-lasting analgesic effect on neuropathic pain and increases expression of P2X3 receptors in the midbrain periaqueductal gray matter, which potentiates the function of the purinergic signaling system at the supraspinal level and provides a rational basis for explaining the analgesic effect of electroacupuncture. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25368638 | In summary, the analgesic role of electroacupuncture in neuropathic pain may involve purinergic A1 and P2X3 receptors simultaneously. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Neuropathic Pain | Mechanism |
| 25368638 | Neuropathic pain typically occurs after nerve damage that can be induced by physical injury, nerve compression by tumors or intervertebral discs, diabetes, infection or autoimmune disease. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Neuropathic Pain | Mechanism |
| 25368638 | Evidence accumulated from neuropathic pain models suggests that neuropathic pain might involve abnormal excitability of the nervous system. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Neuropathic Pain | Mechanism |
| 25368638 | In neuropathic pain model, changes in the expression levels of A1 and P2X3 receptors can be observed before and after electroacupuncture treatment, an observation that can be used as a paradigm to explore the importance of the balance between each receptor system in the peripheral and central nervous systems. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Neuropathic Pain | Mechanism |
| 25368638 | For example, rats with deleted A1 receptors can be used to evaluate whether electroacupuncture treatment alters mechanical and thermal pain thresholds, and the influence of selective A1 and P2X3 receptor antagonists can be explored in rat models of neuropathic pain. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Neuropathic Pain | Mechanism |
| 25368638 | In patients with chronic neuropathic pain, adenosine compounds appear to mediate their analgesic effects through A1 receptor-related modulation of central sensitization at spinal or supraspinal levels. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25368638 | It has been suggested that in neuropathic pain there are disturbances in the endogenous adenosine system that lead to a deficiency of adenosine in the blood and cerebrospinal fluid, which may explain the potential therapeutic anti-neuropathic effects of adenosine or its analogs. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Neuropathic Pain | Mechanism |
| 29946236 | EA has been shown to reduce neuroinflammation in animal models of neuropathic pain (Li et al.,). | Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. | Neuropathic Pain | Mechanism |